DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hlc and CG9253

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_610090.1	Gene:	CG9253 / 35379	FlyBaseID:	FBgn0032919	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	131/462 - (28%)
Similarity:	223/462 - (48%)	Gaps:	71/462 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QKTVQFHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQK 70
            ::.:.:.:|.|::.:.:|..:|.|:.|:.||..|||:.|:||||:..|.||||||..:|||::..
  Fly    58 EQKLTWKDLGLNEALCQACDELKWKAPSKIQREAIPVALQGKDVIGLAETGSGKTGAFALPILHA 122

  Fly    71 ILNSKLNASEQYVSAVVLAPTKELCRQSRKVIEQL-----VESCGKVVRVADIADSSNDTVTQRH 130
            :|.     :.|...|:||.||:||..|..:..|.|     ::.|        :.....|.|.|..
  Fly   123 LLE-----NPQRYFALVLTPTRELAFQIGEQFEALGSGIGIKCC--------VVVGGMDMVAQGL 174

  Fly   131 ALSESPDIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHLPPIYQAV 195
            .|::.|.|::|||..|:.:.|.....:||.::.||:||||.:....:|.:..:::|.||...:..
  Fly   175 QLAKKPHIIIATPGRLVDHLENMKGFNLKAIKYLVMDEADRILNMDFEVELDKILKVLPRERRTF 239

  Fly   196 LVSATLTDDVVRMKGLCLNNPVTLKLEEP-ELVPQDQLSHQRILAEENDKPAILYALLKLRLIRG 259
            |.|||:|..|.:::...|.:||.:::... :.|.|.|.|:..|..:..|    :|.:..|..:.|
  Fly   240 LFSATMTKKVKKLQRASLKDPVKVEVSNKYQTVEQLQQSYLFIPVKYKD----VYLVHILNELAG 300

  Fly   260 KS-IIFVNSIDRCYKVRLFLEQFGIRACVLNSELPANIRIHTISQFNKGTYDIIIASDEHHMEKP 323
            .| :||.::.:...|..|.|...|:.|..|:.::..|.|:..:::|......|:|::|
  Fly   301 NSFMIFCSTCNNTVKTALMLRALGLAAIPLHGQMSQNKRLAALNKFKAKNRSILISTD------- 358

  Fly   324 GGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARGNNKGSVLSFVS 388
                              .||||:|...|:.|:|||.|.....||||.|||||....|..::.||
  Fly   359 ------------------VASRGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRSGKAITLVS 405

  Fly   389 MKESKVNDSVEKKLCDSFAAQEGEQIIKNYQFKMEEVESFRYRAQDCWRAATRVAVHDTRIREIK 453
            ..:.::...:|..|        |:|:.. |:.:.:||.:.:.|..:..|.|             |
  Fly   406 QYDIELYQRIEHLL--------GKQLTL-YKCEEDEVMALQERVAEAQRTA-------------K 448

  Fly   454 IEILNCE 460
            :|:.:.|
  Fly   449 LELKDLE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	71/213 (33%)
		DEXDc	24..231	CDD:214692	70/212 (33%)
		HELICc	234..386	CDD:238034	41/152 (27%)
CG9253	NP_610090.1	SrmB	34..498	CDD:223587	131/462 (28%)
		DEADc	63..264	CDD:238167	71/213 (33%)
		HELICc	274..403	CDD:238034	44/157 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940