Protein Alignment Hlc and DDX51

DIOPT Version :9

• Sequence 1: NP_001285517.1
• Gene: Hlc / 33118
• FlyBaseID: FBgn0001565
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_778236.2
• Gene: DDX51 / 317781
• HGNCID: 20082
• Length: 666
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 99/421 - (23%)
• Similarity: 176/421 - (41%)
• Gaps: 103/421 - (24%)

  Fly    35 IQSTAIPLLLEG--------------KDVVVRARTGSGKTATYALPLIQKILNSKLNASEQYVSA 85
            :|:..||.|||.              .|:.|.|.||||||..:.:|::|.:|:..:    .::.|
Human   224 VQAAVIPALLESAACGFLVGRGGYRPSDLCVSAPTGSGKTLAFVIPVVQALLSRVV----CHIRA 284

  Fly    86 VVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVTQRHALSES-------PDIVVATP 143
            :|:.|||||.:|..||..  :.:....:||:.:....:....|...:.::       .|||||||
Human   285 LVVLPTKELAQQVSKVFN--IYTDATPLRVSLVTGQKSLAKEQESLVQKTADGYRCLADIVVATP 347

  Fly   144 ANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLI----------------------- 185
            ..|:.:.:......|:.:..|::||||.:....::....|::
Human   348 GRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAAFQSEDPADPCALLQRRQAQA 412

  Fly   186 --------KHLPPIYQAVLVSATLTDDVVRMKGLCLNNP--VTLKLEEPELVPQD---------- 230
                    ..:|  .|.:|.|||||.:..:::.|.|:.|  .:..|....|...|
Human   413 VTAASTCCPQMP--LQKLLFSATLTQNPEKLQQLGLHQPRLFSTGLAHRGLEDTDGDGDSGKYAF 475

  Fly   231 --QLSHQRILAEENDKP-AILYALLKLRLIRGKSIIFVNSIDRCYKVRLFLEQF-GIRACVLNSE 291
              .|:|..:....:.|| .:|:.:|::...|  .:.|.||.:..:::.|.::.| |:.....:|.
Human   476 PVGLTHHYVPCSLSSKPLVVLHLVLEMGFSR--VLCFTNSRENSHRLFLLVQAFGGVDVAEFSSR 538

  Fly   292 LPANIRIHTISQFNKGTYDIIIASDEHHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVI 356
            .....|...:.||.:|...::|::|                         :.:||||.|.|..|:
Human   539 YGPGQRRMILKQFEQGKIQLLISTD-------------------------ATARGIDVQGVELVV 578

  Fly   357 NFDFPRDVTSYIHRAGRTARGNNKGSVLSFV 387
            |:|.|:.:.:|:||.|||||....|...:.:
Human   579 NYDAPQYLRTYVHRVGRTARAGKTGQAFTLL 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	57/238 (24%)
		DEXDc	24..231	CDD:214692	60/261 (23%)
		HELICc	234..386	CDD:238034	38/153 (25%)
DDX51	NP_778236.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..152
		TMEM119	<79..159	CDD:292352
		PRK01297	109..609	CDD:234938	99/419 (24%)
		P-loop_NTPase	205..449	CDD:304359	56/232 (24%)
		Q motif	221..229		1/4 (25%)
		DEAD box	371..374		2/2 (100%)
		Helicase_C	489..600	CDD:278689	36/137 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010