DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hlc and Ddx31

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001028466.2	Gene:	Ddx31 / 227674	MGIID:	2682639	Length:	687	Species:	Mus musculus

Alignment Length:	613	Identity:	158/613 - (25%)
Similarity:	256/613 - (41%)	Gaps:	146/613 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FHELELDQRILKAV-AQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQKI--L 72
            |.||:|...::..: ..|.....|.:|..:||:||||:|.:||::||||||..|.:|::|.:  |
Mouse   105 FQELDLHPHLISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQAL 169

  Fly    73 NSKLNASE-QYVSAVVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVTQRHALSESP 136
            .||:..|: .|  |:||.||:||..||...:::|::....:  |..:........:::..|.:..
Mouse   170 TSKIQRSDGPY--ALVLVPTRELALQSFDTVQKLLKPFTWI--VPGVLMGGEKRKSEKARLRKGI 230

  Fly   137 DIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHLPPIYQA---VLVS 198
            :|:::||..|:.:.::...:....:..|:|||||.:...|:|||...::..:....|.   ||:|
Mouse   231 NILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNAECQKRQNVLLS 295

  Fly   199 ATLTDDVVRMKGLCLNNPVTLKL-------EEPELVPQDQLSHQRILAEENDKPAILYALLKLRL 256
            ||||:.|.|:..:.|:|||::.:       ..|:.|...||:...| .|..|:..:|.. .||||
Mouse   296 ATLTEGVTRLVDISLHNPVSISVLDKNCNQPNPKEVASIQLNSFAI-PESLDQHVVLVP-SKLRL 358

  Fly   257 I--------------RGKSIIFVNSIDRC-YKVRLFLEQFGIRACVLNSE-LPAN------IRIH 299
            :              ..|.|:|.:|.:.. :...|||......:....|| ||:.      :|:|
Mouse   359 VCLAAFILQKCKFEKNQKMIVFFSSCELVEFHYSLFLHTLLCHSGTPTSEHLPSASWPLKFLRLH 423

  Fly   300 ----------TISQFNKGTYDIIIASDEHHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNN 354
                      ...:|:.....:::.:|                         .||||:|...|..
Mouse   424 GNMEQEERTSVFHEFSHSETGVLLCTD-------------------------VASRGLDLPQVTW 463

  Fly   355 VINFDFPRDVTSYIHRAGRTARGNNKGSVLSFVSMKESK-VNDSVEKKLCDSFAAQEGEQIIKNY 418
            ::.:..|.....||||.|||||....||.|..::..|:: ||.....|:      ..||
Mouse   464 IVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASHKI------NVGE------ 516

  Fly   419 QFKMEEVESFRYRAQDCWRAATRVAVHD-----TRIREIKIEILNCEKLKAFFEENKRDLQALRH 478
             .|||::.:...: .||::...|.|...     ..|||      ....|:..||:.....|
Mouse   517 -IKMEDILAVLAK-DDCFKRRQRGAQKSRASGPQEIRE------RATVLQTVFEDYVHSSQ---- 569

  Fly   479 DKPLRAIK-----VQSHLSDMPEYIVPKALKRV-------VGTSSSPVGASEAKQPRQ---SAAK 528
                |.:.     :||.:.....|  ||.||.:       :|..:...|..:|  ||.   ||.|
Mouse   570 ----RMVSWAKKALQSFIRAYATY--PKELKSIFHVRALHLGHVAKSFGLRDA--PRNLSVSAVK 626

  Fly   529 AAFERQVNDPLMASQVDFGKRRPAHRRK 556
            .|                ..:||..|||
Mouse   627 KA----------------SLKRPHPRRK 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	70/215 (33%)
		DEXDc	24..231	CDD:214692	68/220 (31%)
		HELICc	234..386	CDD:238034	42/183 (23%)
Ddx31	NP_001028466.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	103..132		6/26 (23%)
		PRK04837	105..553	CDD:235314	132/498 (27%)
		P-loop_NTPase	105..317	CDD:304359	70/215 (33%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	261..264		2/2 (100%)
		HELICc	347..495	CDD:238034	39/173 (23%)
		DUF4217	557..618	CDD:290667	15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..687		7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010