Protein Alignment Hlc and C24H12.4

DIOPT Version :9

• Sequence 1: NP_001285517.1
• Gene: Hlc / 33118
• FlyBaseID: FBgn0001565
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_740966.1
• Gene: C24H12.4 / 173432
• WormBaseID: WBGene00016073
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 210/562 - (37%)
• Similarity: 329/562 - (58%)
• Gaps: 46/562 - (8%)

  Fly    11 FHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQKIL-NS 74
            |.:..||:||||::.:|||::...:|.:.|.|.||.|:::.|||||||||..:.:||:||:: .|
 Worm    91 FADFGLDERILKSIGELGWEKANQVQESVISLALENKNIMGRARTGSGKTGAFLIPLVQKLIAES 155

  Fly    75 KLNASEQYVSAVVLAPTKELCRQSRKVIEQLVESCG--KVVRVADIADSSNDTVTQRHALSESPD 137
            |.|......|||::||||||..|..|:..:|.::..  :.:.:.||.:..|..     .|.:...
 Worm   156 KTNDGSVGPSAVIIAPTKELITQIYKLFVKLSQALPFLQAINLCDINEEENSV-----WLEDRSH 215

  Fly   138 IVVATPANLLAYAEAGSVVDLKH-----VETLVVDEADLVFAYGYEKDFKRLIKHLPPIYQAVLV 197
            :||.||..||      .:..|:.     |..||:|||||:.::|||::..::...|||.||.::.
 Worm   216 VVVTTPGKLL------RMCSLRPEYCTLVSYLVMDEADLLLSFGYEEEMIKIRSKLPPTYQCLMT 274

  Fly   198 SATLTDDVVRMKGLCLNNPV-TLKLEEPELVPQDQLS-HQRILAEENDKPAILYALLKLRLIRGK 260
            ||||.||:..:|.|.:..|| |:||.|.:|...|||: :|.....:.::.|||.|:.||:||.|:
 Worm   275 SATLKDDMTTLKKLFMTGPVITIKLTEGDLPNSDQLTQYQLTCGSDEERFAILVAMFKLKLIVGR 339

  Fly   261 SIIFVNSIDRCYKVRLFLEQFGIRACVLNSELPANIRIHTISQFNKGTYDIIIASD------EHH 319
            ||:|||:||||||:.|.|..||:::|:|||.:|||.|.|.|:|||:|:|.|:||||      ...
 Worm   340 SILFVNTIDRCYKLMLILRVFGLKSCILNSAMPANSRCHVINQFNEGSYQIVIASDVSDADGSKL 404

  Fly   320 MEKPGGKSATN-RKSPRSG------DMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARG 377
            .|:..|||... .|..:.|      |.||..||||||..|:||:|||||....:||||.||||||
 Worm   405 KEEIAGKSDEKPEKDEKKGKKASKLDKESGVSRGIDFHHVSNVVNFDFPETTDAYIHRVGRTARG 469

  Fly   378 NNKGSVLSFVSMKESKVNDSVEKKLCDSFAAQEGEQIIKNYQFKMEEVESFRYRAQDCWRAATRV 442
            .|||:.|||....|....:.:::::    ..|.|.::::.|:|:::|:::|..|.::.....|:.
 Worm   470 FNKGTALSFCIPSERAHLEQIQEEI----NQQMGRKVLQPYEFRIKELDTFLLRTREALSKCTKG 530

  Fly   443 AVHDTRIREIKIEILNCEKLKAFFEENKRDLQALRHDKPLRAIKVQS-HLSDMPEYIVPKALKRV 506
            .:...|::||:.|::....|:.||.:|:|:...::.|.....:|:.| .::|:..|:||:||:
 Worm   531 VIKKARLKEIRQELMRSANLQTFFAKNEREKLLMQTDCHPVMLKINSPAIADVTSYMVPEALR-- 593

  Fly   507 VGTSSSPVGASEAK----QPRQSAAKAAFERQVNDPLMASQV 544
             |...|..||...:    |..:...|..|:::..|||...::
 Worm   594 -GMDFSAPGAKNRRYNMGQKHRQKLKHKFQKKGKDPLKTFKI 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	82/217 (38%)
		DEXDc	24..231	CDD:214692	79/215 (37%)
		HELICc	234..386	CDD:238034	82/164 (50%)
C24H12.4	NP_740966.1	SrmB	46..561	CDD:223587	191/484 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167203
Domainoid	1	1.000	145	1.000	Domainoid score	I2830
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6498
Inparanoid	1	1.050	352	1.000	Inparanoid score	I1328
Isobase	1	0.950	-	0	Normalized mean entropy	S843
OMA	1	1.010	-	-		QHG53986
OrthoDB	1	1.010	-	-		D209533at33208
OrthoFinder	1	1.000	-	-		FOG0004019
OrthoInspector	1	1.000	-	-		oto18813
orthoMCL	1	0.900	-	-		OOG6_102730
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R293
SonicParanoid	1	1.000	-	-		X2772
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890