DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hlc and B0511.6

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_492779.1	Gene:	B0511.6 / 172954	WormBaseID:	WBGene00015232	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	148/560 - (26%)
Similarity:	254/560 - (45%)	Gaps:	107/560 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQMTQKTVQFHELE--LDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATY 63
            :|:...||. |..||  ::..:||||..||:...|.||:.:|..|||||||:..|:||||||..:
Worm    59 VSEFLTKTT-FASLEGKVNANLLKAVQGLGFTTMTEIQAKSIDPLLEGKDVLASAKTGSGKTLAF 122

  Fly    64 ALPLIQKILNSKLNASEQY-VSAVVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVT 127
            .||.|:  |..|||..:.. ...::::||:||..|:..|:.:|:|  |..:....:...||.: .
Worm   123 LLPAIE--LLHKLNWKQHNGTGVIIVSPTRELSMQTYGVLSELLE--GSNLTYGLVMGGSNRS-A 182

  Fly   128 QRHALSESPDIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHLPPIY 192
            ::..|::...|:||||..||.:.:......:::::.|::||||.:...|:|.:.:::::|||...
Worm   183 EKDKLAKGVSILVATPGRLLDHLQNTDNFLVRNMKCLIIDEADRILDIGFEIEMQQVLRHLPKQR 247

  Fly   193 QAVLVSATLTDDVVRMKGLCL-NNPVTLKL-EEPELVPQDQLSHQRILAEENDKPAILYALLKLR 255
            |::|.|||.:..|..:..|.| :|||.:.: |:.|....:.|....|:|..:.:..:|:..||..
Worm   248 QSMLFSATHSPKVDELVKLALHSNPVRVSVHEKAEEATVEGLQQGYIVAPSDKRLLLLFTFLKKN 312

  Fly   256 LIRGKSIIFVNSIDRCYKVRL---FLEQFGIRACVLNSELPANIRIHTISQFNKGTYDIIIASDE 317
            ..: |.::|.:|   |..|:.   .|....|....::.:.....|..|..||.:....|::.:|
Worm   313 KTK-KVMVFFSS---CNSVKFHHELLNYIDIPCMSIHGKQKQQKRTTTFFQFCQAETGILLCTD- 372

  Fly   318 HHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARGNN--- 379
                                    .|:||:|...|:.::.:|...:...||||.||||||.|
Worm   373 ------------------------VAARGLDIPAVDWIVQYDPTDEPREYIHRVGRTARGTNGSG 413

  Fly   380 ------KGSVLSFVS-MKESKV--ND---------SVEKKLCDSFAAQEGEQII-KNYQFKMEEV 425
                  :...|.|:. :|.:||  |:         :::.:|         |.:| |||.......
Worm   414 KALLVLRPEELGFLRYLKAAKVTLNEFEFSWSKVANIQSQL---------ENLISKNYYLNKSAK 469

  Fly   426 ESFRYRAQDCWRAATRVAVHDTRIREIKIEILNCEKLKAFFEENKRDLQALRHDKPLRAIKVQSH 490
            |:::     |:..|     :|:            ..||..|:....||.|:.          :|.
Worm   470 EAYK-----CYLRA-----YDS------------HSLKDIFDVTNMDLTAVS----------KSF 502

  Fly   491 LSDMPEYI-VPKALKRVVGTSSSPVGASEAKQPRQSAAKA 529
            ...:|.:: :|.:.|..|...|...||...|:.:....||
Worm   503 GFSVPPFVDLPISNKPKVEIRSKLSGAGYRKKKQSFTFKA 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	74/212 (35%)
		DEXDc	24..231	CDD:214692	70/209 (33%)
		HELICc	234..386	CDD:238034	36/163 (22%)
B0511.6	NP_492779.1	DEADc	68..276	CDD:238167	74/212 (35%)
		DEXDc	83..291	CDD:214692	71/212 (33%)
		Helicase_C	312..407	CDD:278689	26/123 (21%)
		DUF4217	450..508	CDD:290667	17/98 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920