Protein Alignment Hlc and ddx-10

DIOPT Version :9

• Sequence 1: NP_001285517.1
• Gene: Hlc / 33118
• FlyBaseID: FBgn0001565
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_490989.1
• Gene: ddx-10 / 171810
• WormBaseID: WBGene00021277
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 567
• Identity: 139/567 - (24%)
• Similarity: 252/567 - (44%)
• Gaps: 106/567 - (18%)

  Fly     3 QMTQKT----VQFHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATY 63
            :|.:|:    ::|.:..|..|.|:.:....:.:||.||...|...|.|.|||..|:||||||...
 Worm    66 EMLKKSSRTFLRFEDFPLSWRTLEGLKDNDYTKPTEIQRDTIAYSLTGSDVVGAAKTGSGKTLAL 130

  Fly    64 ALPLIQKILNSKLNASEQY-VSAVVLAPTKELCRQSRKVIEQLVE----SCGKVVRVADIADSSN 123
            .:|:::.:..:|.  |..| :.|::::||:||..|:...|..:..    |||.|:..:|:|
 Worm   131 VIPVLEALWRAKW--SPDYGLGALIISPTRELALQTFSTINAVGAHHGFSCGLVIGGSDVA---- 189

  Fly   124 DTVTQRHALSESPDIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHL 188
               .:|:.:| ..:|:|.||..||.:.:..:.:....::.||:||||.:...|:.|....:|.:|
 Worm   190 ---FERNRIS-GINIIVCTPGRLLQHMDENAQMSCDSLQVLVLDEADRMLDMGFSKQLNSIINNL 250

  Fly   189 PPIYQAVLVSATLTDDVVRMKGLCLNNPVTLKL-EEPELVPQDQLSHQRILAEENDKPAILYALL 252
            |...|.:|.|||.|.:|..:..:|.|:||.:.: |.......|.|....::.||..|...|::.:
 Worm   251 PAERQTLLFSATQTRNVKDLCRVCTNDPVFVSVHENASAATPDNLKQSYVIVEEEHKINALWSFI 315

  Fly   253 KLRLIRGKSIIFVNSIDRCYKVRLFLEQF-----GIRACVLNSELPANIRIHTISQFNKGTYDII 312
            :... :.||::||:|   |.:.|...|.|     |:....|...:....||.|.::|::....::
 Worm   316 EAHR-KKKSLVFVSS---CKQARFLTEAFSQLRPGLPVMGLWGTMNQKKRIETFTKFDESKAAVL 376

  Fly   313 IASDEHHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARG 377
            ||:|                         .||||:||:.::.||..|.|..:..||||.||:||.
 Worm   377 IATD-------------------------VASRGLDFEHIDWVIQVDCPAQIDDYIHRVGRSARM 416

  Fly   378 NNKGSVLSFVSMKESKVNDSVEKKLCDSFAAQEGEQI--IKNYQFKMEEVESFRYRAQDCWRAAT 440
            ::.|:.|..||                  .:||...|  ::.:...:||::
 Worm   417 DDSGNSLLMVS------------------PSQEEAMIGKLEKHSIPIEELK-------------- 449

  Fly   441 RVAVHDTRIREIKIE----ILNCEKLKAFFEEN----KRDLQALRHDK--PLRAIKVQSHLSDMP 495
               :|...:.:::::    :...::||.:.:::    .|.:..::..|  .:.||...:......
 Worm   450 ---IHPDAMSDVRVKLRAILAESQELKEYAQKSIVAYLRSIYTMKDKKVFDVEAIDAAALADSFG 511

  Fly   496 EYIVPKA--LKRVVGTSSSPVGASEAKQPRQSAA---KAAFERQVND 537
            ...||:.  |.:....|...:...|.|:..:.|:   |.|.:....|
 Worm   512 LVSVPRVRFLNKKAKKSGEKLMEKEVKEEEEEASLVGKFAIDEDDED 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	68/213 (32%)
		DEXDc	24..231	CDD:214692	65/212 (31%)
		HELICc	234..386	CDD:238034	42/156 (27%)
ddx-10	NP_490989.1	SrmB	52..511	CDD:223587	129/518 (25%)
		DEADc	78..282	CDD:238167	68/213 (32%)
		Helicase_C	305..416	CDD:278689	37/139 (27%)
		DUF4217	461..517	CDD:290667	7/55 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920