DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hlc and Ddx1

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_598801.1	Gene:	Ddx1 / 104721	MGIID:	2144727	Length:	740	Species:	Mus musculus

Alignment Length:	654	Identity:	123/654 - (18%)
Similarity:	203/654 - (31%)	Gaps:	301/654 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQ------ 69
            |.|:.:...|.:||.::.|..||.||:.:|||:|.|.||::.|.||||||..:::|:||
Mouse     4 FSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETL 68

  Fly    70 -----------------KILNS------------------------------------------- 74
                             .:||.
Mouse    69 KDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRGTRGLLKGKH 133

  Fly    75 ----------------------------------------------------------------- 74

Mouse   134 YYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDI 198

  Fly    75 ----------------------------------------KLN-------------------ASE 80
                                                    |.|                   |.:
Mouse   199 DKGHVKFSKNGKDLGLAFEIPAHIKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPD 263

  Fly    81 QYV---------------------SAVVLAPTKELCRQSRKVIEQLVE-----SCGKVVRVADIA 119
            .|:                     .|:::.|::||..|:...::|..:     ...:::.:..:|
Mouse   264 NYIVKSQHTGNAQVSQTKFLPNAPKALIVEPSRELAEQTLNNVKQFKKYIDNPKLRELLIIGGVA 328

  Fly   120 DSSNDTVTQRHALSESPDIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRL 184
              :.|   |...|....||||.||..|......|. ::|..|..||:||||.:.:.||.....|:
Mouse   329 --ARD---QLSVLDNGVDIVVGTPGRLDDLVSTGK-LNLSQVRFLVLDEADGLLSQGYSDFINRM 387

  Fly   185 IKHLPPI------YQAVLVSATL-TDDVVRMKGLCLNNPVTLKLEEPELVPQ------------- 229
            ...:|.|      .|.::.|||| :.||.::....::.|..:.|:..:.||.
Mouse   388 HNQIPQITCDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKT 452

  Fly   230 DQL------SHQR---ILAEENDKPA------------ILYALLKLRLIR----GKSIIFVNSID 269
            |:|      :|.|   :.|::|.:|.            ||.....:|.|:    .::|||..:..
Mouse   453 DKLWERLGKNHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKI 517

  Fly   270 RCYKV-RLFLEQFG-------IRACV-LNSELPANIRIHTISQFNKGTYDIIIASDEHHMEKPGG 325
            .|..: :.|::|.|       ..:|| |:.:...:.|...:.:|.||....:|.:|
Mouse   518 DCDNLEQYFMQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTD--------- 573

  Fly   326 KSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARGNNKGSVLSFVSMK 390
                            .|:||||...|..|||...|.:..:|:||.||..|....|..:|.|:.:
Mouse   574 ----------------VAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATE 622

  Fly   391 ESKV 394
            :.||
Mouse   623 KEKV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	72/431 (17%)
		DEXDc	24..231	CDD:214692	71/442 (16%)
		HELICc	234..386	CDD:238034	42/179 (23%)
Ddx1	NP_598801.1	Necessary for interaction with RELA. /evidence=ECO:0000250\|UniProtKB:Q92499	1..525		90/526 (17%)
		Interaction with dsRNA. /evidence=ECO:0000269\|PubMed:21703541	1..448		75/449 (17%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250\|UniProtKB:Q92499	1..295		34/290 (12%)
		P-loop_NTPase	4..>72	CDD:304359	27/67 (40%)
		SPRY_DDX1	93..245	CDD:293933	2/151 (1%)
		SrmB	284..>624	CDD:223587	88/370 (24%)
		P-loop_NTPase	<284..426	CDD:304359	38/147 (26%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)
		Helicase_C	493..609	CDD:278689	33/140 (24%)
		Necessary for interaction with HNRNPK. /evidence=ECO:0000250\|UniProtKB:Q92499	525..740		33/127 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010