DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hlc and Ddx55

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001258255.1	Gene:	Ddx55 / 100362764	RGDID:	2324094	Length:	600	Species:	Rattus norvegicus

Alignment Length:	418	Identity:	107/418 - (25%)
Similarity:	193/418 - (46%)	Gaps:	60/418 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQMTQKTVQFHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYAL 65
            |..:|:.:.:..::.|...:|.|:.:||:...|.:||..|||.:..|||...|.||||||..:.:
  Rat     1 MEHVTEGSWESLQVPLHPLVLGALRELGFLHMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVI 65

  Fly    66 PLIQKILNSKLNASEQYVSAVVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVTQRH 130
            |:::.:|..:....:..|.|:|:.||:||..|..:|:....:...:..::..|...:.....:|.
  Rat    66 PILEILLRREEKLKKNQVGAIVITPTRELAIQIDEVLSHFTKHFPQFSQILWIGGRNPGEDVERF 130

  Fly   131 ALSESPDIVVATPANLL-AYAEAGSVVDL----KHVETLVVDEADLVFAYGYEKDFKRLIKHLPP 190
            . ....:|:||||..|. .:......:||    |.::.||:||||.:...|:|.....:::.||.
  Rat   131 K-QHGGNIIVATPGRLEDMFRRKAEGLDLASYVKSLDVLVLDEADRLLDMGFEASINTILEFLPK 194

  Fly   191 IYQAVLVSATLTDDVVRMKGLCLNNPVTLKLEEPELVPQ------DQLSHQRILAEENDKPAILY 249
            ..:..|.|||.|.:|..:....|.|||.:.::|..:...      .:|.:..::.:.::|...|.
  Rat   195 QRRTGLFSATQTQEVENLVRAGLRNPVRISVKEKGVAASSTQKTPSRLENHYMICKADEKFNQLV 259

  Fly   250 ALLKLRLIRGKSIIFVNSIDRCYKVRLFLEQFG--IRACVLNSELPANIRIH---------TISQ 303
            ..|:.|. :.|.::|.::. .|      :|.:|  :.|.|...::   :.||         ...:
  Rat   260 HFLRSRQ-QEKHLVFFSTC-AC------VEYYGKALEALVQRVKI---LCIHGKMKYKRNKIFME 313

  Fly   304 FNKGTYDIIIASDEHHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYI 368
            |.|....|::.:|                         ..:||||...||.|:.:|.|.:.::::
  Rat   314 FRKLQSGILVCTD-------------------------VMARGIDIPEVNWVLQYDPPSNASAFV 353

  Fly   369 HRAGRTARGNNKGSVLSF-VSMKESKVN 395
            ||.|||||..:.||.|.| :.|:|:.:|
  Rat   354 HRCGRTARIGHGGSALVFLLPMEEAYIN 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	63/213 (30%)
		DEXDc	24..231	CDD:214692	61/217 (28%)
		HELICc	234..386	CDD:238034	36/162 (22%)
Ddx55	NP_001258255.1	DEADc	9..224	CDD:238167	63/215 (29%)
		DEXDc	24..228	CDD:214692	60/204 (29%)
		Helicase_C	252..363	CDD:278689	33/146 (23%)
		DUF4217	403..462	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010