DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slgA and Prodh2

DIOPT Version :9

Sequence 1:	NP_001245796.1	Gene:	slgA / 33117	FlyBaseID:	FBgn0003423	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001033677.1	Gene:	Prodh2 / 361538	RGDID:	1306761	Length:	456	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	173/549 - (31%)
Similarity:	265/549 - (48%)	Gaps:	130/549 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 AFKSKTTGELIRAYLVYMICSSEKLVEHNMTLMKWSKNVLGQRLFTLLMKATFYGHFVAGEDQIK 188
            ||..|.|.||.||.||..:|:...||.|.:....||:.:||.||...|::|:.||.|||||...:
  Rat    28 AFHLKRTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEE 92

  Fly   189 IIPTLERLRSFGVKPILDYSVEEDITQEEAEKREVESSVSSAGDKKEEGSMPQYHVDKSFADRRY 253
            :...:::|::.|::|:|....||:                           |.
  Rat    93 VRGCVQQLQAIGLQPLLAVPTEEE---------------------------PD------------ 118

  Fly   254 KVSSARTYFYLNEATCERNMEIFIKCLE---AVSDDDRKAPRAVATGATFGTGITAIKLTALGRP 315
              |:|:|    :||..|.|:...:.|::   ||:|....|..:          :..:|:|||..|
  Rat   119 --SAAKT----SEAWYEGNLSAMLHCVDLSRAVADAHGPARNS----------LMQLKVTALTSP 167

  Fly   316 QLLLQLSEVIMRTRKYMEDMVGGQGNVLTHHKTIKDLEKYYATLGDNKDVKEFLNNVTSDKEGIL 380
            :|..:||..|.|.|                                                |..
  Rat   168 RLCKELSAWIQRPR------------------------------------------------GSS 184

  Fly   381 HLFPWSGIVDEDSQLSDTFRVPDPQTGQMRRLISQIPPKEEEMFRNMIRRLNTIVKAAADLDVRI 445
            .|.|        .:|::..     ::|:..:| |.:..::.:..:..:.||:.:.:.|...|||:
  Rat   185 ELRP--------ERLAEAM-----ESGRNLQL-SCLSTEQNQHLQASLSRLHRVAQHARAQDVRL 235

  Fly   446 MVDAEQTYFQPAISRITLEMMRKYN---KDKAIVFNTYQCYLRETFREVNTDLEQAKRQNFYFGA 507
            :||||.|:..||:|.:...:..::|   ::...|:||||.||::|...:..|.:.|......||.
  Rat   236 LVDAEYTFINPALSLLVAALAMRWNSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGV 300

  Fly   508 KLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSECLRRIKLMKDCDDDARKIGIMVAS 572
            |||||||:|:||...:..|..|...|.:|||:..|.|.|...|||:      .:...:..:||||
  Rat   301 KLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRV------SNHGPRCHLMVAS 359

  Fly   573 HNEDTVRFAIQQMKEIGISPEDKVICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLS 637
            |||:::|.|.::|.|:|| |.|..:||||||||||:::..||||||..||.||||.:|||:|||.
  Rat   360 HNEESIRQATRRMWELGI-PLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLI 423

  Fly   638 RRAQENKGVLKKIKKEKRLLLSEIRRRLM 666
            ||||||:.||:..::|:.||..|:.|||:
  Rat   424 RRAQENRSVLQGARREQALLSQELWRRLL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slgA	NP_001245796.1	PLN02681	93..668	CDD:215366	173/549 (32%)
slgA	NP_001245796.1	Pro_dh	417..653	CDD:279895	100/238 (42%)
Prodh2	NP_001033677.1	PLN02681	28..453	CDD:215366	173/549 (32%)
Prodh2	NP_001033677.1	Pro_dh	218..439	CDD:279895	100/227 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53936
OrthoDB	1	1.010	-	-		D392857at33208
OrthoFinder	1	1.000	-	-		FOG0001607
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101295
Panther	1	1.100	-	-	O	PTHR13914
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.930