DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slgA and prdh-1

DIOPT Version :9

Sequence 1:	NP_001245796.1	Gene:	slgA / 33117	FlyBaseID:	FBgn0003423	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_502669.2	Gene:	prdh-1 / 178350	WormBaseID:	WBGene00007197	Length:	616	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	271/579 - (46%)
Similarity:	373/579 - (64%)	Gaps:	51/579 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LDVSFNDPIAAFKSKTTGELIRAYLVYMICSSEKLVEHNMTLMKWSKNVLGQRLFTLLMKATFYG 178
            ||:||.:...|||||:..||:||.:|..:|..:.||..|..::...:.|||:.||...:|.||:|
Worm    57 LDLSFENTKEAFKSKSNTELVRALVVLRLCGIQTLVNQNQIILNTMRRVLGKNLFKKTLKNTFFG 121

  Fly   179 HFVAGEDQIKIIPTLERLRSFGVKPILDYSVEEDITQEEAEKREVE-SSVSS---------AGDK 233
            ||||||.:.::...:|:||::|||.|||||||.|||.:||..:.|: :||::         ...|
Worm   122 HFVAGETEEEVRHVVEKLRNYGVKSILDYSVEADITSQEATDKTVKGTSVATVKPAAMTPVVDAK 186

  Fly   234 KEEGSMPQYHVDKSFADRRYKVSSARTYFYLNEATCERNMEIFIKCLEAVSDDDRKAPRAVATGA 298
            ..|.:..:|.|.:.|.|||..|||||||||..|..|::|.:||...:.||:            .|
Worm   187 TLETTRERYTVHEEFGDRRQGVSSARTYFYEGEEQCDKNRDIFKDSINAVA------------SA 239

  Fly   299 TFGTGITAIKLTALGRPQLLLQLSEVIMRTRKYMEDMVGG---QGNVLTHHKTIKDLEKYYATLG 360
            |...|..|:|:||||||||||:|||.|::|:.:.:.:.||   |...||.       :::|..||
Worm   240 TKNEGFVAVKITALGRPQLLLKLSEAIVQTQNFFKALTGGMSLQEGRLTS-------QEFYKRLG 297

  Fly   361 ------DNKDVKEFLNNVTSDKEGILHLFPWSGIVDEDSQLSDTFRVPDPQTGQMRRLISQIPPK 419
                  |.:.||:|.:.|..|.:||:.|..|:.|:|:..:|...|:|.:.:||.:..||..:..:
Worm   298 ELGVKTDTESVKKFFDEVDFDSDGIVDLHGWNHILDDHVKLGQLFQVLNIKTGSLEPLIQNLSNE 362

  Fly   420 EEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAISRITLEMMRKYNKDKAIVFNTYQCYL 484
            ||:.||||:||...:.:.|.:..|||||||||||.|||||:||:|||:||||.:..:|||||.||
Worm   363 EEQEFRNMVRRTLDVAEYAIEKGVRIMVDAEQTYLQPAISKITIEMMKKYNKGRGNIFNTYQAYL 427

  Fly   485 RETFREVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTLSEC 549
            :.|.:.:..|::.|:|:.::|||||||||||:|||.|||::||.||:|..||||:.||    ..|
Worm   428 KGTLQNMEADMQVARREGWHFGAKLVRGAYMEQERARAKAIGYEDPINDNFEATSKMY----ESC 488

  Fly   550 LRRIKLMKDCDDDARK----IGIMVASHNEDTVRFAIQQMKEIGISPEDKVICFGQLLGMCDYIT 610
            |.||     .|:..|:    :.:|||||||||||||:..|||..|||.::|:|..||.||||.::
Worm   489 LTRI-----ADEVHRRGKTNVSVMVASHNEDTVRFALNLMKEKCISPSERVMCMAQLYGMCDQVS 548

  Fly   611 FPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKGVLKKIKKEKRLLLSEIRRRLMRGQ 669
            |.|||||:|.|||:||||||||||||||||.||..||||..||:.||..|::||:..|:
Worm   549 FSLGQAGFSVYKYLPYGPVEEVLPYLSRRALENGSVLKKANKERDLLWKELKRRISSGE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slgA	NP_001245796.1	PLN02681	93..668	CDD:215366	270/576 (47%)
slgA	NP_001245796.1	Pro_dh	417..653	CDD:279895	138/239 (58%)
prdh-1	NP_502669.2	PLN02681	58..604	CDD:215366	269/573 (47%)
		EFh	<285..325	CDD:298682	13/46 (28%)
		Pro_dh	347..592	CDD:279895	143/253 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161754
Domainoid	1	1.000	356	1.000	Domainoid score	I514
eggNOG	1	0.900	-	-		E1_COG0506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40764
Inparanoid	1	1.050	493	1.000	Inparanoid score	I773
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53936
OrthoDB	1	1.010	-	-		D392857at33208
OrthoFinder	1	1.000	-	-		FOG0001607
OrthoInspector	1	1.000	-	-		oto19503
orthoMCL	1	0.900	-	-		OOG6_101295
Panther	1	1.100	-	-	LDO	PTHR13914
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R983
SonicParanoid	1	1.000	-	-		X1170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840