DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slgA and prodhb

DIOPT Version :9

Sequence 1:	NP_001245796.1	Gene:	slgA / 33117	FlyBaseID:	FBgn0003423	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_017211719.1	Gene:	prodhb / 100537991	ZFINID:	ZDB-GENE-101116-1	Length:	603	Species:	Danio rerio

Alignment Length:	604	Identity:	270/604 - (44%)
Similarity:	395/604 - (65%)	Gaps:	43/604 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 SETVKRSMKQESSQEKNPSPAGSPQRDPLDVSFNDPIA--------AFKSKTTGELIRAYLVYMI 142
            :.|.:....:.::||::   ..|.:.|    |||..|:        |:|||.|.||:|:.:|:.:
Zfish    26 TSTCRYHQTKTNTQEES---VNSSEHD----SFNSKISIDFELTREAYKSKDTLELLRSLVVFKL 83

  Fly   143 CSSEKLVEHNMTLMKWSKNVLGQRLFTLLMKATFYGHFVAGEDQIKIIPTLERLRSFGVKPILDY 207
            ||.:.||:.|..::..|:.:|||::|...||.||||.||||||...|.|.:::.:::||..:|||
Zfish    84 CSYDILVDKNKEIIDLSRKLLGQKMFEQFMKMTFYGQFVAGEDHQSIRPVVQKNQAYGVGAVLDY 148

  Fly   208 SVEEDITQEEAEKREVESSVSSAGDKKEEG---SMPQYHVDKSFADRRYKVSSARTYFYLNEATC 269
            |||||::|||||::|:||.:|:: :|:..|   ...::...:.|.|||..|:|||||||.:||.|
Zfish   149 SVEEDLSQEEAERKEMESCMSTS-EKESPGVDHREKKFTAHRRFGDRREGVTSARTYFYADEAKC 212

  Fly   270 ERNMEIFIKCLEAVSDDDRKAPRAVATGATFGTGITAIKLTALGRPQLLLQLSEVIMRTRKYMED 334
            :::||.|:.|::             |:|.:...|.:|||:|||||||.|||.|||:::.|::...
Zfish   213 DQHMETFLNCIK-------------ASGGSSEDGFSAIKMTALGRPQFLLQFSEVLVKWRRFFSF 264

  Fly   335 MVGGQG----NVLTHHKTIKDLEKYYATLGDNKDVKEFLNNVTSDKEGILHLFPWSGIVDEDSQL 395
            :...||    .||.....::.|:...|.||...:::.|.::......||:.:..|:.::||..::
Zfish   265 LASKQGKDGMEVLEQKLDLEQLQMCLARLGAEGNIQSFFSDGRLHSSGIVDMLDWNRLIDERMKI 329

  Fly   396 SDTFRVPDPQTGQMRRLISQIPPKEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAISR 460
            ||...||:.||||:..|:|:...:||...:.|::||:.:.|.|.:..||:|||||||||||||||
Zfish   330 SDLLVVPNLQTGQLEPLLSRFTEEEERQMKRMLQRLDVLAKHAVENGVRLMVDAEQTYFQPAISR 394

  Fly   461 ITLEMMRKYNKDKAIVFNTYQCYLRETFREVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSL 525
            :|:||.|.:|:|||:|||||||||:|.|..|:.|:|.::|:.:.|.|||||||||.|||.||..:
Zfish   395 LTVEMKRSFNRDKAVVFNTYQCYLKEAFDNVSMDVELSRREGWCFAAKLVRGAYMYQERSRAAEI 459

  Fly   526 GYPDPVNPTFEATTDMYHRTLSECLRRIKLMKDCDDDARKIGIMVASHNEDTVRFAIQQMKEIGI 590
            ||.||:||.:|:|..||||.|...|..|:..|       |:.:||||||.|||:..:::|.|:|:
Zfish   460 GYEDPINPDYESTNRMYHRCLDYVLEEIQRNK-------KVNVMVASHNLDTVKHTLRRMNEMGL 517

  Fly   591 SPEDKVICFGQLLGMCDYITFPLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKGVLKKIKKEKR 655
            .|.||.:||||||||||.|:|||.|||:..|||:|||||.||:||||||||||:|.:|.::.|:.
Zfish   518 QPTDKKVCFGQLLGMCDQISFPLAQAGFPVYKYVPYGPVNEVIPYLSRRAQENRGFMKGVQMERE 582

  Fly   656 LLLSEIRRRLMRGQLFYKP 674
            ||..|:.|||..||:.|.|
Zfish   583 LLWKELMRRLSSGQILYTP 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slgA	NP_001245796.1	PLN02681	93..668	CDD:215366	265/589 (45%)
slgA	NP_001245796.1	Pro_dh	417..653	CDD:279895	133/235 (57%)
prodhb	XP_017211719.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I976
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40764
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1292
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392857at33208
OrthoFinder	1	1.000	-	-		FOG0001607
OrthoInspector	1	1.000	-	-		otm24531
orthoMCL	1	0.900	-	-		OOG6_101295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R983
SonicParanoid	1	1.000	-	-		X1170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900