DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slgA and prodha

DIOPT Version :9

Sequence 1:	NP_001245796.1	Gene:	slgA / 33117	FlyBaseID:	FBgn0003423	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_005161051.2	Gene:	prodha / 100333321	ZFINID:	ZDB-GENE-041008-73	Length:	629	Species:	Danio rerio

Alignment Length:	583	Identity:	269/583 - (46%)
Similarity:	380/583 - (65%)	Gaps:	44/583 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LDVSFNDPIAAFKSKTTGELIRAYLVYMICSSEKLVEHNMTLMKWSKNVLGQRLFTLLMKATFYG 178
            :.:.|::...|::||.|.||:|:.||:.:|:.:.||:.|..|:..||.:||||||..|||.||||
Zfish    67 ISIDFDNTREAYRSKHTLELLRSLLVFKLCTFDFLVDKNKELIDLSKKILGQRLFEKLMKMTFYG 131

  Fly   179 HFVAGEDQIKIIPTLERLRSFGVKPILDYSVEEDITQEEAEKREVESSVSSAGDKKE-----EGS 238
            .|||||||..|.|.:|:.::|||..:||||||||:|||||||:|::|.||.|  :||     ...
Zfish   132 QFVAGEDQNSIKPLIEKNQAFGVGSVLDYSVEEDLTQEEAEKKEMDSCVSEA--EKESHVDTHAC 194

  Fly   239 MPQ-----------YHVDKSFADRRYKVSSARTYFYLNEATCERNMEIFIKCLEAVSDDDRKAPR 292
            .||           |...:.|.|||..|.|||||||.:||.|:.:||.||.|::|
Zfish   195 SPQDPECMDHREKKYKAHRQFGDRRGGVISARTYFYADEAKCDHHMETFINCIKA---------- 249

  Fly   293 AVATGATFGTGITAIKLTALGRPQLLLQLSEVIMRTRKYMEDMVGGQGN----VLTHHKTIKDLE 353
              :.|::. .|.:|||:|||||||.|||.|||:::.|::...:...||.    ||.....::.|:
Zfish   250 --SAGSSV-DGFSAIKMTALGRPQFLLQFSEVLVKWRRFFTLLAAHQGKDGMAVLEQKLELQQLQ 311

  Fly   354 KYYATL--GDNKDVKEFLNNVTSDKEGILHLFPWSGIVDEDSQLSDTFRVPDPQTGQMRRLISQI 416
            .....|  |...|::.:.........|.:.|..|:.::::.:::|:...||:.::|.:..|:|:.
Zfish   312 DSLIKLGVGAKSDIENWFTGEELGSSGTIDLLDWNSLINDRTKISNLLVVPNMESGHLEPLLSKF 376

  Fly   417 PPKEEEMFRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAISRITLEMMRKYNKDKAIVFNTYQ 481
            ..:||:..:.|::|::.:.|.|.:..||:|||||||||||||||:||||.|.:|::|..:|||||
Zfish   377 TDEEEKQMKRMLQRMDVLAKHAVENGVRLMVDAEQTYFQPAISRLTLEMQRIFNREKPHIFNTYQ 441

  Fly   482 CYLRETFREVNTDLEQAKRQNFYFGAKLVRGAYMDQERDRAKSLGYPDPVNPTFEATTDMYHRTL 546
            |||||.:..|:.|:|.::|:.:||||||||||||.|||.||..:||.||:||.:|||.:|||:.|
Zfish   442 CYLREAYDNVSVDVELSRREGWYFGAKLVRGAYMCQERSRASEIGYEDPINPDYEATNNMYHKCL 506

  Fly   547 SECLRRIKLMKDCDDDARKIGIMVASHNEDTVRFAIQQMKEIGISPEDKVICFGQLLGMCDYITF 611
            ...|..|       :..|...:||||||||||:|.:::|.|:.:||.:..:.|||||||||.|:|
Zfish   507 EYILEEI-------NHNRMANVMVASHNEDTVKFTLEKMNEMNLSPTENKVYFGQLLGMCDQISF 564

  Fly   612 PLGQAGYSAYKYIPYGPVEEVLPYLSRRAQENKGVLKKIKKEKRLLLSEIRRRLMRGQLFYKP 674
            ||||||:..|||:|||||.||:||||||||||:|.:|..::|:.||..||:|||..|||.|.|
Zfish   565 PLGQAGFPVYKYVPYGPVNEVIPYLSRRAQENRGFMKGSQRERSLLWKEIKRRLFSGQLLYTP 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slgA	NP_001245796.1	PLN02681	93..668	CDD:215366	264/575 (46%)
slgA	NP_001245796.1	Pro_dh	417..653	CDD:279895	131/235 (56%)
prodha	XP_005161051.2	PLN02681	68..619	CDD:215366	263/572 (46%)
prodha	XP_005161051.2	Pro_dh	377..601	CDD:279895	130/230 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585530
Domainoid	1	1.000	351	1.000	Domainoid score	I976
eggNOG	1	0.900	-	-		E1_COG0506
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1292
OMA	1	1.010	-	-		QHG53936
OrthoDB	1	1.010	-	-		D392857at33208
OrthoFinder	1	1.000	-	-		FOG0001607
OrthoInspector	1	1.000	-	-		otm24531
orthoMCL	1	0.900	-	-		OOG6_101295
Panther	1	1.100	-	-	LDO	PTHR13914
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770