DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and sept3

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001019589.2	Gene:	sept3 / 554123	ZFINID:	ZDB-GENE-050522-375	Length:	361	Species:	Danio rerio

Alignment Length:	301	Identity:	147/301 - (48%)
Similarity:	206/301 - (68%)	Gaps:	10/301 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQKQTVK 78
            ||:|...:..|:.:|::|.||:|.:||||:||||||||||:||.:.:..........||..:||:
Zfish    52 GYIGIDTIIEQMRKKTMKAGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRRSTSWSRDEKIPKTVE 116

  Fly    79 LEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNR-RNIVDN 142
            :::.:..|||.|||::|||||||||||.|:|.|.:..|.::|:||||:||::|..:.| :.|.|.
Zfish   117 IKSVSHVIEEGGVKMKLTVVDTPGFGDQINNDNCWEPISKHINEQYEKFLKEEVNIARKKRIPDT 181

  Fly   143 RIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESHGIK 207
            |:|||.|||||.||.|:.||:||||.|...|||:|||||:|.||.:|....|.|:.:|:|..||:
Zfish   182 RVHCCLYFISPTGHSLRQLDIEFMKHLSRVVNIIPVIAKSDTLTPEEKTEFKQRVRKELEVCGIE 246

  Fly   208 IYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENPDHCDFI 272
            .|  |..:.|||.:.|....:::|.:||||.|::...:|.||:|.||...|||||||||:||:|.
Zfish   247 CY--PQKEFDEDMEDKSDNDKIRETMPFAVVGSDKEYQVNGKRVLGRKTAWGVVEVENPNHCEFS 309

  Fly   273 KLRTMLI-THMQDLQEVTQEVHYENYRSDRLAKGIKGKENG 312
            .||..:| :|:|||:|||..:|||.||:.||      .:||
Zfish   310 LLRDFMIRSHLQDLKEVTHNIHYETYRAKRL------NDNG 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	147/301 (49%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	139/273 (51%)
sept3	NP_001019589.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		CDC_Septin	70..344	CDD:206649	139/281 (49%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	80..87		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	137..140		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	219..222		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..361		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850