DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and sept2

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001288289.1	Gene:	sept2 / 323457	ZFINID:	ZDB-GENE-030131-911	Length:	369	Species:	Danio rerio

Alignment Length:	359	Identity:	255/359 - (71%)
Similarity:	303/359 - (84%)	Gaps:	12/359 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FSSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIE 71
            |::.|||||||||||||||||||||||||||||||||||||||||:||||||||||||:||.|.|
Zfish    13 FTNPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAE 77

  Fly    72 KQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNR 136
            |.::||::|||||||||||||||||||||||:||||::.:.|..|:.|||:|:||:|.|||||||
Zfish    78 KIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINSQDCFNTIISYIDDQFERYLHDESGLNR 142

  Fly   137 RNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEI 201
            |:|||||:|||||||||.|||||||||:|||.:|:|||:||||||||.||.:|..|||.||:.||
Zfish   143 RHIVDNRVHCCFYFISPLGHGLKPLDVQFMKAIHNKVNVVPVIAKADTLTLRERERLKRRILDEI 207

  Fly   202 ESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENP 266
            :.||||||.|||.:||||||:|||.:.||.::||||.|:|..:|.||||||||||||||||||||
Zfish   208 DEHGIKIYHLPDAESDEDEDFKEQTRILKASIPFAVVGSNQQIEAKGKKVRGRLYPWGVVEVENP 272

  Fly   267 DHCDFIKLRTMLITHMQDLQEVTQEVHYENYRSDRLAKGIKGKENGV-----KAERDSSSQVVSN 326
            :|.||:||||||||||||||||||::||||:||:||.:|.:...:|.     .|:.....::
Zfish   273 EHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRLSSHGYILPLSPAKGPEPEEM--- 334

  Fly   327 SVLGEKDRILQEKEAELRRMQEMLAQMQARMQAQ 360
                :||.||.||||||||||||:|:|||:||.|
Zfish   335 ----DKDMILLEKEAELRRMQEMIAKMQAQMQKQ 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	236/333 (71%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	207/271 (76%)
sept2	NP_001288289.1	CDC3	19..>309	CDD:227352	225/289 (78%)
sept2	NP_001288289.1	Septin	38..310	CDD:279124	207/271 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	439	1.000	Domainoid score	I534
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3243
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1249
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		oto38921
orthoMCL	1	0.900	-	-		OOG6_107379
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.840