DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and Septin11

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001100678.1	Gene:	Septin11 / 305227	RGDID:	1307405	Length:	432	Species:	Rattus norvegicus

Alignment Length:	350	Identity:	151/350 - (43%)
Similarity:	218/350 - (62%)	Gaps:	32/350 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQ 73
            ::...|:|||.:||:|:..||..:||.|.::.|||:|:|||||:::||.|     :...|.....
  Rat    15 NLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNT-----KFESDPATHN 74

  Fly    74 KQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRR- 137
            :..|:|:|.:.|::|..|:|:||:|||.||||.|:..:|:..|:||||.|:|.:|::|..:.|.
  Rat    75 EPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSL 139

  Fly   138 -NIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEI 201
             |..|.|||.|.|||:|.||.||.||:..||||.|||||:|:|||||.:.|.|:.:.|.:||.|:
  Rat   140 FNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSEL 204

  Fly   202 ESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENP 266
            .|:|::||..|    .::|...|....:...:||||.|:...:::..|..:.|.||||||:|||.
  Rat   205 VSNGVQIYQFP----TDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENE 265

  Fly   267 DHCDFIKLRTMLI-THMQDLQEVTQEVHYENYRSDRLAKGIKGKENGVKAERDSSSQVVS----- 325
            :||||:|||.||| .:|:||:|.|...|||.||..:|      :|.|.| :.|..|:..|
  Rat   266 NHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKL------EEMGFK-DTDPDSKPFSLQETY 323

  Fly   326 ----NSVLGEKDRILQEKEAELRRM 346
                |..|||    ||:||.|:|:|
  Rat   324 EAKRNEFLGE----LQKKEEEMRQM 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	148/340 (44%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	125/274 (46%)
Septin11	NP_001100678.1	CDC_Septin	38..306	CDD:206649	126/282 (45%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	48..55		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	100..103		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	183..186		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750