DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and Septin7

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_033989.2	Gene:	Septin7 / 235072	MGIID:	1335094	Length:	437	Species:	Mus musculus

Alignment Length:	373	Identity:	204/373 - (54%)
Similarity:	264/373 - (70%)	Gaps:	34/373 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLY-PERIIPDAIEKQKQTV 77
            ||||||||||||:|||||:|||||||||||||||||||:||||||||| ||  .|....:.|:||
Mouse    29 GYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPE--YPGPSHRIKKTV 91

  Fly    78 KLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRRNIVDN 142
            ::|.|.|.|:|.||:|.||:|||||||||:||||.:..:::|||.::|.:|..||.:|||.:.||
Mouse    92 QVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDN 156

  Fly   143 RIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESHGIK 207
            |:.||.|||:|.||||||||:||||:||.||||:|:|||||.||.:|..:.|.:||:||:.|.||
Mouse   157 RVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIK 221

  Fly   208 IYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENPDHCDFI 272
            ||..|:.|   ||:..:.||::|:.:|.||.|:||::||.||:||||.|||||.||||.:||||.
Mouse   222 IYEFPETD---DEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFT 283

  Fly   273 KLRTMLI-THMQDLQEVTQEVHYENYRSDRLA----KGIKGKENGVKAERDSSSQV--------- 323
            .||.||| ||||||::||..||||||||.:||    .|:...:|..:..:...:|:
Mouse   284 ILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVA 348

  Fly   324 -----------VSNSVLGEKDRILQEKEAELRRMQEMLAQMQARMQAQ 360
                       |....:.||.:.|::.||||:|..|   ||:..::||
Mouse   349 KMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHE---QMKKNLEAQ 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	195/353 (55%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	170/277 (61%)
Septin7	NP_033989.2	CDC_Septin	47..317	CDD:206649	170/274 (62%)
		Interaction with SEPTIN12. /evidence=ECO:0000250\|UniProtKB:Q16181	47..317		170/274 (62%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	57..64		6/6 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	113..116		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	194..197		2/2 (100%)
		DUF3552	337..>433	CDD:330423	15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..437		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860