DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and Septin8

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001334425.1	Gene:	Septin8 / 20362	MGIID:	894310	Length:	484	Species:	Mus musculus

Alignment Length:	347	Identity:	153/347 - (44%)
Similarity:	216/347 - (62%)	Gaps:	26/347 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQ 73
            |:...|:|||.:||:|:..|||.:||.|.::.|||:|:|||||:|:||.|....|.     ....
Mouse    18 SLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNTTFETEE-----ASHH 77

  Fly    74 KQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRRN 138
            ::.|:|...|.:::|..|.|:||:||..||||.|:..:|:..|::|||.|:|.:|::|..: ||:
Mouse    78 EECVRLRPQTYDLQESNVHLKLTIVDAVGFGDQINKDDSYRPIVDYIDAQFENYLQEELKI-RRS 141

  Fly   139 IV---DNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQE 200
            :.   |.|||.|.|||:|.||.||.||:..||||.|||||:|:|||||.::|.|:.:.|.:||.|
Mouse   142 LFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGE 206

  Fly   201 IESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVEN 265
            :.|:|::||..|    .:||...|....:...:||||.|:...::|..|.||.|.||||||:|||
Mouse   207 LVSNGVQIYQFP----TDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVEN 267

  Fly   266 PDHCDFIKLRTMLI-THMQDLQEVTQEVHYENYRSDRLAKGIKGKENGVKAERDSSSQVVSNSVL 329
            .:||||:|||.||| .:|:||:|.|...|||.||..:|      :|.|.: :.|..||..|....
Mouse   268 ENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKL------EEMGFQ-DSDGDSQPFSLQET 325

  Fly   330 GEKDR-----ILQEKEAELRRM 346
            .|..|     .||.||.|:|:|
Mouse   326 YEAKRKEFLSELQRKEEEMRQM 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	149/337 (44%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	127/275 (46%)
Septin8	NP_001334425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		1/4 (25%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	51..58		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	103..106		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	186..189		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..429
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850