DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and Septin4

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	XP_006532556.1	Gene:	Septin4 / 18952	MGIID:	1270156	Length:	971	Species:	Mus musculus

Alignment Length:	359	Identity:	221/359 - (61%)
Similarity:	283/359 - (78%)	Gaps:	8/359 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEK 72
            ||.:...|||||.||||||||||||||:|||||.||||||||||||||||||||.:|.:..|.|:
Mouse   610 SSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEER 674

  Fly    73 QKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRR 137
            ..|||::....|:|||:||:||||:|||||||||::|:..:..:.||||:|:|::.||||||||:
Mouse   675 IMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRK 739

  Fly   138 NIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIE 202
            ||.|||:|||.||||||||||:||||||||.||.:|||||::||||.||..|:.|.||:|.:|||
Mouse   740 NIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIE 804

  Fly   203 SHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENPD 267
            ..|||||..||||||||||:|.|.:.|||::||||.|:||::|.:|::|||||||||:||||||.
Mouse   805 HFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPG 869

  Fly   268 HCDFIKLRTMLI-THMQDLQEVTQEVHYENYRS---DRLAKGIKGKENGVKAERDSSSQ----VV 324
            ||||:||||||: ||||||::||:|.||||||:   ..:.:.:..:.|..|..|:|.:.    .|
Mouse   870 HCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAV 934

  Fly   325 SNSVLGEKDRILQEKEAELRRMQEMLAQMQARMQ 358
            ......|.:::::||:.|||||||||.::|.:|:
Mouse   935 PPGTDPETEKLIREKDEELRRMQEMLHKIQRQMK 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	208/336 (62%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	184/275 (67%)
Septin4	XP_006532556.1	DUF4655	14..509	CDD:373934
Septin4	XP_006532556.1	Septin	634..914	CDD:366275	184/279 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860