DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and Septin2

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	XP_006529303.1	Gene:	Septin2 / 18000	MGIID:	97298	Length:	391	Species:	Mus musculus

Alignment Length:	354	Identity:	260/354 - (73%)
Similarity:	299/354 - (84%)	Gaps:	16/354 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FSSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIE 71
            |.:.|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||.|.|
Mouse    39 FINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERIIPGAAE 103

  Fly    72 KQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNR 136
            |.::||::|||||||||||||||||||||||:||||:..:.|..|:.|||||:||:|.|||||||
Mouse   104 KIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNR 168

  Fly   137 RNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEI 201
            |:|:|||:|||||||||||||||||||.|||.:|:||||||||||||.||.||..|||.||:.||
Mouse   169 RHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEI 233

  Fly   202 ESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENP 266
            |.|.||||.|||.:||||||:|||.:.||.::||:|.|:|.|:|.||||||||||||||||||||
Mouse   234 EEHSIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENP 298

  Fly   267 DHCDFIKLRTMLITHMQDLQEVTQEVHYENYRSDRLAKGIKGKENGVKAERDSSSQVVSNSVLGE 331
            :|.||:||||||||||||||||||::||||:||:||.:|      |.|.|.:..:
Mouse   299 EHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRG------GRKVENEDMN---------- 347

  Fly   332 KDRILQEKEAELRRMQEMLAQMQARMQAQ 360
            ||:||.||||||||||||:|:|||:||.|
Mouse   348 KDQILLEKEAELRRMQEMIARMQAQMQMQ 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	241/328 (73%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	211/271 (78%)
Septin2	XP_006529303.1	Septin	64..343	CDD:366275	214/284 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	439	1.000	Domainoid score	I551
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3243
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1267
Isobase	1	0.950	-	0	Normalized mean entropy	S763
OMA	1	1.010	-	-		QHG51878
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		oto92972
orthoMCL	1	0.900	-	-		OOG6_107379
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.810