DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and unc-59

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_493388.1	Gene:	unc-59 / 173233	WormBaseID:	WBGene00006793	Length:	459	Species:	Caenorhabditis elegans

Alignment Length:	386	Identity:	161/386 - (41%)
Similarity:	235/386 - (60%)	Gaps:	50/386 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQK- 74
            |.|.|.||||.||||.|::||.||:|||||||.|||||||.:|:|||.:      |.:..||:.
Worm    23 ENPNYWGFANFPNQVFRRAVKNGFDFTLMVVGRSGLGKSTFINTLFLAE------INNLNEKESA 81

  Fly    75 ------QTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESG 133
                  .||::|...|::.|..|.|.||:|||||||||::||..:..|:.|::.::.....:|:.
Worm    82 PTHPHPSTVRVEEKLVKLVENSVSLNLTLVDTPGFGDAVNNSKCWEPIVNYVESKFFEQFCEETR 146

  Fly   134 LNR-RNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRI 197
            ::| ..|||..:|.|.|||.|.||||||:|:|.||.||.:|||||||:||||||:.|:||.|.:|
Worm   147 IDRGEKIVDKCVHLCLYFIEPSGHGLKPIDIELMKHLHGRVNIVPVISKADCLTRDELLRFKKQI 211

  Fly   198 MQEIESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVE 262
            :::.|:..||:|..|:.:....:  |..:::|::|:|||:.|:|.|.|..|||:|.|.||||.||
Worm   212 VKDAETAEIKLYKFPELEDPYTD--KVAIEKLRKALPFAIIGSNMLKEKDGKKIRYREYPWGTVE 274

  Fly   263 VENPDHCDFIKLRTMLI-THMQDLQEVTQEVHYENYR---SDRLAKGIKG-------------KE 310
            |||..|.||:.||.|:| |::.|:.:||:.|||||:|   .:.|.|..|.             ||
Worm   275 VENMQHNDFLTLRDMIIRTNLIDMIDVTRNVHYENFRFRQMEGLPKNEKNRDPFTHLEEERRQKE 339

  Fly   311 NGVKAERDSSSQVVSNSVLGEKDR------ILQE-----------KEAELRRMQEMLAQMQ 354
            ..:..:|::..:|.:......|.|      .|:|           |.||:.|::..:::::
Worm   340 QDLDEKRNTLEKVFTEKTSARKKRSDERMSALEELEQQNKQKIDAKRAEIIRLRHEISELK 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	157/370 (42%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	133/283 (47%)
unc-59	NP_493388.1	CDC_Septin	44..318	CDD:206649	132/281 (47%)
unc-59	NP_493388.1	DUF4200	328..>401	CDD:372763	12/73 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I811
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S763
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm14281
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.810