DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sep1 and SEPTIN9

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001106963.1	Gene:	SEPTIN9 / 10801	HGNCID:	7323	Length:	586	Species:	Homo sapiens

Alignment Length:	337	Identity:	145/337 - (43%)
Similarity:	228/337 - (67%)	Gaps:	16/337 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADTKGFSSI-ETP-----------GYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVN 53
            ||||...:.: :.|           ||||..::..|:.||::|:||||.:||||:||||||||:|
Human   252 MADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLIN 316

  Fly    54 SLFLTDLYPERIIPDAIEKQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILE 118
            :||.:.:..:.:.|.:.|:..:|:::::.|.:|||:||:::|||:|||||||.|:|.|.:..|::
Human   317 TLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMK 381

  Fly   119 YIDEQYERFLRDESGLNR-RNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKA 182
            :|::|||::|::|..:|| :.|.|.|:|||.|||...||.|:|||:||||:|...||||||||||
Human   382 FINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKA 446

  Fly   183 DCLTKKEILRLKCRIMQEIESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVK 247
            |.||.:|.:..|.||..::.|:||.:||..:.|.|.::....:  :.:|.:||||.|::...:|.
Human   447 DTLTLEERVHFKQRITADLLSNGIDVYPQKEFDEDSEDRLVNE--KFREMIPFAVVGSDHEYQVN 509

  Fly   248 GKKVRGRLYPWGVVEVENPDHCDFIKLRTMLI-THMQDLQEVTQEVHYENYRSDRLAKGIKGKEN 311
            ||::.||...||.:||||..||:|..||.:|| ||||:::::|..:|:|.||..||.:|.....|
Human   510 GKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSSIHFEAYRVKRLNEGSSAMAN 574

  Fly   312 GVKAERDSSSQV 323
            |::.:...:.::
Human   575 GMEEKEPEAPEM 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	141/324 (44%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	129/273 (47%)
SEPTIN9	NP_001106963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..268		5/15 (33%)
		CDC3	277..583	CDD:227352	140/307 (46%)
		CDC_Septin	295..569	CDD:206649	129/275 (47%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	305..312		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	362..365		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	444..447		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850