DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep1 and septin2

DIOPT Version :9

Sequence 1:	NP_523430.1	Gene:	Sep1 / 33114	FlyBaseID:	FBgn0011710	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001090723.1	Gene:	septin2 / 100036706	XenbaseID:	XB-GENE-480201	Length:	355	Species:	Xenopus tropicalis

Alignment Length:	354	Identity:	256/354 - (72%)
Similarity:	300/354 - (84%)	Gaps:	15/354 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FSSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIE 71
            |::.||||||||||||||||||||:||||||||||||||||||||:||||||||||||::|.|.:
Frog     8 FTNPETPGYVGFANLPNQVHRKSVRKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVVPGAAD 72

  Fly    72 KQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNR 136
            |.::||::|||||||||||||||||||||||:|||::..:.|..|:.|:|.|:||:|.|||||||
Frog    73 KIERTVEIEASTVEIEERGVKLRLTVVDTPGYGDAMNCVDCFKPIISYVDNQFERYLHDESGLNR 137

  Fly   137 RNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEI 201
            |:|||||:|||||||||||||||||||||||.||:||||||||||||.||.:|..|||.|::.||
Frog   138 RHIVDNRVHCCFYFISPFGHGLKPLDVEFMKALHNKVNIVPVIAKADTLTLRERERLKRRVLDEI 202

  Fly   202 ESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENP 266
            |.||||||.|||.:||||||:|||.:.||.::||.|.|:|.|:|.||||||||||||||||||||
Frog   203 EEHGIKIYQLPDAESDEDEDFKEQTRLLKASIPFTVVGSNQLIEAKGKKVRGRLYPWGVVEVENP 267

  Fly   267 DHCDFIKLRTMLITHMQDLQEVTQEVHYENYRSDRLAKGIKGKENGVKAERDSSSQVVSNSVLGE 331
            :|.||:||||||||||||||||||::||||:||:||.||:..|...|:.               .
Frog   268 EHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKKGVASKVENVEV---------------T 317

  Fly   332 KDRILQEKEAELRRMQEMLAQMQARMQAQ 360
            ||:|||||||||||||||:|:|||:||.|
Frog   318 KDQILQEKEAELRRMQEMIARMQAQMQIQ 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep1	NP_523430.1	CDC3	13..342	CDD:227352	237/328 (72%)
Sep1	NP_523430.1	Septin	32..304	CDD:279124	207/271 (76%)
septin2	NP_001090723.1	Septin	33..313	CDD:366275	210/279 (75%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	43..50		6/6 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	100..103		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	181..184		2/2 (100%)
		Important for dimerization. /evidence=ECO:0000250	259..269		9/9 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I543
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3243
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1228
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm48164
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110