DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment peng and Pum3

DIOPT Version :9

Sequence 1:	NP_523429.1	Gene:	peng / 33112	FlyBaseID:	FBgn0015527	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001020207.1	Gene:	Pum3 / 499339	RGDID:	1564753	Length:	647	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	193/741 - (26%)
Similarity:	325/741 - (43%)	Gaps:	152/741 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ASPLKAHESSGKRANGQKFKPGGAGGARKFDKFGGGAGKSFVKPGAGGAKKFDKSGPGGFK---- 76
            |.|.||.:..|.:...:.|:.|.                  .|||....|:| |:.|.|.|
  Rat    34 AFPRKAAKEGGPKVTSKNFEKGA------------------TKPGKKRVKQF-KNKPQGGKGPKD 79

  Fly    77 KFDKSGATGDKRLGGNKFRGKPQTQPQAPAE---GEKQDWNKFKKEKKDLKLKRK-SAKDTYEIS 137
            ||.|:          |||..|.:.||...::   .:|..|:.|||:||:||..|: |.|..|::.
  Rat    80 KFQKA----------NKFNKKRKFQPDGKSDESAAKKPKWDDFKKKKKELKQNRQLSDKTNYDVV 134

  Fly   138 KEANQIHEKLR---CRRTENKDKLVEQIYKVLNVGDTISKVVKAHDTARVIQSMLKYASPALRAE 199
            ..|..|.|.||   |.: |.:.||:..:.|::.  ..|..:..|||:.||||.:::|.|...|..
  Rat   135 VRAKHIWESLRRKDCDK-EKRVKLMSDLQKLIQ--GKIKTIAFAHDSTRVIQCLIQYGSEEQRKW 196

  Fly   200 ISEKLLPFTVEMCQSKYAQFCVQRMLKYGAPATKAKLVDSLYGHIVRLAGHSIGSGLLDSMY-QS 263
            ..|:|....||:.::||::..|::.|.||:....|:::.|..||:.::..||..|.:::..| ..
  Rat   197 AFEELQGDLVELSKAKYSRNIVKKFLMYGSKPQIAEIIRSFKGHVRKMLRHSEASAIVEYAYNDK 261

  Fly   264 ATPNQRIYMRQEFYGDLYRKAKDSNVKTLSDTYKEATNMKASILGSVKANLDHVANKQ-LVDSAL 327
            |...||..:.:|.||:.::..|.::..||....:........||..:|..|..:|.|: ::..:|
  Rat   262 AILEQRNMLTEELYGNTFQLYKSADHPTLEKVLEVQPGKLELILDEMKQILTPMAQKEAVIKHSL 326

  Fly   328 VHAVMLEYLRACDEDEEKL-EETVTAFAALVPHMLSTKEGSEAAVICFYKSTPKNRRAIIKNIKE 391
            ||.|.|::....   ..|| .|.:.|....|.::..|.:|:..|:.|.:..|||:|:.|:|.:|.
  Rat   327 VHKVFLDFFTYA---PPKLRSELIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKT 388

  Fly   392 HLLKIANHEHGHVFLISLLNALDDTKATKKAIYDHLHGDLKALMSSPYGRRVIQWLVAPGDTTCF 456
            ::.||||.::.|:.|::..:.:||||..|:.|...:...|.::::..|||:|:.:|::|......
  Rat   389 YVEKIANGQYSHLVLLAAFDCIDDTKLVKQIIISEVISSLPSIVNDKYGRKVLLYLLSPRAPAHL 453

  Fly   457 HPEFIRTVE--EGLAFGKKEKELRRKEILEQIEAPIAQSIAEDAAFWLSNSHIGLVTGDILNHIQ 519
            .||.|:.::  :|.|..||:..:||:|:||.|...                        :|:::|
  Rat   454 VPEIIQLLQKGDGNAHSKKDTAIRRRELLESISPA------------------------LLSYLQ 494

  Fly   520 GESYEKAASALAQVVVQPEWRISADAAGPQPQDKKKPHNDVEAIIAQATKQRRKLLYVESSSDDE 584
            |.:.|........|:|..                         |:..||
  Rat   495 GHTREVVLDKSVCVLVSD-------------------------ILGSAT---------------- 518

  Fly   585 DEDEDEDEESDDEGDEKEQKEAAADDAEPKVKKAKKEPKKPKAKEEEPAAPLVSGIEEAGMHIVL 649
                         ||.:...:|.|..|..::....|:.:...|  |.||.           |:||
  Rat   519 -------------GDAQPAMDAIAGLAAEELYPGGKDGELHIA--EHPAG-----------HLVL 557

  Fly   650 KKILKNDGK-----REGTPFSQQLLQNLSSDVLKAWLGVNRACFVLLKLVEECPALLDDCKKAIA 709
            |.:::.|.|     :||. |::.|::.:....||:|..:||...||..|::.|..  |...|..|
  Rat   558 KWLIEQDKKIKENGKEGC-FAKTLVECVGMKNLKSWASINRGAIVLSSLLQSCDQ--DVVNKVKA 619

  Fly   710 AERSLSQILADRK--TPGAKLLAAKL 733
            ..::|...|...|  :.|.:.|..||
  Rat   620 GLKTLIPTLEKTKSTSKGIQTLLEKL 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
peng	NP_523429.1	Pumilio	<183..>254	CDD:277559	23/70 (33%)
peng	NP_523429.1	CPL	438..>537	CDD:285370	25/100 (25%)
Pum3	NP_001020207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..123		34/117 (29%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q15397	105..117		5/11 (45%)
		Pumilio 1. /evidence=ECO:0000250\|UniProtKB:Q15397	176..211		13/34 (38%)
		Pumilio	181..441	CDD:277559	76/262 (29%)
		Pumilio 2. /evidence=ECO:0000250\|UniProtKB:Q15397	212..247		10/34 (29%)
		Pumilio 3. /evidence=ECO:0000250\|UniProtKB:Q15397	248..276		7/27 (26%)
		Pumilio 4. /evidence=ECO:0000250\|UniProtKB:Q15397	288..324		8/35 (23%)
		Pumilio 5. /evidence=ECO:0000250\|UniProtKB:Q15397	325..360		10/37 (27%)
		Pumilio 6. /evidence=ECO:0000250\|UniProtKB:Q15397	361..396		13/34 (38%)
		Pumilio 7. /evidence=ECO:0000250\|UniProtKB:Q15397	397..434		9/36 (25%)
		CPL	433..570	CDD:285370	44/227 (19%)
		Pumilio 8. /evidence=ECO:0000250\|UniProtKB:Q15397	435..503		23/91 (25%)
		Pumilio 9. /evidence=ECO:0000250\|UniProtKB:Q15397	504..550		12/101 (12%)
		Pumilio 10. /evidence=ECO:0000250\|UniProtKB:Q15397	551..595		15/55 (27%)
		Pumilio 11. /evidence=ECO:0000250\|UniProtKB:Q15397	596..635		12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340861
Domainoid	1	1.000	174	1.000	Domainoid score	I3575
eggNOG	1	0.900	-	-		E1_KOG2050
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3546
OMA	1	1.010	-	-		QHG55991
OrthoDB	1	1.010	-	-		D503417at33208
OrthoFinder	1	1.000	-	-		FOG0004242
OrthoInspector	1	1.000	-	-		otm45580
orthoMCL	1	0.900	-	-		OOG6_102938
Panther	1	1.100	-	-	LDO	PTHR13389
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770