DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment peng and puf-12

DIOPT Version :9

Sequence 1:	NP_523429.1	Gene:	peng / 33112	FlyBaseID:	FBgn0015527	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_496178.1	Gene:	puf-12 / 174572	WormBaseID:	WBGene00014165	Length:	766	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	163/696 - (23%)
Similarity:	303/696 - (43%)	Gaps:	130/696 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AKKFDKSGPGGFKKFDKSGATGDKRLGGNKFR------GKPQTQPQAPAEGEKQDWNKFKKEK-- 120
            |:|...|.|..    |::..:.|::.||::..      .:.:...|.....::|..|..:||:
Worm   171 AEKAVASEPAD----DENLESVDEQAGGDESHIDIPTLKRKRVAIQVTKSVKEQLLNMPRKERKA 231

  Fly   121 --KDLKLKRK--SAKDTYEISKEANQIHEKLRCRRT--ENKDKLVEQIYKVLNVGDTISKVVKAH 179
              |:||||||  .|:     :::..::.||:|..:|  ..||..|.::|.:  |....:|::.||
Worm   232 FLKELKLKRKPEGAR-----AQKCKELWEKIRMGKTPKAEKDTAVHELYGL--VKGHAAKLIYAH 289

  Fly   180 DTARVIQSMLKYASPALRAEISEKLLPFTVEMCQSKYAQFCVQRMLKYGAPATKAKLVDSLYGHI 244
            ||:|||:.::......:...:..:|.|..|.|.::.|::|.|::|||.|....:..::::..||.
Worm   290 DTSRVIECLVATEREGIINNLFNELTPEIVRMSKNVYSKFFVKKMLKNGTKEQRDIIINAFRGHA 354

  Fly   245 VRLAGHSIGSGLLDSMYQS-ATPNQRIYMRQEFYGDLYRKAKDSNVKTLSDTYKEATNMKASILG 308
            ..|......:.:|:..|.. |..:||..:..||||..:...::.|:::|::...|....|..||.
Worm   355 PTLLRIKHAAEVLEYAYNDFANAHQRYNIITEFYGKEFILFREDNIRSLTEILAEKPEKKVVILK 419

  Fly   309 SVKANLDHVANKQLVDSALVHAVMLEYLRACDEDEEKLEETVTAFAALVPHMLSTKEGSEAAVIC 373
            .:...:..|..|:.:..:::|.:||::...|  ||||....:.:....:|..:.|.:|::.|:..
Worm   420 HLDEVIGAVNEKETLRLSILHKLMLDFFDNC--DEEKKINLLDSLKDKIPEFIHTPDGAKLAIKL 482

  Fly   374 FYKSTPKNRRAIIKNIKEHLLKIANHEHGHVFLISLLNALDDTKATKKAIYDHLHGDLKALMSSP 438
            .:.:..|.|:.|:||.|:..:|.|...:||..|::|.:.:|||....|.|...|..::|.|:...
Worm   483 IWFAPVKERKLIVKNFKDLSVKAAMEHYGHRVLLALFDTVDDTVLLNKVIVSELANEMKKLIEDD 547

  Fly   439 YGRRVIQWLVAPGDTTCFHPEFIRTVEEGLAFGKKEKELRRKEILEQIEAPIAQSIAEDAAFWLS 503
            :|.:||.:||.|.|........|..:.||.:....:|  .:|:...|:.|.|.:::
Worm   548 WGEKVIHYLVHPRDGRGIDKREITFLAEGDSNPHSKK--TQKDRYGQLYAGITENL--------- 601

  Fly   504 NSHIGLVTGDILNHIQGESYEKAASALAQVVVQPEWRISADAAGPQPQDKKKPHNDVEAIIAQAT 568
                               |...|:                              :.|.::.:|.
Worm   602 -------------------YPYLAA------------------------------NFEELVFEAN 617

  Fly   569 KQRRKLLYVESSSDDEDEDEDEDEESDDEGDEKEQKEAAADDAEPKVKKAKKEPKKPKAKEEEPA 633
            |.:.....:|::|            |.|..|.:...||.....:..|:.|||:           .
Worm   618 KSKFVAACLETTS------------SFDLFDRQVPAEARKSCNQAIVELAKKD-----------F 659

  Fly   634 APLVSGIEEAGMHI--------VLKKILKNDGK-REGTPFSQQLLQNLSSDVLKAWLGVNRACFV 689
            .|:    ::.|.||        :|..:::.|.. :|....|..|.:.|:|..|.:|:..||.|.|
Worm   660 VPM----DQEGFHIIEHQSGNFILMAVMRCDAALQEDERLSVALAEGLTSKQLGSWVTCNRGCHV 720

  Fly   690 LLKLVE-ECPALLDDCKKAIAAERSLSQILADRKTPGAKLLAAKLD 734
            |||::: ..|.:::..|.:|:.:.     |....:.||.||.|:||
Worm   721 LLKMLQVGGPKVIEKLKASISRKH-----LDGYNSKGANLLKAQLD 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
peng	NP_523429.1	Pumilio	<183..>254	CDD:277559	17/70 (24%)
peng	NP_523429.1	CPL	438..>537	CDD:285370	17/98 (17%)
puf-12	NP_496178.1	Pumilio	292..553	CDD:277559	67/262 (26%)
puf-12	NP_496178.1	CPL	545..692	CDD:285370	37/233 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159362
Domainoid	1	1.000	134	1.000	Domainoid score	I3104
eggNOG	1	0.900	-	-		E1_KOG2050
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I2573
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55991
OrthoDB	1	1.010	-	-		D503417at33208
OrthoFinder	1	1.000	-	-		FOG0004242
OrthoInspector	1	1.000	-	-		oto19322
orthoMCL	1	0.900	-	-		OOG6_102938
Panther	1	1.100	-	-	LDO	PTHR13389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1033
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.840