DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment peng and pum3

DIOPT Version :9

Sequence 1:	NP_523429.1	Gene:	peng / 33112	FlyBaseID:	FBgn0015527	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001116267.1	Gene:	pum3 / 100038289	XenbaseID:	XB-GENE-1001484	Length:	642	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	197/718 - (27%)
Similarity:	324/718 - (45%)	Gaps:	148/718 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TASP-LKAHESSGKRAN---GQKFKPGGAGGARKFDKFGGGAGKSFVKPGAGGAKKFDKSGPGGF 75
            |.|| .|..:.|.|:.|   ||  .|.|...:.||:|               ||||....|..|.
Frog    21 TDSPKFKKIKGSAKQHNKSTGQ--SPKGNAKSNKFEK---------------GAKKDRPGGKAGV 68

  Fly    76 KKFDKSGATGDKRLGGNKFRGKPQTQPQ-APAEGEKQDWNKFKKEKKDLK-LKRKSAKDTYEISK 138
            |:|   .|...|:.||...:.|.|.:.| ..:|.:|..|:.|||:||:|| .::::.||.|:|..
Frog    69 KQF---AAKNAKQGGGFTKKRKHQAEDQEGGSEAKKPKWDDFKKKKKELKQTRQQNDKDNYDIMA 130

  Fly   139 EANQIHEKLRCRRTENK--DKLVEQIYKVLNVGDTISKVVKAHDTARVIQSMLKYASPALRAEIS 201
            ::..|.|.:|.:..:.|  .||::.:.|||:  ..:..:..||||.||||..:|:.:...|.::.
Frog   131 KSKHIWETIRRKDCDGKKRSKLMDDLEKVLH--GNVKSIAFAHDTTRVIQCYIKHGNEERRQQVF 193

  Fly   202 EKLLPFTVEMCQSKYAQFCVQRMLKYGAPATKAKLVDSLYGHIVRLAGHSIGSGLLDSMY-QSAT 265
            |:|....|::.:||||:..|::.|.||:.|..|:::.|..|.:.:|..||..|.:::..| ..|.
Frog   194 EELKEHIVDLSKSKYARNIVRKFLMYGSKAQVAEIIKSFKGQVKKLLRHSEASYIVEYAYNHKAI 258

  Fly   266 PNQRIYMRQEFYGDLYRKAKDSNVKTLSDTYKEATNMKASILGSVKANLDHVANKQ-LVDSALVH 329
            ..||..:.:|.||:.:|..|.:...:|....:.....|.|||..:|..|..:..|: ::..:|||
Frog   259 LEQRNMLCEELYGNTFRFYKSAIHPSLDQVLEAQPEKKDSILDEMKQILVPLGQKEAVIKHSLVH 323

  Fly   330 AVMLEYLRACDEDEEKLEETVTAFAALVPHMLSTKEGSEAAVICFYKSTPKNRRAIIKNIKEHLL 394
            .|.|::.  .:...:...|.:.|....|.:::.|.:|:...:...:..|||:|:.|.|.:|.::.
Frog   324 KVYLDFF--SNASPKIRSEMIEAIREAVVYIIHTHDGARVGMHSVWHGTPKDRKVIAKTMKTYIE 386

  Fly   395 KIANHEHGHVFLISLLNALDDTKATKKAIYDHLHGDLKALMSSPYGRRVIQWLVAPGDTTCFHPE 459
            |||..|..|:.|:::.:.:||||..|:.|...|...|.::::..|||:|:.:|:...:...|.||
Frog   387 KIATGEFSHLVLLAMFDCVDDTKLLKQLILSELISSLPSIINDKYGRKVLLYLLNWRNPAHFVPE 451

  Fly   460 FIRTVEEG--LAFGKKEKELRRKEILEQIEAPIAQSIAE---DAAFWLSNSHIGLVTGDILNHIQ 519
            .:..:::|  .|..||:..:|:.|:||.|..|:.:.:.|   |..  |.|:..|:||..:|
Frog   452 IVEVLKKGDDNAHSKKDPTVRQHELLESISPPLLKYLEEHIQDVV--LQNALCGMVTSILL---- 510

  Fly   520 GESYEKAASALAQVVVQPEWRISADAAGPQPQDKKKPHNDVEAIIAQATKQRRKLLYVESSSDDE 584
                    .||..               |||.        :.||.:.|.::     :|
Frog   511 --------CALGD---------------PQPV--------MNAIASMAAEE-----FV------- 532

  Fly   585 DEDEDEDEESDDEGDEKEQKEAAADDAEPKVKKAKKEPKKPKAKEEEPAAPLVSGIEEAGMHIVL 649
                        .|.::.|...|                      |.||.           |:||
Frog   533 ------------PGGKEGQLHIA----------------------EHPAG-----------HLVL 552

  Fly   650 KKILKND------GKREGTPFSQQLLQNLSSDVLKAWLGVNRACFVLLKLVEECPALLDDCKKAI 708
            |.:||.|      || ||. |::.|:.::|.:.|..|..|||...||      | .||....:.|
Frog   553 KWLLKQDKDMKEKGK-EGC-FARTLVDHVSIEKLSQWAQVNRGAIVL------C-CLLQSSDEEI 608

  Fly   709 AAE 711
            ||:
Frog   609 AAQ 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
peng	NP_523429.1	Pumilio	<183..>254	CDD:277559	24/70 (34%)
peng	NP_523429.1	CPL	438..>537	CDD:285370	28/103 (27%)
pum3	NP_001116267.1	Pumilio	156..432	CDD:356422	80/279 (29%)
pum3	NP_001116267.1	CPL	428..565	CDD:369709	48/230 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3568
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3569
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D503417at33208
OrthoFinder	1	1.000	-	-		FOG0004242
OrthoInspector	1	1.000	-	-		oto104011
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1033
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.090