DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dod and PIN1

DIOPT Version :9

Sequence 1:	NP_523428.1	Gene:	dod / 33111	FlyBaseID:	FBgn0015379	Length:	166	Species:	Drosophila melanogaster
Sequence 2:	XP_011526370.1	Gene:	PIN1 / 5300	HGNCID:	8988	Length:	168	Species:	Homo sapiens

Alignment Length:	163	Identity:	83/163 - (50%)
Similarity:	99/163 - (60%)	Gaps:	14/163 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PDAEQLPDGWEKRTSRSTGMSYYLNMYTKESQWDQPTEPAKKAGGGSAGGGDAPDEVHCLHLLVK 66
            ||::..|           |..||.|..|..|||::|:  ...:.||..|.|: |..|.|.|||||
Human    18 PDSDLNP-----------GRVYYFNHITNASQWERPS--GNSSSGGKNGQGE-PARVRCSHLLVK 68

  Fly    67 HKGSRRPSSWREANITRTKEEAQLLLEVYRNKIVQQEATFDELARSYSDCSSAKRGGDLGKFGRG 131
            |..||||||||:..||||||||..|:..|..||...|..|:.||..:|||||||..||||.|.||
Human    69 HSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRG 133

  Fly   132 QMQAAFEDAAFKLNVNQLSGIVDSDSGLHIILR 164
            |||..||||:|.|...::||.|.:|||:|||||
Human   134 QMQKPFEDASFALRTGEMSGPVFTDSGIHIILR 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dod	NP_523428.1	WW	7..39	CDD:197736	10/31 (32%)
dod	NP_523428.1	PTZ00356	55..166	CDD:185573	67/110 (61%)
PIN1	XP_011526370.1	WW	<25..42	CDD:278809	8/16 (50%)
		Rotamase_2	56..167	CDD:298667	67/112 (60%)
		SurA	<58..164	CDD:223831	62/105 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158846
Domainoid	1	1.000	126	1.000	Domainoid score	I5476
eggNOG	1	0.900	-	-		E1_COG0760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4531
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4028
Isobase	1	0.950	-	0	Normalized mean entropy	S623
OMA	1	1.010	-	-		QHG56539
OrthoDB	1	1.010	-	-		D1437969at2759
OrthoFinder	1	1.000	-	-		FOG0001686
OrthoInspector	1	1.000	-	-		oto89289
orthoMCL	1	0.900	-	-		OOG6_100390
Panther	1	1.100	-	-	LDO	PTHR10657
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R926
SonicParanoid	1	1.000	-	-		X2519
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750