DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and VLN4

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001190869.1	Gene:	VLN4 / 829139	AraportID:	AT4G30160	Length:	983	Species:	Arabidopsis thaliana

Alignment Length:	806	Identity:	221/806 - (27%)
Similarity:	346/806 - (42%)	Gaps:	135/806 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRAC 558
            ||..|:.||.||||:|..|.:...|||:.||.||||||.....|.|..:|.:|:|.:.:.|:...
plant    16 GQKAGIEIWRIENFIPTPIPKSSIGKFFTGDSYIVLKTTALKTGALRHDIHYWLGKDTSQDEAGT 80

  Fly   559 AAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLV 623
            ||:..|.|...||.|....||.||.|:|:|||.|:..:|..||| .|:||..:....|||||::.
plant    81 AAVKTVELDAALGGRAVQYREVQGHETEKFLSYFKPCIIPQEGG-VASGFKHVVAEEHITRLFVC 144

  Fly   624 HAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKC 688
            .. ...:|::.|..|.:||:....::||..:.|:.:.|..|.....:||..:.:.|..|.....|
plant   145 RG-KHVVHVKEVPFARSSLNHDDIYILDTKSKIFQFNGSNSSIQERAKALEVVQYIKDTYHDGTC 208

  Fly   689 EIQLERQGE-----ESAEFWQGLGMTSEEADAAEPPKEHVPED--YQPVQPRLYQVQLGMGYLEL 746
            |:.....|:     :|.|||...|     ..|..|.|....||  |.....||:.|:.|    :.
plant   209 EVATVEDGKLMADADSGEFWGFFG-----GFAPLPRKTANDEDKTYNSDITRLFCVEKG----QA 264

  Fly   747 PQVELPEQKLCHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVM 811
            ..||  ...|...:|::...|||||..::|||.|:.::...|..|.|.:.|:....:||...::
plant   265 NPVE--GDTLKREMLDTNKCYILDCGIEVFVWMGRTTSLDDRKIASKAAEEMIRSSERPKSQMI- 326

  Fly   812 RVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQ---- 872
            |:.||.|...||:||..|.:       .|..:|::.|            |..:||| :.||
plant   327 RIIEGFETVPFRSKFESWTQ-------ETNTTVSEDG------------RGRVAAL-LQRQGVNV 371

  Fly   873 ----SAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEE 933
                .|.|..|..|:..:...:|::..   :..:....|...:..:||:|:||||  :|..|.||
plant   372 RGLMKAAPPKEEPQVFIDCTGNLQVWR---VNGQAKTLLQAADHSKFYSGDCYVF--QYSYPGEE 431

  Fly   934 PENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNA-----GNMGWLTFTFTLQKKFKAMF 993
            .|                          :.::..|.|:.:     |:...:........||..
plant   432 KE--------------------------EVLIGTWFGKQSVEEERGSAVSMASKMVESMKFVP-- 468

  Fly   994 GEELEVVRIFQQQENLKFMSHFKRKFIIHTG----------KRKDKAHTAKGKSPVEFFHLRSNG 1048
                ...||::.:|.::|.. ..:.||:..|          ..|:.......::.|..|.::.:|
plant   469 ----AQARIYEGKEPIQFFV-IMQSFIVFKGGISSGYKKYIAEKEVDDDTYNENGVALFRIQGSG 528

  Fly  1049 GALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFN 1113
            .. ..:.||::|.|..|||::.||||      :||.   |:.|.|    |......|::||:..:
plant   529 PE-NMQAIQVDPVAASLNSSYYYILH------NDSS---VFTWAG----NLSTATDQELAERQLD 579

  Fly  1114 --SPWVSLQILNEGDEPENFFWVALGGRKPYDTD---AEYMNYTRLFRCSNERGYYTV------- 1166
              .|....:...||.|.|. ||..|||:..|.:.   .|......||.|:..:....|
plant   580 LIKPNQQSRAQKEGSESEQ-FWELLGGKAEYSSQKLTKEPERDPHLFSCTFTKEVLKVRILLKSF 643

  Fly  1167 -AEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQ---PERP 1227
             ..:..:|.||||..:||.|:|....:|:|:|.........||....:.:|:...:.:   ||.|
plant   644 FVTEIYNFTQDDLMTEDIFIIDCHSEIFVWVGQEVVPKNKLLALTIGEKFIEKDSLLEKLSPEAP 708

  Fly  1228 RKLFLTMKNKESRRFTKCFHGWSAFK 1253
              :::.|:..|...||:.|..|.:.|
plant   709 --IYVIMEGGEPSFFTRFFTSWDSSK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	47/107 (44%)
		gelsolin_like	618..706	CDD:200436	24/92 (26%)
		gelsolin_S3_like	729..828	CDD:200448	31/98 (32%)
		gelsolin_like	920..1015	CDD:200436	18/99 (18%)
		gelsolin_S5_like	1037..1141	CDD:200444	33/105 (31%)
		gelsolin_S6_like	1151..1250	CDD:200447	27/109 (25%)
VLN4	NP_001190869.1	gelsolin_S1_like	12..124	CDD:200446	47/107 (44%)
		gelsolin_S2_like	139..217	CDD:200445	19/78 (24%)
		gelsolin_S3_like	253..343	CDD:200448	31/96 (32%)
		gelsolin_S4_like	386..486	CDD:200449	23/137 (17%)
		gelsolin_S5_like	517..608	CDD:200444	33/105 (31%)
		gelsolin_S6_like	621..729	CDD:200447	27/109 (25%)
		VHP	949..983	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I4429
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880