DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and GHR1

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001320016.1	Gene:	GHR1 / 827842	AraportID:	AT4G20940	Length:	1037	Species:	Arabidopsis thaliana

Alignment Length:	548	Identity:	156/548 - (28%)
Similarity:	233/548 - (42%)	Gaps:	142/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VDFTKNDFSATFPSSMRQMSRVQWLTL-DRTQLAEIPEELGHLQKLEHLSLNHNRLEKIFGELTE 73
            :..:.|..|...|:.:.....:|:|.| |....:.:|:|:|....|.:|||:.|...   ||:.|
plant    83 LSMSNNSLSGVLPNDLGSFKSLQFLDLSDNLFSSSLPKEIGRSVSLRNLSLSGNNFS---GEIPE 144

  Fly    74 ----LSCLRSLDLRHNQLKNSG-IPPELFHLEELTTLDLSHNKLK-EVPEGLERAKNLIVLNLSN 132
                |..|:|||:..|.|  || :|..|..|.:|..|:||.|... ::|.|.|...:|.||:|..
plant   145 SMGGLISLQSLDMSSNSL--SGPLPKSLTRLNDLLYLNLSSNGFTGKMPRGFELISSLEVLDLHG 207

  Fly   133 NQIESIPTPLFIHLTDLLFLDLSHNRLET-----LPPQTRRLINLKTLDLSHNPLE--------L 184
            |.|:......|..||:..::|:|.|||.|     ||..:.   ::|.|:||||.||        |
plant   208 NSIDGNLDGEFFLLTNASYVDISGNRLVTTSGKLLPGVSE---SIKHLNLSHNQLEGSLTSGFQL 269

  Fly   185 FQ-LR-----------QLPS---LQSLEVLKMSGTQRTLLNFPTSI---DSLANLCELDLSHNSL 231
            || |:           :||.   :..|||||:| ..|...:.|.::   |||. |..||||.|:|
plant   270 FQNLKVLDLSYNMLSGELPGFNYVYDLEVLKLS-NNRFSGSLPNNLLKGDSLL-LTTLDLSGNNL 332

  Fly   232 PKLPDCVYNVVTLVRLNLSDNELTE----LTAGVEL-----------------WQRLESLNLSRN 275
            ......:.: .||..|:||.|.||.    ||.|..|                 |:.:|.|:||:|
plant   333 SGPVSSIMS-TTLHTLDLSSNSLTGELPLLTGGCVLLDLSNNQFEGNLTRWSKWENIEYLDLSQN 396

  Fly   276 QLV-ALPAALCKL-------------------------PKLRRLLVNDNKLNFEG-IPSGIGKLG 313
            ... :.|.|..:|                         ||||.|.::.|.|  || ||..:..:.
plant   397 HFTGSFPDATPQLLRANHLNLSYNKLTGSLPERIPTHYPKLRVLDISSNSL--EGPIPGALLSMP 459

  Fly   314 ALEVFSAANN-----------------LLEM--------VPEGLCRCGALKQLNLSCNRLI-TLP 352
            .||.....||                 ||::        :|........|:.|||:.|.|. :||
plant   460 TLEEIHLQNNGMTGNIGPLPSSGSRIRLLDLSHNRFDGDLPGVFGSLTNLQVLNLAANNLSGSLP 524

  Fly   353 DAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYNIDFSLQTQLRLAGAAVPPSM----PS 413
            .:::.:..|..||:..|.  ...|.||..|  :::..:|:.::     .|:| .||.::    |.
plant   525 SSMNDIVSLSSLDVSQNH--FTGPLPSNLS--SNIMAFNVSYN-----DLSG-TVPENLKNFPPP 579

  Fly   414 SATPKDSTARKIRLRRGPRSEGDQDAAK 441
            |..|.:|   |:.|..|.......:|:|
plant   580 SFYPGNS---KLVLPAGSPGSSASEASK 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	3/19 (16%)
		leucine-rich repeat	31..53	CDD:275380	7/22 (32%)
		LRR_8	53..112	CDD:290566	25/63 (40%)
		leucine-rich repeat	54..76	CDD:275380	9/25 (36%)
		LRR_RI	70..304	CDD:238064	99/317 (31%)
		leucine-rich repeat	77..101	CDD:275380	11/24 (46%)
		LRR_8	101..159	CDD:290566	20/58 (34%)
		leucine-rich repeat	102..124	CDD:275380	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		leucine-rich repeat	149..171	CDD:275380	8/26 (31%)
		LRR_8	152..231	CDD:290566	39/109 (36%)
		leucine-rich repeat	172..195	CDD:275380	14/45 (31%)
		leucine-rich repeat	196..220	CDD:275380	11/26 (42%)
		leucine-rich repeat	221..243	CDD:275380	7/21 (33%)
		LRR_8	243..300	CDD:290566	27/103 (26%)
		leucine-rich repeat	244..266	CDD:275380	12/42 (29%)
		leucine-rich repeat	267..289	CDD:275380	8/47 (17%)
		leucine-rich repeat	290..314	CDD:275380	9/24 (38%)
		LRR_8	315..370	CDD:290566	18/80 (23%)
		leucine-rich repeat	315..335	CDD:275380	7/44 (16%)
		leucine-rich repeat	338..360	CDD:275378	8/22 (36%)
		gelsolin_S1_like	491..602	CDD:200446
		gelsolin_like	618..706	CDD:200436
		gelsolin_S3_like	729..828	CDD:200448
		gelsolin_like	920..1015	CDD:200436
		gelsolin_S5_like	1037..1141	CDD:200444
		gelsolin_S6_like	1151..1250	CDD:200447
GHR1	NP_001320016.1	PLN00113	2..1036	CDD:215061	156/548 (28%)
		leucine-rich repeat	80..103	CDD:275380	3/19 (16%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..151	CDD:275380	9/25 (36%)
		leucine-rich repeat	152..175	CDD:275380	11/24 (46%)
		leucine-rich repeat	176..199	CDD:275380	8/22 (36%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		leucine-rich repeat	224..248	CDD:275380	8/26 (31%)
		leucine-rich repeat	249..272	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..314	CDD:275380	8/18 (44%)
		leucine-rich repeat	344..387	CDD:275380	12/42 (29%)
		leucine-rich repeat	388..412	CDD:275380	8/23 (35%)
		leucine-rich repeat	413..436	CDD:275380	0/22 (0%)
		leucine-rich repeat	437..460	CDD:275380	9/24 (38%)
		leucine-rich repeat	461..484	CDD:275380	4/22 (18%)
		leucine-rich repeat	485..508	CDD:275380	3/22 (14%)
		leucine-rich repeat	509..532	CDD:275380	8/22 (36%)
		leucine-rich repeat	533..553	CDD:275380	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910