DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and VLN2

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001323674.1	Gene:	VLN2 / 818773	AraportID:	AT2G41740	Length:	976	Species:	Arabidopsis thaliana

Alignment Length:	795	Identity:	219/795 - (27%)
Similarity:	356/795 - (44%)	Gaps:	122/795 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRAC 558
            ||.||..||.||||....:.:..|||||.||.||||:|..:..|...::|.||||.:.:.|:...
plant    14 GQKPGTEIWRIENFEAVPVPKSEHGKFYMGDTYIVLQTTQNKGGAYLFDIHFWIGKDTSQDEAGT 78

  Fly   559 AAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLV 623
            ||:..|.|...||.|....||.||.||::|||.|:..:|.:||| .|:||.|:||.:..||||..
plant    79 AAVKTVELDAVLGGRAVQHREIQGHESDKFLSYFKPCIIPLEGG-VASGFKTVEEEVFETRLYTC 142

  Fly   624 HAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKC 688
            ....| |.|:.|..|.:||:....|:||....||.:.|..|.....:||..:.:.:.....:..|
plant   143 KGKRA-IRLKQVPFARSSLNHDDVFILDTEEKIYQFNGANSNIQERAKALEVVQYLKDKYHEGTC 206

  Fly   689 EIQLERQGE-----ESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYLELPQ 748
            ::.:...|:     :|..||...|..:..........:.|||.   ..|:||.:..|       :
plant   207 DVAIVDDGKLDTESDSGAFWVLFGGFAPIGRKVANDDDIVPES---TPPKLYCITDG-------K 261

  Fly   749 VELPEQKLCHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRV 813
            :|..:..|..::|.:...|:|||..::::|.|:.:....|.||.:.:.|.....:||....|.||
plant   262 MEPIDGDLSKSMLENTKCYLLDCGAEIYIWVGRVTQVDERKAASQSAEEFLASENRPKATHVTRV 326

  Fly   814 PEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQSAMPL- 877
            .:|.|...|::.|..|            .|.:.|..|       :|.|..:|||.  :|..:.|
plant   327 IQGYESHSFKSNFDSW------------PSGSATPGN-------EEGRGKVAALL--KQQGVGLK 370

  Fly   878 --AEAEQLEEEWNYDLE---MMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENG 937
              |::..:.|:....||   .:|.:.:..|....||:|::|:.|:|:||:.|..|
plant   371 GIAKSAPVNEDIPPLLESGGKLEVWYVNGKVKTPLPKEDIGKLYSGDCYLVLYTY---------- 425

  Fly   938 SEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNA-----GNMGWLTFTFTLQKKFKAMFGEEL 997
                         .|...:.|..:.|    |.|:.:     .....|..|.:...|.:.:.|
plant   426 -------------HSGERKDEYFLSC----WFGKKSIPEDQDTAIRLANTMSNSLKGRPVQG--- 470

  Fly   998 EVVRIFQQQENLKFMSHFKRKFIIHTG------------KRKDKAHTAKGKSPVEFFHLRSNGGA 1050
               ||::.:|..:|::.|:...::..|            :..|:.:|.:..:.|:.    |..|.
plant   471 ---RIYEGKEPPQFVALFQPMVVLKGGLSSGYKSSMGESESTDETYTPESIALVQV----SGTGV 528

  Fly  1051 LTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGI-VYVWIGSKACNEEAKLVQDIAEQMFNS 1114
            ...:.:|:...|..|||..|::|          |||. :::|.|:::.:|:.:|...:||  |..
plant   529 HNNKAVQVETVATSLNSYECFLL----------QSGTSMFLWHGNQSTHEQLELATKVAE--FLK 581

  Fly  1115 PWVSLQILNEGDEPENFFWVALGGRKPYDT---DAEYMNYTRLFRCSNERGYYTVAEKCADFCQD 1176
            |.::|:...||.| .:.||.||||::.:.:   .:|.:....||..:..||.:.| |:..:|.||
plant   582 PGITLKHAKEGTE-SSTFWFALGGKQNFTSKKASSETIRDPHLFSFAFNRGKFQV-EEIYNFAQD 644

  Fly  1177 DLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQ---HMRIKQPERPRKLFLTMKNKE 1238
            ||..:||..||....||:|:|......|.:..::..|.||.   .:....|:.|  ::...:..|
plant   645 DLLTEDIYFLDTHAEVFVWVGQCVEPKEKQTVFEIGQKYIDLAGSLEGLHPKVP--IYKINEGNE 707

  Fly  1239 SRRFTKCFHGWSAFK 1253
            ...||..| .|.|.|
plant   708 PCFFTTYF-SWDATK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	48/107 (45%)
		gelsolin_like	618..706	CDD:200436	25/92 (27%)
		gelsolin_S3_like	729..828	CDD:200448	26/98 (27%)
		gelsolin_like	920..1015	CDD:200436	17/99 (17%)
		gelsolin_S5_like	1037..1141	CDD:200444	31/104 (30%)
		gelsolin_S6_like	1151..1250	CDD:200447	29/101 (29%)
VLN2	NP_001323674.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880