DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and VLN1

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001189635.1	Gene:	VLN1 / 817539	AraportID:	AT2G29890	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	816	Identity:	186/816 - (22%)
Similarity:	327/816 - (40%)	Gaps:	174/816 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRAC 558
            |...||.||.:.|.....|.:...|||:.|:.|:||:|....:....::|.:|:|.:|.......
plant    16 GTKSGLEIWCVYNKQLISIPKSSFGKFHSGNAYLVLRTFLRKIESPQYDIHYWLGIDANEVDSIL 80

  Fly   559 AAIHAVNLRNFLGARCRTV--REEQGDESEQFLSLFETEVIYIEGGRT-ATGFYTIEEMIHITRL 620
            |:..|::|...||  |.||  ||.||.|:|:|||.|:..:|.:||..: .||.  ..|...:|
plant    81 ASDKALDLDAALG--CCTVQYREVQGQETEKFLSYFKPCIIPVEGKYSPKTGI--AGETYQVT-- 139

  Fly   621 YLVHAYG-ATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTER 684
             |:...| ..:.::.|....:||:....|:||..:.::::.|..|.....:||..:.|.|...:.
plant   140 -LLRCKGDHVVRVKEVPFLRSSLNHDDVFILDTASKVFLFAGCNSSTQEKAKAMEVVEYIKDNKH 203

  Fly   685 KNKCEIQLERQGE-----ESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRL----YQVQLG 740
            ..:||:.....|:     ::.|||...|                  .|.|: |:|    .|.|..
plant   204 DGRCEVATIEDGKFSGDSDAGEFWSFFG------------------GYAPI-PKLSSSTTQEQTQ 249

  Fly   741 MGYLELPQVELP-------EQKLCHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSREL 798
            ....||..::..       ...|...:|.....|:|||::::|||.|:.::...|..::..|.|.
plant   250 TPCAELFWIDTKGNLHPTGTSSLDKDMLEKNKCYMLDCHSEVFVWMGRNTSLTERKTSISSSEEF 314

  Fly   799 FNMMDRPDYALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTD 863
            .....|.....::.:.||.|...||:.|..|.:        |.:|           :...|.|..
plant   315 LRKEGRSTTTSLVLLTEGLENARFRSFFNKWPQ--------TVES-----------SLYNEGREK 360

  Fly   864 LAALFMPRQSAMPLAEAEQLEEE------------WNYDLEMMEAFVLENKKFVRLPEEELGRFY 916
            :||||  :|....:.|....|::            |..|        .::...:.:|::.  :.:
plant   361 VAALF--KQKGYDVEELPDEEDDPLYTNCRDNLKVWRVD--------GDDVSLLSIPDQT--KLF 413

  Fly   917 TGECYVFLCRYCIPIEEPEN------GSEDGANPAAD-VSKSSA--NNQPEDEIQCVVYFWQGRN 972
            ||:||:...:|... |..|:      |.|......|| ::.:||  .....:.:.|.:|  ||..
plant   414 TGDCYLVQYKYTYK-ERTEHLLYVWIGCESIQQDRADAITNASAIVGTTKGESVLCHIY--QGNE 475

  Fly   973 AGN-----MGWLTFTFTLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHT 1032
            ...     ...:.|...|.:::|.:..|:.::...:.:.:...|.       ::.|..|..:|
plant   476 PSRFFPMFQSLVVFKGGLSRRYKVLLAEKEKIGEEYNENKASLFR-------VVGTSPRNMQA-- 531

  Fly  1033 AKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGI-VYVWIGSKA 1096
                                   ||:|..|..|||::.|||          |.|. .:.|||..:
plant   532 -----------------------IQVNLVATSLNSSYSYIL----------QYGASAFTWIGKLS 563

  Fly  1097 CNEEAKLVQDIAEQMFNSPWVSLQ--ILNEGDEPENFFWVALGGRKPYDTDAE---YMNYTRLFR 1156
            .:.:    .::.::|......|.|  .:.||:|.:. ||..|||:..|..:.|   .:....||.
plant   564 SDSD----HEVLDRMLYFLDTSCQPIYIREGNETDT-FWNLLGGKSEYPKEKEMRKQIEEPHLFT 623

  Fly  1157 CSNERGYYTV-AEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVK-------LAYKSAQ 1213
            ||...|...: .::..:|.||||..:|:.:||....|::|:|.. |.::.|       |.:....
plant   624 CSCSSGNDVLKVKEIYNFVQDDLTTEDVFLLDCQSEVYVWIGSN-SNIKSKEEALTLGLKFLEMD 687

  Fly  1214 VYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGW 1249
            :..:.:.::.|     :::..:..|...||:.|. |
plant   688 ILEEGLTMRTP-----VYVVTEGHEPPFFTRFFE-W 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	39/109 (36%)
		gelsolin_like	618..706	CDD:200436	21/93 (23%)
		gelsolin_S3_like	729..828	CDD:200448	27/109 (25%)
		gelsolin_like	920..1015	CDD:200436	20/108 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	26/106 (25%)
		gelsolin_S6_like	1151..1250	CDD:200447	25/107 (23%)
VLN1	NP_001189635.1	gelsolin_S1_like	12..123	CDD:200446	38/108 (35%)
		gelsolin_S2_like	140..231	CDD:200445	20/90 (22%)
		gelsolin_S3_like	245..344	CDD:200448	24/98 (24%)
		gelsolin_S4_like	383..483	CDD:200449	20/112 (18%)
		gelsolin_S5_like	514..605	CDD:200444	30/137 (22%)
		gelsolin_S6_like	618..717	CDD:200447	24/105 (23%)
		VHP	898..933	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I4429
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880