DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Avil

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_038935869.1	Gene:	Avil / 79253	RGDID:	620301	Length:	848	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	232/838 - (27%)
Similarity:	358/838 - (42%)	Gaps:	179/838 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 PGLTIWEIENFLPNKIEEVV-----HGKFYEGDCYIVLKTKFDDLG-LLDWEIFFWIGNEATLDK 555
            ||:..|.||     |:|.|:     ||.||||||||:|.|:  .:| ||...|.||||.:::.|:
  Rat    14 PGIITWRIE-----KMELVLVPLSAHGNFYEGDCYIILSTR--RVGSLLSQNIHFWIGKDSSQDE 71

  Fly   556 RACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGG------RTATGFYTIEEM 614
            ::||||:...|.::||......||.|..||:.|...|:..:||.:||      ...|..|.::.:
  Rat    72 QSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKRGIIYKKGGVASGMKHVETNTYDVKRL 136

  Fly   615 IHI--------TRLYLVHAYGATIHLE-PVAPAITSL-------------DPRHAFVLDLGTHIY 657
            :|:        |.:...|.....:.|. |:.|..|:|             :....|:||||..|.
  Rat   137 LHVKGKRNIRATEVSPTHDCLGPVFLPWPLRPPQTALASPMQVEMSWDSFNQGDVFLLDLGMVII 201

  Fly   658 IWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPP--- 719
            .|.|..|.:....||.|:|:.|...||..:.||                |:...:.:||.|.
  Rat   202 QWNGPESNSGERLKAMLLAKDIRDRERGGRAEI----------------GVIEGDKEAASPELMT 250

  Fly   720 ------------KEHVPEDYQPVQPR----LYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYI 768
                        |..||::....|.:    ||.|....|.|.:  .|:..:.|...|||....||
  Rat   251 VLQNTLGRRSIIKPAVPDEVTDQQQKSTIMLYHVSDTTGQLSV--TEVATRPLVQELLNHDDCYI 313

  Fly   769 LD-CYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGW--- 829
            || ..|.::||.||.:|::.:.||:..:.:...|...|....|..|.:|.|..:|:..|..|
  Rat   314 LDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVK 378

  Fly   830 DEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNYDLEMM 894
            |:...:..|.:...:||.          .:.:.|:..|    .:...:|..|::.::.|..:|:.
  Rat   379 DQTTGLGKTFSIGKIAKI----------FQDKFDVTLL----HTKPEVAAQERMVDDGNGKVEVW 429

  Fly   895 EAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPED 959
            .   :||.:.|.:..:..|.||.|:||:.|..|                   ||     |.:|
  Rat   430 R---IENLELVPVEYQWHGFFYGGDCYLVLYTY-------------------DV-----NGKP-- 465

  Fly   960 EIQC-VVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEV----------VRIFQQQENLKFMS 1013
               | ::|.||||:|.           |.:..|...:.:||          ||:...:|...||:
  Rat   466 ---CYILYIWQGRHAS-----------QDELAASAYQAVEVDQQFGGAPVQVRVSMGKEPRHFMA 516

  Fly  1014 HFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFE 1078
            .||.|.:|:.|....|.: .:...||..|.:..|..: .|:.::::..|..|||...::|....|
  Rat   517 IFKGKLVIYEGGTSRKGN-VEPDPPVRLFQIHGNDKS-NTKAVEVSASASSLNSNDVFLLWTQAE 579

  Fly  1079 TEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYD 1143
            .         |:|.|..:..:|..:.:::||.:.:.   ....:.||.||.. ||..|||:.||.
  Rat   580 H---------YLWYGKGSSGDERAMAKELAELLCDG---DADTVAEGQEPPE-FWDLLGGKAPYA 631

  Fly  1144 TDAEYMNYT-----RLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEV 1203
            .|......|     |||.|||:.|.:.|.| ..||.||||:..|:|:||..:.||||:|...:..
  Rat   632 NDKRLQQETLDIQVRLFECSNKTGRFLVTE-VTDFTQDDLSPGDVMLLDTWDQVFLWIGAEANAT 695

  Fly  1204 EVKLAYKSAQVY-IQHMRIKQPERPRKLFLTMKNKESRRFTKCF-----HGWSAFKVY 1255
            |.:.|..:||.| :.|...:.|:.|  :.:..:..|...||..|     |.||..|.|
  Rat   696 EKEGALSTAQEYLVTHPSGRDPDTP--ILIIKQGFEPPTFTGWFLAWDPHIWSEGKSY 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	45/110 (41%)
		gelsolin_like	618..706	CDD:200436	25/101 (25%)
		gelsolin_S3_like	729..828	CDD:200448	31/103 (30%)
		gelsolin_like	920..1015	CDD:200436	24/105 (23%)
		gelsolin_S5_like	1037..1141	CDD:200444	26/103 (25%)
		gelsolin_S6_like	1151..1250	CDD:200447	38/109 (35%)
Avil	XP_038935869.1	gelsolin_S1_like	7..118	CDD:200446	45/110 (41%)
		gelsolin_S2_like	133..252	CDD:200445	30/134 (22%)
		gelsolin_S3_like	276..374	CDD:200448	30/99 (30%)
		gelsolin_S4_like	418..518	CDD:200449	33/142 (23%)
		gelsolin_S5_like	539..629	CDD:200444	26/103 (25%)
		gelsolin_S6_like	646..741	CDD:200447	36/97 (37%)
		VHP	813..847	CDD:396679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820