DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and SVIL

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_024303906.1	Gene:	SVIL / 6840	HGNCID:	11480	Length:	2334	Species:	Homo sapiens

Alignment Length:	1521	Identity:	321/1521 - (21%)
Similarity:	534/1521 - (35%)	Gaps:	534/1521 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 NKLKEVPE-------GLERAKNLIVLN-LSNNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQT 166
            |:.||:.|       .|..|:.|.:.| ||....::|.|               .||::|    .
Human   875 NEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAIST---------------RNRIDT----R 920

  Fly   167 RRLINLKTLDLSHNPLELFQLRQLPSLQSLEVLKMSGTQRTLLNFPTSIDSLANLCELD------ 225
            :|.:|.:   ....|:.|.::.|   :||.:::..|....|.::  |...::|.:...|
Human   921 QRRMNAR---YQTQPVTLGEVEQ---VQSGKLIPFSPAVNTSVS--TVASTVAPMYAGDLRTKPP 977

  Fly   226 LSHNSLP---KLPDCVYNVVTLVRLNLSDNELTELTAGVELWQRLESLNLSRNQLVALPAALCKL 287
            |.||:..   |....:.|..:.||..|..          :.||.|  :..|.|:
Human   978 LDHNASATDYKFSSSIENSDSPVRSILKS----------QAWQPL--VEGSENK----------- 1019

  Fly   288 PKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLEMVPEG---------LCRCGALKQLNL 343
            ..||.....::|....|..||:.|.|:.|...|:..:|....||         :.|.|:|::.|
Human  1020 GMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERAN- 1083

  Fly   344 SCNRLITLPDAIHL-----------LEGLDQLDLRN--------NPELVMPPK----------PS 379
                    |...||           :.....||||:        ..|.||..|          |:
Human  1084 --------PPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPT 1140

  Fly   380 EASKATS-----------LEFYNIDFSLQTQLRL---------AGAAVPPS------MPSS---- 414
            .....|:           :.:...|.|.|.|.:|         ||....|:      .||.
Human  1141 SEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSI 1205

  Fly   415 ----ATPKDSTARKIRLRRGPRSEG---------DQDAAKVL-----KGMKD------------- 448
                |..|.|.....|.|...|.||         .|:|.:.|     .|:.|
Human  1206 KERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKEEGGVADDSAISNLLWEPVY 1270

  Fly   449 -----------------------VAKDKDNE---------------------------------A 457
                                   |.:.::::                                 |
Human  1271 ASTYSPAIPAAHKYLSFVSINQRVTESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVA 1335

  Fly   458 GAVPEDG--KPESLKP--------KRWDESLEKPQLDYSKFFEKDDGQLPG-LTIWEIENF---L 508
            |.:.:.|  .|.::.|        .|....:.||..|..   .:.|.||.. |.:..:|.|   |
Human  1336 GRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIE---ARPDMQLESDLKLDRLETFLRRL 1397

  Fly   509 PNKI----------------------EEVVHGKFYEGDCYIVLKT--KFDDLGLLDWEIFF---- 545
            .||:                      ::....|||....|.:.::  :.|:    |:::.|
Human  1398 NNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDE----DFDVIFDPYA 1458

  Fly   546 -WIGNEATLDKRACAAIHAV----NLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGR-- 603
             .:.:.....|||......|    |....|.||...::|    .:||.|:     |.::|..|
Human  1459 PKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQE----YTEQRLN-----VAFMESKRMK 1514

  Fly   604 -------------TATGFYTIEEMIHIT-------------------RLYLVHAYG----ATIHL 632
                         |..|..:.|...:::                   ||.|:...|    .|..:
Human  1515 VEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLV 1579

  Fly   633 EPVAPAITSLDPRHAFVLDLGTH-IYIWMGERSKNTLNSKARLMAEKISKTERKNKCE---IQLE 693
            ||.|.|:.|.|   .|:| |..| .::|:||.:.....:||..:|..| :|:|:..|.   ||..
Human  1580 EPRASALNSGD---CFLL-LSPHCCFLWVGEFANVIEKAKASELATLI-QTKRELGCRATYIQTI 1639

  Fly   694 RQG-----EESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRLYQ---VQLGMGYLELPQVE 750
            .:|     ..:.:||:.||..:....|.:|.::           .||:   ::....|..:....
Human  1640 EEGINTHTHAAKDFWKLLGGQTSYQSAGDPKED-----------ELYEAAIIETNCIYRLMDDKL 1693

  Fly   751 LPEQKL------CHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELF---------- 799
            :|:...      | :||..|.|.:.|..::::||.||:.|...|..|.:|::.|:
Human  1694 VPDDDYWGKIPKC-SLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCD 1757

  Fly   800 -NMMD--------------RPDYALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGA 849
             |.:|              |||:|:..|:.|.||..:|:.||..|.|:        .:|..|...
Human  1758 INPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTEL--------KRSNEKNPG 1814

  Fly   850 NLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWN----------YDLEMMEA-------- 896
            .|.|  .:::.|||:.|..:.|..:||...|..:.:..|          :|....|.
Human  1815 ELAQ--HKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVW 1877

  Fly   897 FVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEI 961
            .:|| ..:.|||::.:|:|:.|:.||...::.:       .:..|:....:.|..:|..:
Human  1878 HILE-FDYSRLPKQSIGQFHEGDAYVVKWKFMV-------STAVGSRQKGEHSVRAAGKE----- 1929

  Fly   962 QCVVYFWQGRNAGNMGWLTFTFTLQKK-FKAMFGEELE-----VVRIFQQQENLKFMSHFKRKFI 1020
            :||.:|||||::          |:.:| ..|:...||:     .|::.|.:|...|:..|:...:
Human  1930 KCVYFFWQGRHS----------TVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMV 1984

  Fly  1021 IHTGKRKD---------KAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNS----TFCYI 1072
            :|:|:|::         :.:..:|:.|||            ..|:::   |.|.:|    |...:
Human  1985 VHSGRREEEEENVQSEWRLYCVRGEVPVE------------GNLLEV---ACHCSSLRSRTSMVV 2034

  Fly  1073 LHVPFETEDDSQSGIVYVWIGSKACNEEAKL----VQDIAEQ------MFNSPWVSLQILNEGDE 1127
            |:|        ...::|:|.|.||.....::    ...|.||      :.:|..|::...:||.|
Human  2035 LNV--------NKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSE 2091

  Fly  1128 PENFFWVALG--GRKPYD---TDAEYMNYT-RLFRCSNERGYYTVAE-----------KCADFCQ 1175
            |.. ||.|||  .||.||   .|....|:. |||..|:..|.:...|           ....|.|
Human  2092 PLG-FWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQ 2155

  Fly  1176 DDL---ADDDIMILDNGEHVFLWMG--PRCSEVEVKLA----------YKSA-QVYIQHMRIKQP 1224
            :||   ....:.::||...|:||.|  |    :|.|:.          .||| :..:|:.:.|..
Human  2156 EDLYSAPQPALFLVDNHHEVYLWQGWWP----IENKITGSARIRWASDRKSAMETVLQYCKGKNL 2216

  Fly  1225 ERPR-KLFLTMKNKESRRFTKCFHGW 1249
            ::|. |.:|.....|...||..|..|
Human  2217 KKPAPKSYLIHAGLEPLTFTNMFPSW 2242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566	1/1 (100%)
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064	43/210 (20%)
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566	13/56 (23%)
		leucine-rich repeat	102..124	CDD:275380	6/20 (30%)
		leucine-rich repeat	125..148	CDD:275380	6/23 (26%)
		leucine-rich repeat	149..171	CDD:275380	4/21 (19%)
		LRR_8	152..231	CDD:290566	18/84 (21%)
		leucine-rich repeat	172..195	CDD:275380	3/22 (14%)
		leucine-rich repeat	196..220	CDD:275380	3/23 (13%)
		leucine-rich repeat	221..243	CDD:275380	6/30 (20%)
		LRR_8	243..300	CDD:290566	10/56 (18%)
		leucine-rich repeat	244..266	CDD:275380	4/21 (19%)
		leucine-rich repeat	267..289	CDD:275380	3/21 (14%)
		leucine-rich repeat	290..314	CDD:275380	7/23 (30%)
		LRR_8	315..370	CDD:290566	16/82 (20%)
		leucine-rich repeat	315..335	CDD:275380	5/28 (18%)
		leucine-rich repeat	338..360	CDD:275378	5/32 (16%)
		gelsolin_S1_like	491..602	CDD:200446	30/147 (20%)
		gelsolin_like	618..706	CDD:200436	30/119 (25%)
		gelsolin_S3_like	729..828	CDD:200448	32/132 (24%)
		gelsolin_like	920..1015	CDD:200436	21/100 (21%)
		gelsolin_S5_like	1037..1141	CDD:200444	30/119 (25%)
		gelsolin_S6_like	1151..1250	CDD:200447	32/128 (25%)
SVIL	XP_024303906.1	gelsolin_S2_like	1562..1658	CDD:200445	30/100 (30%)
		gelsolin_like	1683..1783	CDD:200436	23/100 (23%)
		gelsolin_S4_like	1866..1979	CDD:200449	30/135 (22%)
		gelsolin_S5_like	1999..2104	CDD:200444	30/128 (23%)
		ADF_gelsolin	2121..2243	CDD:326633	32/126 (25%)
		VHP	2299..2334	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920