DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and avil

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001035455.1	Gene:	avil / 678618	ZFINID:	ZDB-GENE-060421-6683	Length:	811	Species:	Danio rerio

Alignment Length:	802	Identity:	217/802 - (27%)
Similarity:	346/802 - (43%)	Gaps:	147/802 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 GLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKT----KFDDLGLLDWEIFFWIGNEATLDKRAC 558
            |:.||.||......|.|..||:|::||||::|.|    |     .:.::|.:|||:.:::|::..
Zfish    13 GVLIWRIEKMDLVLIPEKFHGQFFDGDCYLLLSTCKSGK-----TISYDIHYWIGSASSIDEQGA 72

  Fly   559 AAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGG------RTATGFYTIEEMIHI 617
            ||::||.|..|||:.....||.|..||..|...|:..:||..||      ...|..|.|:.::|:
Zfish    73 AAMYAVQLDEFLGSTPVQHREVQQHESSMFCGYFKQGIIYKSGGVASGMNHVETNTYNIQRLLHV 137

  Fly   618 TRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKT 682
            .....|  .|..:.:     :..|.|....|:||||..|..|.|..|......|..::|:.|...
Zfish   138 KGRRKV--TGTEVEV-----SWKSFDTGSVFLLDLGKTIIQWNGPESNTQERLKGMMLAKDIRDR 195

  Fly   683 ERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHV----------------PEDY---- 727
            ||..:.||                |:...:|:||.|....|                |:|.
Zfish   196 ERGGRAEI----------------GVIEGDAEAAAPLLMQVMLSILGERPSTLPSGTPDDVTDRE 244

  Fly   728 QPVQPRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILD-CYTDLFVWFGKKSTRLVRAAA 791
            |..:..||.|....|.:::  .|:....|...|||....|||| ....:|||.||.:.:..|.||
Zfish   245 QMAKLTLYHVSDANGTMQI--TEIATSPLTQDLLNHDDCYILDQGGVSIFVWKGKMANKAERQAA 307

  Fly   792 VKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGW---DEVMAVDFTRTAKSVAKTGANLTQ 853
            :..:.|...:.:.|....|..:.:|.|..:|:..|..|   |:...:..|.|...:|..
Zfish   308 MTRALEFIKLKNYPLSTKVESICDGGESALFKQLFKNWTVKDQTQGLGRTHTVGKIADV------ 366

  Fly   854 WARQQETRTDLAALFMPRQSAMP-LAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYT 917
                .:.:.|.:.:.|     || :|..|::.::.:.:.::..   :||.:...:.:...|.||.
Zfish   367 ----PQEKFDASRMHM-----MPEVAAQERMVDDGSGEKQVWR---IENLELAEVSKATHGFFYG 419

  Fly   918 GECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGN-----MG 977
            |:||:.|..|.:      ||.::                      .::|.|:||:|..     ..
Zfish   420 GDCYLILYSYEV------NGRKN----------------------YILYMWRGRHASQDEVTACA 456

  Fly   978 WLTFTFTLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFF 1042
            :...|...|      :|.:...|.:...:|...|.|.||.|.:|:.|....|. ..:.:.||..|
Zfish   457 YHAVTVDQQ------YGGQPVQVSVTMGKEPRHFTSIFKGKMVIYEGGTSRKG-PVEPEPPVRLF 514

  Fly  1043 HLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDI 1107
            .:..:..: :||.:::...|..|||...::|        .|||| ||:|.|..:..:|..:.:|:
Zfish   515 QICGSHPS-STRAVEVPALAASLNSNDVFLL--------KSQSG-VYLWYGKGSSGDERAMAKDL 569

  Fly  1108 AEQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYDTDAEYMNYT-----RLFRCSNERGYYTVA 1167
            :..|..|.    |::.||.|||. ||.:||||.||.:|......|     |||.|||:.|.:|..
Zfish   570 SVIMGRSE----QVMAEGQEPEE-FWQSLGGRTPYASDRRLQQVTLEHQPRLFECSNKTGRFTAT 629

  Fly  1168 EKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQ-HMRIKQPERPRKLF 1231
            | ...|.||||.:||:|:||..:.:|||||...::||.:....:...|:: |...:.|:.|  :.
Zfish   630 E-VTQFTQDDLREDDVMLLDTWDQIFLWMGNEANDVERRECVPTCAEYLRTHPGSRDPDTP--IV 691

  Fly  1232 LTMKNKESRRFTKCFHGWSAFK 1253
            :..:..|...||..|..|...|
Zfish   692 IIKQGFEPPTFTGWFTAWDPSK 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	39/107 (36%)
		gelsolin_like	618..706	CDD:200436	20/87 (23%)
		gelsolin_S3_like	729..828	CDD:200448	28/99 (28%)
		gelsolin_like	920..1015	CDD:200436	18/99 (18%)
		gelsolin_S5_like	1037..1141	CDD:200444	34/103 (33%)
		gelsolin_S6_like	1151..1250	CDD:200447	35/104 (34%)
avil	NP_001035455.1	gelsolin_S1_like	5..116	CDD:200446	39/107 (36%)
		gelsolin_S2_like	132..226	CDD:200445	27/116 (23%)
		gelsolin_S3_like	250..344	CDD:200448	28/95 (29%)
		gelsolin_S4_like	388..488	CDD:200449	24/136 (18%)
		gelsolin_S5_like	509..598	CDD:200444	34/103 (33%)
		gelsolin_S6_like	613..710	CDD:200447	34/99 (34%)
		VHP	777..811	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920