DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and scin

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001038583.1	Gene:	scin / 566764	ZFINID:	ZDB-GENE-060503-6	Length:	733	Species:	Danio rerio

Alignment Length:	797	Identity:	227/797 - (28%)
Similarity:	350/797 - (43%)	Gaps:	115/797 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 YSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKT-KFDDLGLLDWEIFFWIG 548
            :.|.||| .|:..||.||.||......:.|..:|.||.||.|:||.| |..|....|  :.||:|
Zfish     4 HHKEFEK-AGKYSGLQIWRIEKMEIVPVPESFYGSFYTGDAYLVLHTVKQKDSSFYD--LHFWLG 65

  Fly   549 NEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGF-YTIE 612
            .|.:.|:...|||.:..:.::||.:....||.||.||..|.|.|:..:.|..|| .|:|| :.|.
Zfish    66 KECSQDESTAAAIFSTQMDDYLGGKPVQYREIQGFESTVFTSYFKGGIKYKSGG-VASGFQHVIT 129

  Fly   613 EMIHITRLYLVHAYG-ATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMA 676
            ..:...||:  |..| .|:....|..:..|.:....|::|||..||.|.|.:.......||..:.
Zfish   130 NDLTARRLF--HIKGRRTVRATEVPLSWASFNNGDCFIVDLGPVIYQWCGSKCNKFERIKAAQVG 192

  Fly   677 EKISKTERKNKCEIQLERQGEESAEFWQGLGMTSE--EADAAEPPKEHVPEDYQPVQPRLYQVQL 739
            ..|...||..:.::.:..:|:|.||..:.||:..|  |.|.:|   :.|.:........||.|..
Zfish   193 TGIRDNERSGRAKLVVIEEGQEPAEMTEVLGVKPEIPEGDDSE---DAVADVSNRKMASLYMVSD 254

  Fly   740 GMGYLELPQVELPEQKLCHTLLNSKHVYILDCYTD--LFVWFGKKSTRLVRAAAVKLSRELFNMM 802
            ..|.:::..|. .:.....:.|.|...:|||...:  :|||.|..:....|..|:|.:......|
Zfish   255 ATGKMQVSLVS-KDNPFDQSNLLSDECFILDHGKNKMIFVWKGHNANPSERKEAMKTAESFIKQM 318

  Fly   803 DRPDYALVMRVPEGNEMQIFRTKFAGW---DEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDL 864
            ..|....:..:|||.|..||:..|..|   |:...:......:.:||.         :||
Zfish   319 GYPQNTQIQVLPEGGETPIFKQFFKSWKEKDQAEGLGRVFVTERIAKI---------KQE----- 369

  Fly   865 AALFMPRQSAMPLAEAEQLEEEWNY--------DLEMMEAFVLENKKFVRLPEEELGRFYTGECY 921
                  :..|..|.|:.|:..::|.        ::..:|....:....|.:..|..|:||.|:||
Zfish   370 ------KFDASKLHESRQMAAQYNMVDDGAGKTEIWRVECGATKGDTKVPVDPETYGQFYGGDCY 428

  Fly   922 VFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQ 986
            :.|.||                     ||..           ::|.||| :...:..||.:..|.
Zfish   429 IILYRY---------------------SKGE-----------IIYTWQG-SRSTIDELTASAFLT 460

  Fly   987 KKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFII----HTGKRKDKAHTAKGKSPVEFFHLRSN 1047
            .:.....|.....||:.|.:|....:|.||.|.:|    .|.::..:|..|    |...|.:|.|
Zfish   461 VELDRSLGGNAVQVRVTQGKEPPHLLSLFKDKPLIVYKDGTSRKGGQAPAA----PTRLFQVRKN 521

  Fly  1048 GGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMF 1112
            .|.: ||:.:::..|..|||...|:|.:|        .|..|:|.|..|..||.|..:.::|::.
Zfish   522 LGTI-TRISEVDAKASSLNSNDVYLLKLP--------QGDGYIWKGKGASEEEEKAAKYMSEKLN 577

  Fly  1113 NSPWVSLQILNEGDEPENFFWVALGGRKPYDTDAEYMNYT-----RLFRCSNERGYYTVAEKCAD 1172
                ...:::.||.||: .||:||||:..|.|.....:.|     |||.|||:.|.:.:.|...:
Zfish   578 ----CKTKMVVEGKEPD-VFWMALGGKTEYQTSGLLESRTIAHPPRLFACSNKTGKFIIEEVPGE 637

  Fly  1173 FCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQP---ERPRKLFLTM 1234
            |.|||||:||:|:||..:.||:|:|...:|||...:.|||::||:    ..|   ::...|.:..
Zfish   638 FNQDDLAEDDVMLLDVWDSVFVWIGKDANEVERTESVKSAKIYIE----TDPSGRDKGTPLVVVK 698

  Fly  1235 KNKESRRFTKCFHGWSA 1251
            :..|...||..|..|.|
Zfish   699 QGHEPPTFTGWFLAWDA 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	41/111 (37%)
		gelsolin_like	618..706	CDD:200436	24/88 (27%)
		gelsolin_S3_like	729..828	CDD:200448	26/100 (26%)
		gelsolin_like	920..1015	CDD:200436	20/94 (21%)
		gelsolin_S5_like	1037..1141	CDD:200444	33/103 (32%)
		gelsolin_S6_like	1151..1250	CDD:200447	38/106 (36%)
scin	NP_001038583.1	gelsolin_S1_like	8..119	CDD:200446	43/113 (38%)
		gelsolin_S2_like	136..223	CDD:200445	24/88 (27%)
		gelsolin_S3_like	244..344	CDD:200448	26/100 (26%)
		gelsolin_S4_like	388..489	CDD:200449	27/133 (20%)
		gelsolin_S5_like	511..601	CDD:200444	34/107 (32%)
		gelsolin_S6_like	616..714	CDD:200447	37/101 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820