DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and svild

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_009304816.1	Gene:	svild / 562786	ZFINID:	ZDB-GENE-081104-483	Length:	1460	Species:	Danio rerio

Alignment Length:	1395	Identity:	288/1395 - (20%)
Similarity:	492/1395 - (35%)	Gaps:	355/1395 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EIPEELGHLQKLEHLSLNHNRLEKIFGELTELSCLRSLDLRH---NQLKNSGIPPELFHLEELTT 104
            ::...|..|:|.:.|:...|:.|:|..:.|:.:...|.|...   .:.||.....::.|.:..|.
Zfish   144 DMTSHLKGLEKADILATPKNQAEEISEKGTDFTSYSSSDKSEENAKERKNFKQDEKISHFQSFTA 208

  Fly   105 LDLSHNKLKEVPEGLERAKNLIVLN----LSNNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQ 165
                         |.|.|.|..|.|    ::....:......|:|:.|           .::.|
Zfish   209 -------------GQEDASNKDVGNARDQMAKENDQKAREKHFVHMED-----------SSIFP- 248

  Fly   166 TRRLINLKTLDLSHNPLELFQLRQLPSLQSLE-VLKMSGTQRTLLNFPTSIDSLANLCELDLSHN 229
              .::|:.....:..||   ..||....:|:: :||.|.:        ||         |||...
Zfish   249 --GVLNVDKEPTAATPL---LQRQDSGQRSIKGILKKSRS--------TS---------LDLEPG 291

  Fly   230 SLPKLPDCVYNVVTLVRLNLSDNELTELTAGVELWQRLESLNLSRNQLVALPAALCKLPKLRRLL 294
            ...:...|  ..:|:|..|...||..|........||.|| :.|.......|..:.|.|.|
Zfish   292 EQERTTIC--KELTVVDGNEEKNEEDEEDREERRLQREES-SSSETPRSPSPDTVDKSPSL---- 349

  Fly   295 VNDNKLNFEGIPSGIGKLGALEVFSAANNLLEMVPEGL-----CRCGALKQLNLSCNRLITLPDA 354
              ....:.|.:.|.:..       |.:::|.|.:.|..     || |.||...|:.....:|.:.
Zfish   350 --SQSEDGEELDSSLDG-------STSSSLKERLAEFKSDEIDCR-GKLKTNKLTNVVQTSLANR 404

  Fly   355 IHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYNIDFSLQTQLRLAGAAVPPSMPSSATPKD 419
            ...|:..:....:......:.||.|.|.:...|:      ..:.|.::.|         .....|
Zfish   405 YSQLQESENAWKKKKSSADVEPKMSLAERMKILQ------EKEEQWKVKG---------KGASND 454

  Fly   420 STARKI---RLRRGPRSEGDQDAAKVL----------KGMKDVAKDKDNEAGAVPEDGKPESLKP 471
            ||...:   ..:||..|...:|...:|          |.:::::...|.|.
Zfish   455 STQFSVAGRMAKRGLVSPSREDVPIILSKKACSSTPVKPLEEISTRPDAEG-------------- 505

  Fly   472 KRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVV-------HGKFYEGDCYIVL 529
               |:.|:|.:....|...|........||..:|    .|.:||:       .|:||:  |  :.
Zfish   506 ---DKRLDKLESFLDKLHNKGSLGTKNSTIEVME----EKEKEVMTFDDEETFGRFYK--C--LS 559

  Fly   530 KTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQG--------DE-- 584
            .|......|||.|..|.|....|....:....|..::|     .||..:..:.        |:
Zfish   560 PTALSSSVLLDEEEDFSIIQSNTPKLASAVEEHKRSVR-----PCRRAKSSRNPLRALAARDDLR 619

  Fly   585 ---SEQFLSLFETEVIYIEGGRTA-----------------------------TGFYTIEEMIHI 617
               :||.|::...|...|:..|.|                             |...|....:..
Zfish   620 QTYTEQRLNVASVETKRIQMERMAKHSNLADTALAGLASKENFKKVNLRSVKSTEVVTNNGAVPF 684

  Fly   618 TRLYLVHAYGAT-IHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISK 681
            .:|.|:|..|.. :.:..|.|...||:....::|......:.|.||.:.....:|...||:.| :
Zfish   685 HKLMLIHIKGRRHVQVRLVEPTANSLNSGDCYLLITPKQCFFWSGEFANVIEKAKGSEMAQYI-Q 748

  Fly   682 TERKNKCEIQLERQGEE--------SAEFWQGLGMTSEEADAAEPPKEHVPED--------YQPV 730
            |:|...|:.......||        :.|||..||..::...|.||.::.:.|.        |:.|
Zfish   749 TKRDLGCKASQVTVLEEGINTDNRLAKEFWSLLGGKTDYRGAGEPGEDELYESAIIESNCVYRLV 813

  Fly   731 QPRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLS 795
            :.:|  |.....:..:|.|         ::||||...:.|..::::||.||......|..||:|.
Zfish   814 EDKL--VPYDEAWASIPSV---------SMLNSKEALVFDFGSEVYVWTGKDVPLSDRKVAVQLG 867

  Fly   796 RELF-----------NMMD---------------RPDYALVMRVPEGNEMQIFRTKFAGW----- 829
            ::::           |.:|               ||.:||..|:.|.||..:||.||..|
Zfish   868 KQIWSGAYDYSTCRVNPLDPSSANKDNANRQGEGRPSWALFGRLSEHNETALFREKFLDWAERKP 932

  Fly   830 --DEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQ----LEEEWN 888
              ||.:..:...:......|   .....|..:.:..||.:.:|.:..:...:.::    :..|..
Zfish   933 PKDEPVVEEVKNSVHQFLPT---CDSELRPCDVKQMLAGVPLPVKMLLEGVDVQRGHGLVFSEDG 994

  Fly   889 YDLEM----MEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPI---EEPENGSEDGANPAA 946
            ...|:    ::|:.:.......:|.|.:|:.:.|:.||...:|.:..   :..:.|....|.|..
Zfish   995 RQAELATIAVDAWHIREFDDFEIPPESVGQLHEGDTYVIRWKYSVTNVVGKRQKPGELSTAGPGR 1059

  Fly   947 DVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEEL-----EVVRIFQQQ 1006
            :              :...:|||||::...|         :...|:...||     ..|.:.|.:
Zfish  1060 E--------------RTACFFWQGRHSSVSG---------RGTSALMTVELGNNKGAQVLVTQGK 1101

  Fly  1007 ENLKFMSHFKRKFIIHTGKRKD--------KAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAV 1063
            |...|:..|....:||.|.|:.        :....:|::.:|        |:    |:::...:.
Zfish  1102 EPPCFLQLFLGGLVIHKGCREGSSTNTGDWRLFCVRGETKME--------GS----LVEVECCSA 1154

  Fly  1064 HLNSTFCYILHVPFETEDDSQSGIVYVWIGSKA---CNEEAK-----LVQDIAEQMFNSPWVSLQ 1120
            .|.|....:|.       ..|:|.:|:|.|.|:   ..|..|     |.|....:|..:...||:
Zfish  1155 SLRSRASLLLL-------GVQNGQLYLWHGCKSHPGTREVGKRTVERLTQTCPREMGLNSNSSLK 1212

  Fly  1121 I--LNEGDEPENFFWVALGG--RKPYD---TDAEYMNYT-RLFRCSNERGYYTVAE--------- 1168
            :  :.||.|.:. ||.|||.  ||.||   .|....|:| |||..|...|.:...|
Zfish  1213 VNEMEEGTESKE-FWDALGNQDRKAYDCMLEDPGKYNFTPRLFLLSASGGTFQGEEIFGPAQVTG 1276

  Fly  1169 --KCADFCQDDL---ADDDIMILDNGEHVFLWMGPRCSEVEV----KLAYKS-----AQVYIQHM 1219
              ....|.|::|   ....:.::||...|:||.|.:..:.|:    |:.:.|     .:..:|:.
Zfish  1277 TIMAMPFLQENLYSAPQPALFLVDNRMEVYLWQGLQPDDTELTGSAKIRWDSERKCAMETTLQYC 1341

  Fly  1220 RIKQPERPRKLFLTMKNKESRRFTKCFHGW 1249
            :.|...||.:.:|.:...|...||..|..|
Zfish  1342 QEKNSRRPPQAYLILAGAEPLTFTNIFPYW 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380	2/9 (22%)
		LRR_8	53..112	CDD:290566	12/61 (20%)
		leucine-rich repeat	54..76	CDD:275380	5/21 (24%)
		LRR_RI	70..304	CDD:238064	47/241 (20%)
		leucine-rich repeat	77..101	CDD:275380	5/26 (19%)
		LRR_8	101..159	CDD:290566	10/61 (16%)
		leucine-rich repeat	102..124	CDD:275380	4/21 (19%)
		leucine-rich repeat	125..148	CDD:275380	4/26 (15%)
		leucine-rich repeat	149..171	CDD:275380	1/21 (5%)
		LRR_8	152..231	CDD:290566	15/79 (19%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..220	CDD:275380	5/24 (21%)
		leucine-rich repeat	221..243	CDD:275380	4/21 (19%)
		LRR_8	243..300	CDD:290566	15/56 (27%)
		leucine-rich repeat	244..266	CDD:275380	5/21 (24%)
		leucine-rich repeat	267..289	CDD:275380	5/21 (24%)
		leucine-rich repeat	290..314	CDD:275380	3/23 (13%)
		LRR_8	315..370	CDD:290566	12/59 (20%)
		leucine-rich repeat	315..335	CDD:275380	5/24 (21%)
		leucine-rich repeat	338..360	CDD:275378	5/21 (24%)
		gelsolin_S1_like	491..602	CDD:200446	29/130 (22%)
		gelsolin_like	618..706	CDD:200436	24/96 (25%)
		gelsolin_S3_like	729..828	CDD:200448	32/124 (26%)
		gelsolin_like	920..1015	CDD:200436	19/102 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	28/115 (24%)
		gelsolin_S6_like	1151..1250	CDD:200447	29/123 (24%)
svild	XP_009304816.1	Ehrlichia_rpt	8..>424	CDD:118064	68/343 (20%)
		gelsolin_S2_like	686..782	CDD:200445	24/96 (25%)
		ADF_gelsolin	806..882	CDD:301701	19/86 (22%)
		gelsolin_S4_like	1004..1110	CDD:200449	24/128 (19%)
		ADF_gelsolin	1131..1234	CDD:301701	28/122 (23%)
		ADF_gelsolin	1251..1372	CDD:301701	28/121 (23%)
		VHP	1426..1460	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920