DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and flii

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001244075.1	Gene:	flii / 560281	ZFINID:	ZDB-GENE-071212-3	Length:	1259	Species:	Danio rerio

Alignment Length:	1282	Identity:	714/1282 - (55%)
Similarity:	939/1282 - (73%)	Gaps:	63/1282 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLPFVRGVDFTKNDF-SATFPSSMRQMSRVQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEK 66
            ||||:||||.:.||| ...||..::.|:.::||.|:||.|..:||||..||||||||::||.|..
Zfish     6 VLPFIRGVDLSGNDFKGGNFPEHVKSMTSLRWLKLNRTGLCYLPEELASLQKLEHLSVSHNSLTT 70

  Fly    67 IFGELTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLS 131
            :.|||:.|..||::..|.|.|||||:|.::|.|::|:.||||||:|.|:|..||.::|::|||||
Zfish    71 LHGELSSLPNLRAVVARANNLKNSGVPDDIFQLDDLSVLDLSHNQLTEIPRDLENSRNMLVLNLS 135

  Fly   132 NNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSL 196
            :|.|::||..|||:|||||:||||.|.|::||||.|||::|:||.|::|||...||||||.:.||
Zfish   136 HNSIDNIPNQLFINLTDLLYLDLSDNNLDSLPPQMRRLVHLQTLILNNNPLMHAQLRQLPVMVSL 200

  Fly   197 EVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELTAGV 261
            :.|.:..||||..|.|||::.|:||.::|||.|.|.::|:|:|::|.|.|||||.|:::||:..:
Zfish   201 QTLHLRNTQRTQNNMPTSLEGLSNLTDVDLSCNDLTRVPECLYSLVNLKRLNLSSNQISELSLCI 265

  Fly   262 ELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLE 326
            :.|.:||:||||||||.:||:|:|||.||::|.||.||::|:|:|||:|||..|..|.||||.||
Zfish   266 DQWTKLETLNLSRNQLTSLPSAICKLSKLKKLYVNSNKIDFDGLPSGVGKLSNLVEFMAANNNLE 330

  Fly   327 MVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYN 391
            :|||||||||.||:|.|:.|||:|||:|||.|..|:.||:|.||.|||||||.:    .:.|:||
Zfish   331 LVPEGLCRCGKLKKLVLNKNRLVTLPEAIHFLTELEVLDVRENPNLVMPPKPVD----RTAEWYN 391

  Fly   392 IDFSLQTQLRLAGAAVPPSMPSSA----TPKDSTARKIRLRRGPRSEGDQDAAKVLKGMKDVAKD 452
            ||||||.|||||||:  |:..::|    :|:|..|||:||||...|..|..|.:|||||.|||::
Zfish   392 IDFSLQNQLRLAGAS--PATVAAAGGGNSPRDHMARKMRLRRCKDSAHDDQAKQVLKGMSDVAQE 454

  Fly   453 KDNEAGAVPEDG--KPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEV 515
            |:.   ::.|:|  |...||.||||::|||||||||:||.:|.||:||:::|:||||:|.:::|.
Zfish   455 KNK---SIEENGDLKYSDLKTKRWDKNLEKPQLDYSEFFLEDVGQIPGVSVWQIENFIPIQVDEA 516

  Fly   516 VHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREE 580
            .||||||.||||:|||..|:.|.|:|:||:|||.:|||||:|.||||||||||:|||.|||:|||
Zfish   517 FHGKFYEADCYIILKTFLDENGALNWQIFYWIGQDATLDKKAGAAIHAVNLRNYLGAECRTIREE 581

  Fly   581 QGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLVHAYG-ATIHLEPVAPAITSLDP 644
            .|||||:|..:|:.|:.||||| ||:||||:|:..:.||||.|  || ..|.||.|....:||||
Zfish   582 MGDESEEFTVVFDHEISYIEGG-TASGFYTVEDTQYPTRLYRV--YGKKNIRLESVPLKASSLDP 643

  Fly   645 RHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMT 709
            :..|:||.|..||:|.|..:.....:||||.||||:|.|||:|.||....|.:|..|||:.||..
Zfish   644 QFVFLLDTGLEIYVWRGGNATLGGTTKARLFAEKINKNERKSKAEITTLMQNQEPPEFWEVLGGQ 708

  Fly   710 SEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYLELPQVE---------------LPEQKLCHT 759
            .||.      |:|||:|:.|::|:||:|.||:|||||||:.               :||.:|...
Zfish   709 PEEI------KKHVPDDFTPIRPKLYKVGLGLGYLELPQINYKLSVEHKDKLKLDVVPELRLVQG 767

  Fly   760 LLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRT 824
            ||::|.||||||::|:|:|.|:||.|||||||:||.:|:..|:.||.:|:|:|..||.|.|:|::
Zfish   768 LLDTKGVYILDCWSDVFIWIGRKSPRLVRAAALKLGQEVCGMLHRPKHAVVIRNLEGTECQVFKS 832

  Fly   825 KFAGWDEVMAVDFTRTAKSVAKTGANLT-----QWARQQETRTDLAALFMPRQSAMPLAEAEQLE 884
            ||..||:|:.||:||.|:|| |..|.|:     ...::.:.:.||.|||:|||.||||.||||:.
Zfish   833 KFKNWDDVLKVDYTRNAESV-KQEAGLSGKVKKDVEQKDQMKADLTALFLPRQPAMPLTEAEQMM 896

  Fly   885 EEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIE---EPENGSEDGANPAA 946
            ||||.||:.||.||||.|||.||||||.|.|:|.:||||||||.:|:|   :.|.|.|.| ....
Zfish   897 EEWNEDLDGMEGFVLEGKKFARLPEEEFGHFHTQDCYVFLCRYWVPVEYEDDKEKGKEKG-EEGD 960

  Fly   947 DVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVRIFQQQENLKF 1011
            |..|     |||::.||||||||||.|.|||||||||:|||||:::|..:|||||:.||||||||
Zfish   961 DEEK-----QPEEDFQCVVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENLKF 1020

  Fly  1012 MSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVP 1076
            :||||||||||.||||.|..:.:    ...:|:|:||.||.||.|||..|:.:|||.||:||.||
Zfish  1021 LSHFKRKFIIHKGKRKLKVDSVQ----PSLYHIRTNGSALCTRTIQIATDSSNLNSEFCFILKVP 1081

  Fly  1077 FETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGRKP 1141
            ||:.|:  .||||.|:|..|..:||||.::|...||:..: |.|::|||:||||||||.:|.:|.
Zfish  1082 FESTDN--QGIVYTWVGRAADPDEAKLAEEIMNTMFDDTY-SKQVINEGEEPENFFWVGIGSQKT 1143

  Fly  1142 YDTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVK 1206
            ||.|||||.|.||||||||:||:.|:|||:|||||||||||||:||||:.|::|:|.:.|:||:|
Zfish  1144 YDEDAEYMKYARLFRCSNEKGYFAVSEKCSDFCQDDLADDDIMLLDNGKEVYMWVGTQTSQVEIK 1208

  Fly  1207 LAYKSAQVYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGWSAFK 1253
            |:.|:.||||||||.|..|.||||.|..|..|...||:|||.|||||
Zfish  1209 LSLKACQVYIQHMRSKDTENPRKLRLVRKGNEPHCFTRCFHAWSAFK 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	10/23 (43%)
		leucine-rich repeat	31..53	CDD:275380	11/21 (52%)
		LRR_8	53..112	CDD:290566	32/58 (55%)
		leucine-rich repeat	54..76	CDD:275380	12/21 (57%)
		LRR_RI	70..304	CDD:238064	128/233 (55%)
		leucine-rich repeat	77..101	CDD:275380	12/23 (52%)
		LRR_8	101..159	CDD:290566	35/57 (61%)
		leucine-rich repeat	102..124	CDD:275380	12/21 (57%)
		leucine-rich repeat	125..148	CDD:275380	13/22 (59%)
		leucine-rich repeat	149..171	CDD:275380	15/21 (71%)
		LRR_8	152..231	CDD:290566	44/78 (56%)
		leucine-rich repeat	172..195	CDD:275380	13/22 (59%)
		leucine-rich repeat	196..220	CDD:275380	11/23 (48%)
		leucine-rich repeat	221..243	CDD:275380	9/21 (43%)
		LRR_8	243..300	CDD:290566	32/56 (57%)
		leucine-rich repeat	244..266	CDD:275380	10/21 (48%)
		leucine-rich repeat	267..289	CDD:275380	16/21 (76%)
		leucine-rich repeat	290..314	CDD:275380	14/23 (61%)
		LRR_8	315..370	CDD:290566	35/54 (65%)
		leucine-rich repeat	315..335	CDD:275380	14/19 (74%)
		leucine-rich repeat	338..360	CDD:275378	14/21 (67%)
		gelsolin_S1_like	491..602	CDD:200446	70/110 (64%)
		gelsolin_like	618..706	CDD:200436	43/88 (49%)
		gelsolin_S3_like	729..828	CDD:200448	55/113 (49%)
		gelsolin_like	920..1015	CDD:200436	59/97 (61%)
		gelsolin_S5_like	1037..1141	CDD:200444	52/103 (50%)
		gelsolin_S6_like	1151..1250	CDD:200447	63/98 (64%)
flii	NP_001244075.1	LRR_RI	<10..163	CDD:238064	82/152 (54%)
		leucine-rich repeat	10..34	CDD:275380	10/23 (43%)
		LRR_8	33..91	CDD:290566	29/57 (51%)
		leucine-rich repeat	35..57	CDD:275380	11/21 (52%)
		leucine-rich repeat	58..80	CDD:275380	12/21 (57%)
		LRR_8	79..139	CDD:290566	31/59 (53%)
		leucine-rich repeat	83..105	CDD:275380	10/21 (48%)
		LRR_RI	91..374	CDD:238064	163/282 (58%)
		leucine-rich repeat	106..128	CDD:275380	12/21 (57%)
		LRR_8	127..186	CDD:290566	36/58 (62%)
		leucine-rich repeat	129..152	CDD:275380	13/22 (59%)
		leucine-rich repeat	153..175	CDD:275380	15/21 (71%)
		leucine-rich repeat	176..199	CDD:275380	13/22 (59%)
		leucine-rich repeat	200..224	CDD:275380	11/23 (48%)
		LRR_8	223..281	CDD:290566	29/57 (51%)
		leucine-rich repeat	225..247	CDD:275380	9/21 (43%)
		leucine-rich repeat	248..270	CDD:275380	10/21 (48%)
		leucine-rich repeat	271..293	CDD:275380	16/21 (76%)
		leucine-rich repeat	294..318	CDD:275380	14/23 (61%)
		leucine-rich repeat	319..339	CDD:275380	14/19 (74%)
		leucine-rich repeat	342..364	CDD:275378	14/21 (67%)
		gelsolin_S1_like	491..603	CDD:200446	70/111 (63%)
		gelsolin_like	617..705	CDD:200436	43/89 (48%)
		gelsolin_S3_like	722..836	CDD:200448	55/113 (49%)
		gelsolin_like	931..1024	CDD:200436	59/98 (60%)
		gelsolin_S5_like	1043..1142	CDD:200444	52/105 (50%)
		gelsolin_S6_like	1153..1252	CDD:200447	63/98 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577509
Domainoid	1	1.000	394	1.000	Domainoid score	I738
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11092
Inparanoid	1	1.050	1401	1.000	Inparanoid score	I120
OMA	1	1.010	-	-		QHG52569
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0007001
OrthoInspector	1	1.000	-	-		oto39051
orthoMCL	1	0.900	-	-		OOG6_106545
Panther	1	1.100	-	-	LDO	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5098
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910