DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and vill

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_021325987.1	Gene:	vill / 555361	ZFINID:	ZDB-GENE-081222-1	Length:	910	Species:	Danio rerio

Alignment Length:	808	Identity:	226/808 - (27%)
Similarity:	353/808 - (43%)	Gaps:	126/808 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 DYSKFFEKDD-----GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEI 543
            ::|:..|..|     .:.|||.||.|.......:.|...|.|:||||||:|....:....:|  |
Zfish    57 EFSRMTEAHDLFKNIQRKPGLQIWTINKMQMVAVPEQAFGNFFEGDCYIILNVSNNPAQSID--I 119

  Fly   544 FFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGF 608
            .:||||.::.|::..|||:...|....|......||.||.||.:|.|.|:..:||.:|| .|:||
Zfish   120 HYWIGNSSSQDEQGAAAIYVTQLDENFGGSPVQYREVQGHESVKFKSYFKNGLIYKKGG-VASGF 183

  Fly   609 -------YTIEEMIHI--TRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERS 664
                   |.|:.::|:  |:    |..|..:.:     :..|.:....|:||||..|..|.|.:|
Zfish   184 THVETNVYNIQRLLHVKGTK----HVTGREVEV-----SWNSFNLGDVFLLDLGKAIIQWNGPQS 239

  Fly   665 KNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPEDYQP 729
            ......||.::|:.|...||..:.:|.:....:|.|.......|.|.........||.:|:| :|
Zfish   240 NRQEKLKAVMLAQDIRDRERGGRAQIGVIEGAQEEASPELMKVMVSVLGQRIGQMKEAIPDD-KP 303

  Fly   730 VQ-----PRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILD-CYTDLFVWFGKKSTRLVR 788
            .|     .:||||....|.|.:.:|.:  ..|...||.|...|||| ..|.:.||.||.::...|
Zfish   304 GQNQISNVKLYQVSDASGQLLVQEVAV--SPLTQDLLCSSDCYILDQGGTSIMVWKGKGASNEER 366

  Fly   789 AAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQ 853
            .:|:..:.......:.|....|..:.||.|..:|:..|..|.|...........||.|.
Zfish   367 RSAMGRAVGFIKAKNYPASTKVEVMSEGGESAMFKQLFKSWTEKGQTQGLGKTHSVGKI------ 425

  Fly   854 WARQQETRTDLAALFMPRQSAMP-LAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYT 917
             |:..:.:.|:..|     .|.| ||..|::.::.:..:::..   :||.:...:.....|:||.
Zfish   426 -AKVDQVKFDVMEL-----HAQPKLAAQERMVDDASGQVQVWR---IENLELKEVDRSTYGQFYG 481

  Fly   918 GECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFT 982
            |:||:.|..|               |.|         |:|    |.::|.||||:|.........
Zfish   482 GDCYLVLYTY---------------NRA---------NKP----QYILYIWQGRHATQDEVTASA 518

  Fly   983 F---TLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPV----- 1039
            :   .|..|:.   |...: ||:...:|...||:.||.:.||..|        ..|:|.|
Zfish   519 YQAVNLDNKYN---GAPTQ-VRVVMGKEPRHFMAIFKGRLIIFEG--------GTGRSGVVNPDP 571

  Fly  1040 --EFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAK 1102
              ..|.:|.. ..|.|:..::...|..||:...::|.. ::|        |::|.|.....:|.:
Zfish   572 AARLFQVRGT-HELNTKATEVPARASSLNTNDVFLLKT-YQT--------VFLWYGKGCSGDERE 626

  Fly  1103 LVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYDTDAEY-----MNYTRLFRCSNERG 1162
            :.:.:|:.:...   ..|.:.||.||. .|||.|||:.||.:|...     ::..|||.|||:.|
Zfish   627 MGKAVADLLSGQ---DKQTVMEGQEPA-AFWVPLGGKAPYASDKRLEEEVSLHEPRLFECSNQTG 687

  Fly  1163 YYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQ-HMRIKQPER 1226
            .:.:.| .|||.||||.:||:|:||..:.:|||:|...::.|::.:..||..|:: |...:....
Zfish   688 RFLMTE-VADFTQDDLDEDDVMLLDTWDEIFLWIGNSANQYEIQESSSSAVEYLKTHPAGRDAGT 751

  Fly  1227 PRKLFLTMK-NKESRRFTKCFHGWSAFK 1253
            |   ..|:| ..|...||..|:.|.|.|
Zfish   752 P---ITTVKQGYEPPTFTGWFNAWDAHK 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	40/115 (35%)
		gelsolin_like	618..706	CDD:200436	22/87 (25%)
		gelsolin_S3_like	729..828	CDD:200448	31/104 (30%)
		gelsolin_like	920..1015	CDD:200436	23/97 (24%)
		gelsolin_S5_like	1037..1141	CDD:200444	27/110 (25%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/100 (36%)
vill	XP_021325987.1	gelsolin_S1_like	68..178	CDD:200446	39/111 (35%)
		gelsolin_S2_like	194..282	CDD:200445	23/96 (24%)
		gelsolin_S3_like	309..406	CDD:200448	29/98 (30%)
		gelsolin_S4_like	450..550	CDD:200449	29/134 (22%)
		gelsolin_S5_like	571..661	CDD:200444	25/103 (24%)
		gelsolin_S6_like	676..773	CDD:200447	36/100 (36%)
		VHP	876..910	CDD:308044
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820