DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and flii

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001015848.1	Gene:	flii / 548565	XenbaseID:	XB-GENE-478681	Length:	1270	Species:	Xenopus tropicalis

Alignment Length:	1292	Identity:	711/1292 - (55%)
Similarity:	940/1292 - (72%)	Gaps:	72/1292 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLPFVRGVDFTKNDF-SATFPSSMRQMSRVQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEK 66
            ||||:||||.:.||| ...||..::.||.::||.|:||.|..:||||..|.||||||::||.|..
Frog     6 VLPFIRGVDLSGNDFKGGYFPEHVKSMSSLRWLKLNRTGLCYLPEELSSLHKLEHLSVSHNSLTT 70

  Fly    67 IFGELTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLS 131
            :.|||:.|.|||::..|.|.|||||||.::|.|::|:.||||:|:|.|.|..||.|||::|||||
Frog    71 LHGELSSLPCLRAIVARANSLKNSGIPDDIFQLDDLSVLDLSYNQLTECPRELENAKNMLVLNLS 135

  Fly   132 NNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSL 196
            :|.|::||..|||:||||::||||.|:|::||||.|||::|:||.|::|||...||||||::.:|
Frog   136 HNSIDNIPNQLFINLTDLIYLDLSDNKLDSLPPQMRRLVHLQTLILNNNPLLHAQLRQLPAMTAL 200

  Fly   197 EVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELTAGV 261
            :.|.:..||||..|.|||::.|..|.::|||.|.:.::|:|:|.:.:|.|||||.|:::|::..:
Frog   201 QTLHLRNTQRTQSNMPTSLEVLTCLSDVDLSMNEMTRIPECLYTLASLKRLNLSSNQISEISLCI 265

  Fly   262 ELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLE 326
            :.|.:||:|||:||||.:||:|:|||.||::|.:|.||::|:|||||||||..||||.||||.||
Frog   266 DQWAQLETLNLARNQLTSLPSAICKLAKLKKLYLNSNKMDFDGIPSGIGKLSNLEVFMAANNNLE 330

  Fly   327 MVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYN 391
            ::||.||||..|::|.|:.|||:|||:|:|.|..|:.||:|.||.|||||||::.:.    ||||
Frog   331 LIPESLCRCSKLRKLVLNKNRLVTLPEAVHFLTDLEVLDVRENPSLVMPPKPADRTS----EFYN 391

  Fly   392 IDFSLQTQLRLAGAAVPPSMPSSA-----TPKDSTARKIRLRRGPRSEGDQDAAKVLKGMKDVAK 451
            ||||||.|||||||: |.::.::|     ..||.:|||:||||...:..|..|.:|||||.|||:
Frog   392 IDFSLQNQLRLAGAS-PATVAAAAAAGGSATKDPSARKMRLRRRKDTSQDDQAKQVLKGMSDVAE 455

  Fly   452 DKDNEAGAVPEDG--KPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEE 514
            :|:.:   :.|:|  |...||.:|||:.||||.||||:||.:|.||:||:|:|:||||:|.:::|
Frog   456 EKNKK---IQENGDMKYTDLKARRWDQGLEKPHLDYSEFFTEDVGQIPGVTVWQIENFIPTQVDE 517

  Fly   515 VVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVRE 579
            ..||:|||.||||||||..|..|.|.|||::|||.||||||:||:|||||||||:|||..||:||
Frog   518 TFHGRFYEADCYIVLKTYLDSNGALHWEIYYWIGQEATLDKKACSAIHAVNLRNYLGAEGRTIRE 582

  Fly   580 EQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLVHAYG-ATIHLEPVAPAITSLD 643
            |.|||||:|..:|..::.||||| ||:||||:|:..:|||||.:  || ..|.|||:....:|||
Frog   583 EMGDESEEFSQVFYNDISYIEGG-TASGFYTVEDTQYITRLYRI--YGKKNIRLEPMPLKSSSLD 644

  Fly   644 PRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGM 708
            ||..|:||.|..||:|.|.::..:..:||||.||||:|.|||.|.||.|.....|:||||:.||.
Frog   645 PRFVFLLDHGMDIYVWRGSQATLSNTTKARLFAEKINKNERKGKAEIILLTHEMETAEFWELLGG 709

  Fly   709 TSEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYLELPQVE---------------LPEQKLCH 758
            ..||.      |..||:|:||.:|:||:|.||:|||||||:.               :||.:|.|
Frog   710 QPEEL------KPCVPDDFQPPRPKLYKVGLGLGYLELPQINYKISVEHKKRPKIELMPEMRLLH 768

  Fly   759 TLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFR 823
            |||::|.||||||::|:|:|.|:||:|||||||:||.:||.:|:.||.:|:|:|..||.|.|:|:
Frog   769 TLLDTKSVYILDCHSDIFIWIGRKSSRLVRAAALKLGQELCSMLHRPKHAMVIRNLEGTECQVFK 833

  Fly   824 TKFAGWDEVMAVDFTRTAKSVAKTGANLT----QWARQQETRTDLAALFMPRQSAMPLAEAEQLE 884
            :||..||:|:.||:||.|:||.: |..||    :.|.:.:.:.||.|||:|||..||::|||||.
Frog   834 SKFRNWDDVLKVDYTRNAESVVQ-GGGLTGKVKKDAEKDQMKADLTALFLPRQPPMPISEAEQLT 897

  Fly   885 EEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPE-------------N 936
            ||||.||:.||.||||.|||.||||||.|.|.|.:||||||||.||||:.|             :
Frog   898 EEWNEDLDGMEGFVLEGKKFARLPEEEFGHFNTQDCYVFLCRYWIPIEQDEEEEQKSKKRKIHGD 962

  Fly   937 GSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVR 1001
            |.||      :..:...:.|||::.||||||||||.|.|||||||||:|||||:::|..:|||||
Frog   963 GEED------EDEEDEEDKQPEEDFQCVVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 1021

  Fly  1002 IFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLN 1066
            :.|||||.||:||||||||||.||||.|   ..|..| ..:|:|:||.||.||.||||.|...||
Frog  1022 MTQQQENAKFLSHFKRKFIIHKGKRKSK---DVGLQP-SLYHVRTNGSALCTRCIQINTDCSLLN 1082

  Fly  1067 STFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENF 1131
            |.||:||.||||:.|:  .||||.|:|..|..:||||.:||...||:..: |.|::|||:|||||
Frog  1083 SEFCFILKVPFESIDN--QGIVYTWVGRAADPDEAKLSEDIMNHMFDDTY-SKQVINEGEEPENF 1144

  Fly  1132 FWVALGGRKPYDTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWM 1196
            |||.:||:|.||.||:||.:.||||||||:||::|:|||:|||||||||||||:||||:.|::|:
Frog  1145 FWVGIGGQKAYDEDADYMKHARLFRCSNEKGYFSVSEKCSDFCQDDLADDDIMLLDNGKEVYMWV 1209

  Fly  1197 GPRCSEVEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGWSAFK 1253
            |.:.|:||:||:.|:.||||||||.|..|.||||.|..|..|...||:|||.|.||:
Frog  1210 GTQTSQVEIKLSLKACQVYIQHMRAKDAEHPRKLRLVRKGNEPHAFTRCFHAWGAFR 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	10/23 (43%)
		leucine-rich repeat	31..53	CDD:275380	11/21 (52%)
		LRR_8	53..112	CDD:290566	33/58 (57%)
		leucine-rich repeat	54..76	CDD:275380	12/21 (57%)
		LRR_RI	70..304	CDD:238064	123/233 (53%)
		leucine-rich repeat	77..101	CDD:275380	13/23 (57%)
		LRR_8	101..159	CDD:290566	35/57 (61%)
		leucine-rich repeat	102..124	CDD:275380	12/21 (57%)
		leucine-rich repeat	125..148	CDD:275380	13/22 (59%)
		leucine-rich repeat	149..171	CDD:275380	14/21 (67%)
		LRR_8	152..231	CDD:290566	42/78 (54%)
		leucine-rich repeat	172..195	CDD:275380	13/22 (59%)
		leucine-rich repeat	196..220	CDD:275380	11/23 (48%)
		leucine-rich repeat	221..243	CDD:275380	8/21 (38%)
		LRR_8	243..300	CDD:290566	29/56 (52%)
		leucine-rich repeat	244..266	CDD:275380	9/21 (43%)
		leucine-rich repeat	267..289	CDD:275380	15/21 (71%)
		leucine-rich repeat	290..314	CDD:275380	15/23 (65%)
		LRR_8	315..370	CDD:290566	32/54 (59%)
		leucine-rich repeat	315..335	CDD:275380	14/19 (74%)
		leucine-rich repeat	338..360	CDD:275378	12/21 (57%)
		gelsolin_S1_like	491..602	CDD:200446	70/110 (64%)
		gelsolin_like	618..706	CDD:200436	44/88 (50%)
		gelsolin_S3_like	729..828	CDD:200448	58/113 (51%)
		gelsolin_like	920..1015	CDD:200436	58/107 (54%)
		gelsolin_S5_like	1037..1141	CDD:200444	56/103 (54%)
		gelsolin_S6_like	1151..1250	CDD:200447	62/98 (63%)
flii	NP_001015848.1	LRR_RI	<10..163	CDD:238064	84/152 (55%)
		leucine-rich repeat	10..34	CDD:275380	10/23 (43%)
		LRR_8	33..91	CDD:290566	30/57 (53%)
		leucine-rich repeat	35..57	CDD:275380	11/21 (52%)
		leucine-rich repeat	58..80	CDD:275380	12/21 (57%)
		leucine-rich repeat	81..105	CDD:275380	13/23 (57%)
		LRR_RI	89..375	CDD:238064	158/285 (55%)
		leucine-rich repeat	106..128	CDD:275380	12/21 (57%)
		leucine-rich repeat	129..152	CDD:275380	13/22 (59%)
		LRR_8	131..186	CDD:290566	34/54 (63%)
		leucine-rich repeat	153..175	CDD:275380	14/21 (67%)
		leucine-rich repeat	176..199	CDD:275380	13/22 (59%)
		leucine-rich repeat	200..224	CDD:275380	11/23 (48%)
		LRR_8	225..281	CDD:290566	24/55 (44%)
		leucine-rich repeat	225..247	CDD:275380	8/21 (38%)
		leucine-rich repeat	248..270	CDD:275380	9/21 (43%)
		LRR_8	270..352	CDD:290566	51/81 (63%)
		leucine-rich repeat	271..318	CDD:275380	31/46 (67%)
		leucine-rich repeat	319..341	CDD:275380	16/21 (76%)
		gelsolin_S1_like	493..605	CDD:200446	70/111 (63%)
		gelsolin_like	620..707	CDD:200436	44/88 (50%)
		gelsolin_S3_like	724..838	CDD:200448	58/113 (51%)
		gelsolin_like	932..1035	CDD:200436	58/108 (54%)
		gelsolin_S5_like	1054..1153	CDD:200444	56/102 (55%)
		gelsolin_S6_like	1164..1262	CDD:200447	62/97 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	393	1.000	Domainoid score	I772
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11092
Inparanoid	1	1.050	1403	1.000	Inparanoid score	I127
OMA	1	1.010	-	-		QHG52569
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0007001
OrthoInspector	1	1.000	-	-		oto104550
Panther	1	1.100	-	-	LDO	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2528
SonicParanoid	1	1.000	-	-		X5098
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110