DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Gel

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	210/809 - (25%)
Similarity:	343/809 - (42%)	Gaps:	155/809 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKT---KFDDLGLLDWEIFFWIGNEATLDK 555
            |:.|||.||.||||.|....:..:||||.||.:|||.|   |.|.  .|.|::.||:|.|.:.|:
  Fly    67 GRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDK--KLSWDVHFWLGLETSTDE 129

  Fly   556 RACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIH-ITR 619
            ...|||..|.|.:.|.......||.|..||:.|||.|:..:.|.:|| ..|||..:|.... .||
  Fly   130 AGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGG-VGTGFKHVETNAQGETR 193

  Fly   620 LYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTER 684
            |:.|.. ...:.:..|..:::|::....|:||.|:.||:::|.::|.....||...|.:|...:.
  Fly   194 LFQVKG-KRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDH 257

  Fly   685 KNKCEIQLERQGEESAE---FWQ--GLGMTSEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYL 744
            ..:..:|:.......|:   |:.  |.|...:..|.:...::...|........||:|....|.|
  Fly   258 NGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKL 322

  Fly   745 ELPQVELPEQK-LCHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYA 808
               :|::..|| |...:|:::..:|||..:.:|||.||.:|:..:..|:..::|.......|.:.
  Fly   323 ---KVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWT 384

  Fly   809 LVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQS 873
            .:.|:.||:|...|:..|..|.:               .|.:.::..|                |
  Fly   385 QIHRIVEGSESAPFKQYFDTWRD---------------AGMSHSRLIR----------------S 418

  Fly   874 AMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENG- 937
            |:.:...|.|.:      :.:::.|.:.||            ..|..:.|:         |::|
  Fly   419 ALGIGSDELLND------DEIDSVVTQLKK------------SGGRAFGFM---------PDHGQ 456

  Fly   938 ------SEDGANPAADVSKSSANNQPEDE--------IQCVVYFWQGRNAGNMGWLTFTFTLQKK 988
                  ::..|.|.:|  :...:..|.||        ...:.|.::..| |:.|.||:.:...|.
  Fly   457 NVIETITQYVAKPGSD--EIVVSTVPFDEKLPLLGFASYVLTYNYEANN-GDTGSLTYVWHGVKA 518

  Fly   989 F----KAMFGEELE------VVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPV--EF 1041
            .    |..|.|.|.      :|:..|..|...|...||.|.:           |:....||  :.
  Fly   519 SAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLL-----------TSFTALPVTAQL 572

  Fly  1042 FHLRSNGGALTT--RLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVW--IGSKACNEEAK 1102
            |.:|   |.:.:  ...::..|:..|.|:..::||       ..:|..:|:|  :|:.|..::|
  Fly   573 FRIR---GTVESDVHASEVAADSSSLASSDAFVLH-------SGKSHKIYIWNGLGASAFEKQA- 626

  Fly  1103 LVQDIAEQMFNSPW--VSLQILNEGDEPENFFWVALGGRKPYD----TDAEYMNYTRLFRCSNER 1161
                 |...|:..|  |.|:.:.||.||:. ||..|.|...||    .|...:..:|||.|....
  Fly   627 -----AVDRFSDYWDDVELEQVEEGAEPDE-FWEELNGEGQYDRSLGDDGAPLLESRLFHCHLSS 685

  Fly  1162 GYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQPER 1226
            |.:...|:.|.:.|:||..||||:||.|:.::||:|...||.|......:|::|.      ..|.
  Fly   686 GGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYF------NLEP 744

  Fly  1227 PRKLFLTM------KNKESRRFTKCFHGW 1249
            ..:.|.|:      :.||.|.|.:.|..|
  Fly   745 TARSFDTVSIIRVPQGKEPRVFKRMFPNW 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	46/110 (42%)
		gelsolin_like	618..706	CDD:200436	21/92 (23%)
		gelsolin_S3_like	729..828	CDD:200448	28/99 (28%)
		gelsolin_like	920..1015	CDD:200436	24/119 (20%)
		gelsolin_S5_like	1037..1141	CDD:200444	29/111 (26%)
		gelsolin_S6_like	1151..1250	CDD:200447	34/105 (32%)
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	46/110 (42%)
		gelsolin_S2_like	191..283	CDD:200445	21/92 (23%)
		gelsolin_S3_like	307..404	CDD:200448	28/99 (28%)
		ADF_gelsolin	470..558	CDD:301701	21/90 (23%)
		ADF_gelsolin	569..661	CDD:301701	27/108 (25%)
		gelsolin_S6_like	675..774	CDD:200447	34/105 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850