DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and vill

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001005657.1	Gene:	vill / 448145	XenbaseID:	XB-GENE-945607	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	228/793 - (28%)
Similarity:	350/793 - (44%)	Gaps:	128/793 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 PGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAI 561
            |||.||.:|......|.|..:|.|:||||||:|..|....||:. :|.:|||.:::.|::..||.
Frog    12 PGLQIWSMEKMKLVPIPEKAYGSFFEGDCYILLYNKQTPNGLIS-DIHYWIGKDSSQDEQGSAAF 75

  Fly   562 HAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIE-EMIHITRLYLVHA 625
            :|..:...||......||.||.||..|.|.|:..|||.:|| .::||..:| .|.:|.|  |:|.
Frog    76 YATQIDGLLGGGPIQHREVQGHESATFKSYFKNGVIYKKGG-VSSGFKHVETNMYNIRR--LLHV 137

  Fly   626 YGAT-IHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCE 689
            .|.. :....||.:..|.:....|:||||..|..|.|..|..:...:|..:|:.|...||..:.:
Frog   138 KGKKHVTATEVAMSWNSFNKGDVFLLDLGKVIIQWNGPESNKSERIRACSLAQSIRDDERGGRAQ 202

  Fly   690 IQLERQGEESAEFWQ----GLGMTSEEADAAEPPKEHVP----EDYQPVQPRLYQVQLGMGYLE- 745
            |.:....::|.:..|    .||..:.|.      |:.||    ::.|....|||.|      .|
Frog   203 IGVIDNEQDSPDLMQIMVAVLGARTGEL------KDSVPDEKADEQQKANVRLYHV------FEK 255

  Fly   746 ---LPQVELPEQKLCHTLLNSKHVYILD-CYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPD 806
               |...||..:.|...||..:..:||| ....::||.||.|:...::||...:.........|.
Frog   256 DANLVVQELATKPLTQDLLQHEDCHILDQGGVKIYVWRGKNSSPEEKSAAFSRAVGFIQAKGYPP 320

  Fly   807 YALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPR 871
            ...|..|.:|.|..:|:..|..|.:|..........||.|.       |:.::|:.|:..|:
Frog   321 TTNVEVVNDGAESAMFKQLFQNWKDVGETQGLGKTFSVGKI-------AKVEQTKFDVNQLY--- 375

  Fly   872 QSAMPLAEAEQL--------EEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYC 928
              |.|...|||.        .|.|.  :|.:|...:|.:.:        |:||.|:||:.|..|
Frog   376 --ARPELAAEQRMVDDASGNVEVWR--IEKLELAEVEPRTY--------GQFYGGDCYLILYTY- 427

  Fly   929 IPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTF---TLQKKFK 990
                                .||...|.       ::|.|.||:|.........|   .|.||:.
Frog   428 --------------------MKSGRPNY-------LLYMWLGRHASQDEITACAFQAVQLDKKYH 465

  Fly   991 AMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRL 1055
                ::...:|:...:|.....:.||.|.||:.| ...:....:.::|::.|.::.. ....|:.
Frog   466 ----DQPVQIRVTMGKEPRHLQAMFKGKMIIYEG-GTSRLGVHEPEAPIKLFQVKGT-NEYNTKA 524

  Fly  1056 IQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACN----EEAKLVQDIAEQMFNSPW 1116
            .::...|..|||...::|    :||     .:.|:|.| |.|:    |.||.|.:|..:.
Frog   525 TEVPARASSLNSNDVFVL----KTE-----SMCYLWCG-KGCSGDEREMAKTVANIISKQ----- 574

  Fly  1117 VSLQILNEGDEPENFFWVALGGRKPYDTDAEY----MNYT-RLFRCSNERGYYTVAEKCADFCQD 1176
             ..|.:.||.||.. |||||||:.||.:|..:    :.|: |||.|||:.|.:.:.| ..||||.
Frog   575 -DKQTILEGQEPAE-FWVALGGKAPYASDKRFQEQAVQYSPRLFECSNQTGRFVMTE-VVDFCQS 636

  Fly  1177 DLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQ-HMRIKQPERPRKLFLTMKNKESR 1240
            ||.:||:|:||..|.:|||:|...::.|...:.|::|.|:: |...:....|  :.|..:..|..
Frog   637 DLDEDDVMLLDTWEEIFLWVGKSANDYEKTESVKASQEYLRAHPAGRDLATP--IILVKQGHEPP 699

  Fly  1241 RFTKCFHGWSAFK 1253
            .||..|:.|.:.|
Frog   700 TFTGWFNAWDSHK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	42/104 (40%)
		gelsolin_like	618..706	CDD:200436	24/92 (26%)
		gelsolin_S3_like	729..828	CDD:200448	28/103 (27%)
		gelsolin_like	920..1015	CDD:200436	18/97 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	32/107 (30%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/100 (36%)
vill	NP_001005657.1	gelsolin_S1_like	5..116	CDD:200446	42/104 (40%)
		gelsolin_S2_like	133..224	CDD:200445	24/92 (26%)
		gelsolin_S3_like	244..342	CDD:200448	28/103 (27%)
		gelsolin_S4_like	386..486	CDD:200449	27/141 (19%)
		gelsolin_S5_like	507..597	CDD:200444	32/107 (30%)
		gelsolin_S6_like	613..709	CDD:200447	35/98 (36%)
		VHP	842..876	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010