Protein Alignment fliI and scrib

DIOPT Version :10

• Sequence 1: NP_525097.1
• Gene: fliI / 33110
• FlyBaseID: FBgn0000709
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Alignment Length: 489
• Identity: 134/489 - (27%)
• Similarity: 213/489 - (43%)
• Gaps: 70/489 - (14%)

  Fly    22 PSSMRQMSR-VQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEKIFGELTELSCLRSLDLRHN 85
            |..:.:.|| ::.|.||...:.::|:....|.:|..|.|:.|.:.::..::.....|..||:..|
  Fly    29 PEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRN 93

  Fly    86 QLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLSNNQIESIPTPLFIHLTDLL 150
            .:.:  ||.::.||:.|...|.|.|.:.::|.|..:.|||.||.|::..:.::|.. |..||.|.
  Fly    94 DIPD--IPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPAD-FGSLTQLE 155

  Fly   151 FLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELF------------------QLRQLPS----L 193
            .|:|..|.|:.||....:|..||.|||..|.:|..                  ||::||.    |
  Fly   156 SLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLL 220

  Fly   194 QSLEVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELT 258
            ..|..|.:|  :..|...|..|..|.:|.:|||:.|.|..|||.:..:..|..|.|..|.|..|.
  Fly   221 TKLTYLDVS--ENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLN 283

  Fly   259 AGVELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANN 323
            ..:...:.::.|.|:.|.|..|||::.::.||..|.|:.|.|.:  :|..||:...|.|.|..:|
  Fly   284 DTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEY--LPLEIGQCANLGVLSLRDN 346

  Fly   324 LLEMVPEGLCRCGALKQLNLSCNRLITLP--------DAIHLLEGLDQLDLRNNPELVMPPKPSE 380
            .|:.:|..|..|..|..|::|.|:|:.||        .|:.|.|...|      |.|...|....
  Fly   347 KLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQ------PLLTFQPDTDA 405

  Fly   381 ASKATSLEFYNIDFSLQTQLRLAGAAVPPSMPSSATPKDSTARKIRLRRGPRSEGDQDAAKVLKG 445
            .:....|..|               .:|.......||    ||.:.....|..| .:.:..|:|.
  Fly   406 ETGEQVLSCY---------------LLPQQEYQPITP----ARDLESDSEPFEE-REPSRTVVKF 450

  Fly   446 MKDVAKDKD----NEAGAVPED--GKPESLKPKR 473
            .::..::|:    .:....|:|  .|.:.||.:|
  Fly   451 SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVER 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	1/7 (14%)
		leucine-rich repeat	31..53	CDD:275380	5/21 (24%)
		LRR	33..405	CDD:443914	115/401 (29%)
		leucine-rich repeat	54..76	CDD:275380	4/21 (19%)
		leucine-rich repeat	77..101	CDD:275380	8/23 (35%)
		leucine-rich repeat	102..124	CDD:275380	6/21 (29%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		leucine-rich repeat	149..171	CDD:275380	8/21 (38%)
		leucine-rich repeat	172..195	CDD:275380	12/44 (27%)
		leucine-rich repeat	196..220	CDD:275380	7/23 (30%)
		leucine-rich repeat	221..243	CDD:275380	9/21 (43%)
		leucine-rich repeat	244..266	CDD:275380	6/21 (29%)
		leucine-rich repeat	267..289	CDD:275380	7/21 (33%)
		leucine-rich repeat	290..314	CDD:275380	8/23 (35%)
		leucine-rich repeat	315..335	CDD:275380	7/19 (37%)
		leucine-rich repeat	338..360	CDD:275378	9/29 (31%)
		gelsolin_S1_like	491..602	CDD:200446
		gelsolin_like	618..706	CDD:200436
		gelsolin_S3_like	729..828	CDD:200448
		gelsolin_like	920..1015	CDD:200436
		gelsolin_S5_like	1037..1141	CDD:200444
		gelsolin_S6_like	1151..1250	CDD:200447
scrib	NP_001163746.1	leucine-rich repeat	18..38	CDD:275380	2/8 (25%)
		LRR_8	37..95	CDD:404697	14/57 (25%)
		leucine-rich repeat	39..61	CDD:275380	5/21 (24%)
		leucine-rich repeat	62..84	CDD:275380	4/21 (19%)
		LRR	67..408	CDD:443914	106/353 (30%)
		leucine-rich repeat	85..107	CDD:275380	8/23 (35%)
		leucine-rich repeat	108..130	CDD:275380	6/21 (29%)
		leucine-rich repeat	131..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..176	CDD:275380	8/21 (38%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		leucine-rich repeat	200..222	CDD:275380	5/21 (24%)
		leucine-rich repeat	223..245	CDD:275380	7/23 (30%)
		leucine-rich repeat	269..289	CDD:275380	6/19 (32%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	8/23 (35%)
		leucine-rich repeat	361..382	CDD:275380	7/20 (35%)
		PDZ1_Scribble-like	730..816	CDD:467188
		PDZ2_Scribble-like	927..1019	CDD:467187
		PDZ3_Scribble-like	1238..1327	CDD:467186
		PDZ4_Scribble-like	1331..1428	CDD:467185