DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and vil1

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_956532.1	Gene:	vil1 / 393207	ZFINID:	ZDB-GENE-040426-799	Length:	834	Species:	Danio rerio

Alignment Length:	811	Identity:	209/811 - (25%)
Similarity:	355/811 - (43%)	Gaps:	129/811 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 EKPQLDYSKFFEKDDGQLPGLTIWEIENF----LPNKIEEVVHGKFYEGDCYIVL---KTKFDDL 536
            ::.:.|..|...|   ..|||.||.:||.    .|:|    ..|:|:|||.|::|   ||..:
Zfish     3 QEVKTDVPKVLNK---TTPGLQIWRVENMELVPCPSK----TFGQFFEGDSYVILYTHKTSNN-- 58

  Fly   537 GLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEG 601
              ..::|.:|:|...:.|:...|||:...:.:.||......||.||.||..|...|:..:||.:|
Zfish    59 --FSYDIHYWLGKSTSQDEMGAAAIYTTQMDDHLGGVAVQHRETQGHESATFQGYFKQGIIYKKG 121

  Fly   602 G------RTATGFYTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWM 660
            |      :..|..|.|..::|:..  ..|.....:.:     :..|.:....|:||||:.|..|.
Zfish   122 GVASGMKQVETNTYNIRRLLHVKG--NKHVVAGEVEM-----SWNSFNKGDVFLLDLGSLIIQWN 179

  Fly   661 GERSKNTLNSKARLMAEKISKTERKNKCEIQ-LERQGEESAE-----FWQGLGMTSEEADAAEPP 719
            |.:|......:...:|:.|...||..:.::. :|...|:|:|     ..|.||...:....|.|
Zfish   180 GPKSNRMERLRGMNLAKDIRDRERGGRAQVAVVEGDDEQSSEEAMKLMKQSLGERPKNIKEAIP- 243

  Fly   720 KEHVPEDYQPVQPRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYILD-CYTDLFVWFGKKS 783
             :.:.::......:||.:....|.|.:.:|.:  :.|...||.::..|:|| ....:|:|.|||:
Zfish   244 -DEIVDEKLKTAIKLYHISDAQGSLVVQEVAV--KPLTQDLLKTEDCYLLDQGGIKIFIWKGKKA 305

  Fly   784 TRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGW---DEVMAVDFTRTAKSVA 845
            ::..|..::|::.........|....:..|.||.|..:|:..|..|   .:.:.:..|.....:|
Zfish   306 SKAERTESLKMAEAYVKAKGYPVSTYIETVSEGAESSVFKQLFQKWTDKGQTVGMGTTHNPGKIA 370

  Fly   846 KTGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEE 910
            |. ..:...|.....|.|:||    :|..:.....|  .|.|.          :|:.:...:..:
Zfish   371 KV-EQVKFDATSMHARPDIAA----QQKMVDDGSGE--AEVWR----------IEDNELAPVDRK 418

  Fly   911 ELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGN 975
            .||.||.|:||:.|.:|                   :||         .:...::|.||||:|..
Zfish   419 WLGHFYGGDCYLILYKY-------------------EVS---------SKFHYILYMWQGRHAST 455

  Fly   976 MGWLTFTF---TLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKS 1037
            .......:   .|.:|:.   ||.:: ||:...:|.:..|:.||.|.|::. :...:..:::.:.
Zfish   456 AELTACAYQAVILDQKYN---GEPVQ-VRVPMGKEPMHLMAIFKGKMIVYE-EGSSREGSSQSRP 515

  Fly  1038 PVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILHVPFETEDDSQSGIVYVWIGSKACN---- 1098
            .|..||:... ....||..::.|.:..|||...::|         |.....|:|.| |.|:
Zfish   516 SVRLFHVHGT-NEFNTRATEVPPRSSSLNSNDVFVL---------STDKCCYLWYG-KGCSGDER 569

  Fly  1099 EEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGRKPYDTDA----EYMNYT-RLFRCS 1158
            |.||.:.||..:.      ..|::.||.||.: |||.|||:..|.::.    |.::.| |||.||
Zfish   570 EMAKSLADIISER------EKQVIAEGQEPAD-FWVNLGGKSQYASNKRLQDENISITPRLFECS 627

  Fly  1159 NERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVEVKLAYKSAQVYIQ-HMRIK 1222
            |:.|.: :|.:..:|.||||.:||:|:||..:.|:||:|...::.|.:.|..:||.|:: |...:
Zfish   628 NQTGRF-IATEITNFNQDDLDEDDVMLLDIWDQVYLWIGKGANDTEKREAVVTAQEYLKSHPAGR 691

  Fly  1223 QPERPRKLFLTMKNKESRRFTKCFHGWSAFK 1253
            ..:.|  :.:..:..|...||..||.|...|
Zfish   692 DLDTP--VLVVKQGFEPPTFTGWFHAWDPQK 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	38/117 (32%)
		gelsolin_like	618..706	CDD:200436	20/93 (22%)
		gelsolin_S3_like	729..828	CDD:200448	25/99 (25%)
		gelsolin_like	920..1015	CDD:200436	20/97 (21%)
		gelsolin_S5_like	1037..1141	CDD:200444	32/107 (30%)
		gelsolin_S6_like	1151..1250	CDD:200447	35/100 (35%)
vil1	NP_956532.1	gelsolin_S1_like	18..122	CDD:200446	37/111 (33%)
		gelsolin_S2_like	139..225	CDD:200445	20/92 (22%)
		gelsolin_S3_like	252..350	CDD:200448	25/99 (25%)
		gelsolin_S4_like	394..494	CDD:200449	29/143 (20%)
		gelsolin_S5_like	515..605	CDD:200444	32/107 (30%)
		gelsolin_S6_like	621..717	CDD:200447	34/98 (35%)
		VHP	800..834	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820