DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Svil

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster

Alignment Length:	1379	Identity:	270/1379 - (19%)
Similarity:	477/1379 - (34%)	Gaps:	462/1379 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 IPP--------ELFHL--EELTTLDLSHNKLKEVPEGLERAKNLIVLNLSNNQIE-----SIPT- 140
            :||        :|.|:  ||.|:...:.:..||.|:..:         |...|.|     |.||
  Fly  3300 LPPLPLGGGFVKLRHVAKEEDTSSSSNTSSAKESPDKKD---------LRQEQAEASGDSSHPTA 3355

  Fly   141 -PLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSLEVLKMSG- 203
             |.|:.       .:..:..|.:.|..|.|:..||..::               :.|..|..||
  Fly  3356 LPQFLQ-------GVQRSSTEVMGPDQRSLVISKTGSIA---------------ERLAALHKSGE 3398

  Fly   204 -------TQRTLL------NFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLS----D 251
                   ::|..:      ||.....|||:    .||...||..|        |:..:|.    .
  Fly  3399 DDWKKRISKRDEVDDVHRENFVNESLSLAH----SLSDKPLPPSP--------LIPTSLEGGKVS 3451

  Fly   252 NELTELTAGVELW-QRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGAL 315
            :.|::|....|.| ||:|..:..:..:..         :|::...:..:|.||
  Fly  3452 DRLSKLKCNSENWKQRIEQTDAKKFTVAG---------RLQKKAQSPVELQFE------------ 3495

  Fly   316 EVFSAANNLLEMVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLR--NNPELVMPPKP 378
               .:||:..:..|                                 .|::|  |.|:|.:...|
  Fly  3496 ---RSANDAAKKCP---------------------------------MLEVRSANQPQLGLAKSP 3524

  Fly   379 S-EASKATSLEFYNIDFSLQTQLRLAGAAVPPSMPSSATPKDSTARKIRLRRGPRSEGDQDAAKV 442
            | ..:.:||     .:.:.::.||..........|:|.:..:|::.:        |:|::.:.:.
  Fly  3525 SMMVTSSTS-----TNSTSKSALRSLSVNPEEEGPTSLSRSNSSSSE--------SDGERKSPQN 3576

  Fly   443 LKGMKDVAKDKDNEAGAVPEDGKPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENF 507
            .|..|::|.:|...|             |......::.|:||..:.|               |||
  Fly  3577 AKQNKELANNKSAAA-------------PTNVGARIQVPRLDDKETF---------------ENF 3613

  Fly   508 L---PNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNF 569
            .   |.|.|.|.           :..:.|||:.          ..|..:.||     |....:..
  Fly  3614 FSSKPKKEENVQ-----------LEISAFDDIK----------PTERLVSKR-----HVQGPKGR 3652

  Fly   570 LGAR----CRTVREEQGDE-SEQFLSLFETEV--IYIEG-GRTA-------TGFYTIEEM----- 614
            ..||    ....||:...| :|....:.|.|:  :.:|. |..|       .|..::|:.
  Fly  3653 RAARNPLKSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLASVEDFKSVAL 3717

  Fly   615 ----IHITRLY-------LVHAYGATIHLEP--VAPAITSLDPRHAFVLDLGTHIYIWMGERSKN 666
                |.:.:::       |:|..|.| |::.  |.|..|||:....|:|..|:.::.::|..:..
  Fly  3718 RSSSIPLQQMWLPHKPVMLLHVKGRT-HVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANV 3781

  Fly   667 TLNSKARLMAEKISKTERKNK---C----EIQL-------ERQGEESAEFWQGLG-MTSEEADAA 716
            ...|:::    ||.....:||   |    |:.|       |||..   :|||.|| ...:::|.|
  Fly  3782 IEISRSK----KICAAIVENKDLGCTATQEVILTDGKYLKERQWR---QFWQLLGKKEDDQSDIA 3839

  Fly   717 EPPKEHVPED-------------YQPVQPRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYI 768
            |  ..|..||             |:.....|..::...|.  :|:|:         :|:::.|.:
  Fly  3840 E--CGHADEDDVFESSLIETNKIYEYQDEALIPLEKFWGC--IPKVD---------MLDTRKVLV 3891

  Fly   769 LDCYTDLFVWFGKKSTRLVRAAAVKLSRELF---NMMD--------------------------- 803
            .|..::|:||.||.:....:.||::|::|.|   |..|
  Fly  3892 FDFGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRC 3956

  Fly   804 --RPDYALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKS------VAKTGANLTQWARQQET 860
              ||::.::.::.:..|..:|:.||:.|.|:...|..:...|      .|..|..|.:....||.
  Fly  3957 AQRPEWCVLGKITQNMETVLFKEKFSDWPEIEREDLEKDYLSNGVHMVRALNGTALHKGEPYQEP 4021

  Fly   861 RTDLAALFMPRQSAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLP-----------EEELGR 914
            .             :.|.:|......:.||.:.|..|.:..|...:..           .::.|.
  Fly  4022 N-------------LVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGH 4073

  Fly   915 FYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNA-----G 974
            ||:.|.|:....|.|.:            ...::|...:|.......:||.:.|||:::     |
  Fly  4074 FYSAESYIVRWIYQISV------------TVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKG 4126

  Fly   975 NMGWLTFTFTLQKKFKAMFGEELEVVRIFQQQENLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPV 1039
            ....||.....:|      |.::   |:.|..|...|:..| |:...|.|:   |....:..|..
  Fly  4127 AAALLTVELDKEK------GAQM---RVSQGDECTAFVRLF-RQMWQHRGR---KEQCLERHSEW 4178

  Fly  1040 EFFHLRSNGGALTTRLIQINPDAVHLNS-TFCYILHVPFETEDDSQSGIVYVWIGSK-------- 1095
            ..:.|:.|... .|.:.::...:.||.| :...::|        ...|.|.||.|||
  Fly  4179 RLYQLQGNVSE-ETIIKEVVCQSSHLRSRSSMLLIH--------GSQGNVIVWHGSKSAPHTRNV 4234

  Fly  1096 ACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPE------------NFFWVALGGRKPYDTDAEY 1148
            |......|::.:.:.:|::...:|..:.||.:.:            |.:...|...|.:|..
  Fly  4235 AVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDYQ--- 4296

  Fly  1149 MNYTRLFRCSNERGYYTVAE-----KCAD------FCQDDL---ADDDIMILDNGEHVFLWMG-- 1197
               .|:|..|:.:|.:...|     :|.|      |.|..|   ....|.:||:|:.::||||
  Fly  4297 ---IRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMGWW 4358

  Fly  1198 PRCSEVEVKLAYKSA--------------------QVYIQHMRIKQPERPRKLFLTMKNK----- 1237
            | ..:|::....:|:                    :..:.:.|.|..|...:.|..:|.:
  Fly  4359 P-LEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRAKHGENENEPFHGIKGQVVWAG 4422

  Fly  1238 -ESRRFTKCFHGWS 1250
             |...|...|..|:
  Fly  4423 LEPLAFKALFPDWT 4436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566	7/29 (24%)
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064	51/247 (21%)
		leucine-rich repeat	77..101	CDD:275380	4/18 (22%)
		LRR_8	101..159	CDD:290566	13/64 (20%)
		leucine-rich repeat	102..124	CDD:275380	4/21 (19%)
		leucine-rich repeat	125..148	CDD:275380	8/29 (28%)
		leucine-rich repeat	149..171	CDD:275380	4/21 (19%)
		LRR_8	152..231	CDD:290566	18/92 (20%)
		leucine-rich repeat	172..195	CDD:275380	2/22 (9%)
		leucine-rich repeat	196..220	CDD:275380	9/37 (24%)
		leucine-rich repeat	221..243	CDD:275380	5/21 (24%)
		LRR_8	243..300	CDD:290566	10/61 (16%)
		leucine-rich repeat	244..266	CDD:275380	6/26 (23%)
		leucine-rich repeat	267..289	CDD:275380	1/21 (5%)
		leucine-rich repeat	290..314	CDD:275380	4/23 (17%)
		LRR_8	315..370	CDD:290566	6/56 (11%)
		leucine-rich repeat	315..335	CDD:275380	3/19 (16%)
		leucine-rich repeat	338..360	CDD:275378	0/21 (0%)
		gelsolin_S1_like	491..602	CDD:200446	23/121 (19%)
		gelsolin_like	618..706	CDD:200436	28/110 (25%)
		gelsolin_S3_like	729..828	CDD:200448	25/130 (19%)
		gelsolin_like	920..1015	CDD:200436	19/99 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	23/124 (19%)
		gelsolin_S6_like	1151..1250	CDD:200447	29/140 (21%)
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	25/99 (25%)
		gelsolin_like	3859..3965	CDD:200436	22/116 (19%)
		ADF_gelsolin	<4069..4158	CDD:301701	23/109 (21%)
		gelsolin_S5_like	4176..4279	CDD:200444	21/111 (19%)
		ADF_gelsolin	4328..4435	CDD:301701	22/107 (21%)
		VHP	4492..4526	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020