DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Svil

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_038951840.1	Gene:	Svil / 361256	RGDID:	1306354	Length:	2303	Species:	Rattus norvegicus

Alignment Length:	1317	Identity:	274/1317 - (20%)
Similarity:	477/1317 - (36%)	Gaps:	418/1317 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 SLEVLKMSGTQ--RTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVV---TLVRLNLSDNEL 254
            |||:...|.|.  ..|..|.|:..||..  .|||......:....|.||:   :|.....:.:|.
  Rat  1051 SLELGNSSATHLGDELKEFSTAKSSLQE--SLDLKDKQASEENADVENVMRKFSLKEFGETASEK 1113

  Fly   255 TELT---AGVEL-----WQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGK 311
            ||..   |.|.:     |::.||......:|...|.|:....:::             :|:|...
  Rat  1114 TETAARKASVPMATPGAWKQQESSEQLAEKLFKNPCAMFASGEVK-------------VPAGDSS 1165

  Fly   312 LGALEVFSAANNLLEMVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPP 376
            |.                              |.::.:::.:.:.||:...:.|.:|  .|:
  Rat  1166 LD------------------------------SPSKTMSIKERLALLKKSGEEDWKN--RLI--- 1195

  Fly   377 KPSEASKAT-SLEFYNIDFSLQTQLR----------------LAGAAVPPSMPSSATPKDSTARK 424
            :..|.|||| .|....::.||:.:..                :..:..||:||::.......:..
  Rat  1196 RKQEYSKATGGLHSPEVEQSLKKKEEGGFTDDNAISNLLWEPVFASTYPPAMPAAHKHLSFVSVN 1260

  Fly   425 IRLRRGPRSEGDQDAAKVL----------KGMKDVAKDKD--NEAGAVPEDG--KPESLKP---- 471
            .|:.....|:...:..|.|          || :..|.|..  ..||.:.:.|  .|.::.|
  Rat  1261 QRVTESRESQMTIEERKHLITVREEAWKTKG-RGAANDSTQFTVAGRMVKKGLASPTAITPISSP 1324

  Fly   472 ----KRWDESLEKPQLDYSKFFEKDDGQLPG-LTIWEIENF---LPNKI---------------- 512
                .|....:.||..|..   .:.|.||.. |.:..:|.|   |.||:
  Rat  1325 LCSKSRGTTPVSKPLEDIE---ARPDMQLESDLKLDRLETFLRRLNNKVAGMQETVLTVTGKSVK 1386

  Fly   513 ------EEVVHGKFYEGDCYIVLKT--KFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNF 569
                  ::....|||....:.:.::  :.::    |:::.|        |.      :|..|.:.
  Rat  1387 EVMKLDDDETFAKFYRSVDHSLPRSPVELEE----DFDVIF--------DP------YAPKLTSL 1433

  Fly   570 LGARCRTVREEQ-------------------GDESEQFLSLFETEVIYIEGGR------------ 603
            :....|:||.::                   .:.:||.|:     |.::|..|
  Rat  1434 VAEHKRSVRPKRRVQASKNPLKLLAARDDLLQEYTEQRLN-----VAFMESKRMKVEKMSSNSNF 1493

  Fly   604 ---TATGFYTIEEMIHIT-------------------RLYLVHAYGATIHLEP--VAPAITSLDP 644
               |..|..:.|....|:                   :|.|:...|.. |::.  |.|..:||:.
  Rat  1494 SEVTLAGLASRENFSSISLRSVNLMEQNSNNSALPYKKLMLLQIKGRR-HVQTRLVEPRASSLNS 1557

  Fly   645 RHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCE---IQLERQG-----EESAE 701
            ...|:|....:.::|:||.|.....:||..:|..| :|:|:..|.   :|...:|     ..:.:
  Rat  1558 GDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLI-QTKRELGCRATYVQTIEEGINTHTHAAKD 1621

  Fly   702 FWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYLELPQV-ELPEQKL--------- 756
            ||:.||..:....|.:|.::           .||:..:    :|...| .|.:.||
  Rat  1622 FWKLLGGQTSYQSAGDPKED-----------ELYETAI----IETNCVYRLTDDKLVPDDDYWGK 1671

  Fly   757 ---CHTLLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELF-----------NMMD---- 803
               | :||.||.|.:.|..::::||.||:.|...|..|.:|::.|:           |.:|
  Rat  1672 IPKC-SLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGEC 1735

  Fly   804 ----------RPDYALVMRVPEGNEMQIFRTKFAGWDEVMAVDFTRTAKSVAKTGANLTQWARQQ 858
                      |||:|:..||.|.||..:|:.||..|.|:.           ..|..|..:...|:
  Rat  1736 NPLIPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTELK-----------RPTEKNSGEVVHQK 1789

  Fly   859 E-TRTDLAALFMPRQSAMPLAEAEQLEEEWNY----------DLEMMEA--------FVLENKKF 904
            : .|.|:....:.|..|.|...|..:.:..|.          |...:|.        .:|| ..:
  Rat  1790 DYPRADVKPYDVTRMVATPQMTASTILDGVNVGRGYGLVEGDDRRQVEITTVSVDVWHILE-FDY 1853

  Fly   905 VRLPEEELGRFYTGECYVFLCRYCIPIEEPENGS-EDGANPAADVSKSSANNQPEDEIQCVVYFW 968
            .|||.:.:|:|:.|:.||...:|   :.....|| :.|.:|.....|.          :||.:||
  Rat  1854 SRLPRQSIGQFHEGDAYVVKWKY---MASTAVGSRQKGEHPVRVAGKE----------KCVYFFW 1905

  Fly   969 QGRNAGNMGWLTFTFTLQKK-FKAMFGEELE-----VVRIFQQQENLKFMSHFKRKFIIHTGKRK 1027
            |||::          |:.:| ..|:...||:     .|::.|.:|...|:..|:...::|:|:|:
  Rat  1906 QGRHS----------TVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRRE 1960

  Fly  1028 D---------KAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNS----TFCYILHVPFET 1079
            :         :.:..:|:.|:|            ..|:::   |.|.:|    |...:|::
  Rat  1961 EEEENVQSEWRLYCVRGEVPME------------GNLLEV---ACHCSSLRSRTSMVVLNI---- 2006

  Fly  1080 EDDSQSGIVYVWIGSKACNEEAKLVQDIAEQ----------MFNSPWVSLQILNEGDEPENFFWV 1134
                ...::|:|.|.||.....::.:..|.:          :.:|..|::...:||.||.. ||.
  Rat  2007 ----NKALIYLWHGCKAQGHTKEVGRTAANKIKEECPLEAGLHSSSNVTIHECDEGSEPLG-FWD 2066

  Fly  1135 ALG--GRKPYD---TDAEYMNYT-RLFRCSNERGYYTVAE-----------KCADFCQDDL---A 1179
            |||  .||.||   .|....|:. |||..|:..|.::..|           ....|.|:||   .
  Rat  2067 ALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFSATEFVYPARAPSAVSSMPFLQEDLYSAP 2131

  Fly  1180 DDDIMILDNGEHVFLWMGPRCSEVEV------------KLAYKSAQVYIQHMRIKQPERPRKLFL 1232
            ...:.::||...|:||.|...:|.::            |.|.::...|.:...:|:|  |.|.:|
  Rat  2132 QPALFLVDNHHEVYLWQGWWPTENKITGSARIRWASDRKSAMETVLQYCRGKNLKRP--PPKSYL 2194

  Fly  1233 TMKNKESRRFTKCFHGW 1249
            .....|...||..|..|
  Rat  2195 IHAGLEPLTFTNMFPSW 2211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064	28/121 (23%)
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566	13/37 (35%)
		leucine-rich repeat	172..195	CDD:275380	274/1317 (21%)
		leucine-rich repeat	196..220	CDD:275380	9/25 (36%)
		leucine-rich repeat	221..243	CDD:275380	6/24 (25%)
		LRR_8	243..300	CDD:290566	12/64 (19%)
		leucine-rich repeat	244..266	CDD:275380	7/29 (24%)
		leucine-rich repeat	267..289	CDD:275380	5/21 (24%)
		leucine-rich repeat	290..314	CDD:275380	3/23 (13%)
		LRR_8	315..370	CDD:290566	5/54 (9%)
		leucine-rich repeat	315..335	CDD:275380	0/19 (0%)
		leucine-rich repeat	338..360	CDD:275378	3/21 (14%)
		gelsolin_S1_like	491..602	CDD:200446	25/157 (16%)
		gelsolin_like	618..706	CDD:200436	25/116 (22%)
		gelsolin_S3_like	729..828	CDD:200448	37/136 (27%)
		gelsolin_like	920..1015	CDD:200436	24/101 (24%)
		gelsolin_S5_like	1037..1141	CDD:200444	26/119 (22%)
		gelsolin_S6_like	1151..1250	CDD:200447	30/126 (24%)
Svil	XP_038951840.1	gelsolin_S2_like	1531..1627	CDD:200445	25/97 (26%)
		gelsolin_like	1652..1752	CDD:200436	26/100 (26%)
		gelsolin_S4_like	1835..1948	CDD:200449	33/136 (24%)
		gelsolin_S5_like	1968..2073	CDD:200444	26/128 (20%)
		ADF_gelsolin	2090..2212	CDD:417759	30/124 (24%)
		VHP	2268..2303	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920