DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fliI and Capg

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001013104.1	Gene:	Capg / 297339	RGDID:	1311724	Length:	349	Species:	Rattus norvegicus

Alignment Length:	349	Identity:	106/349 - (30%)
Similarity:	160/349 - (45%)	Gaps:	31/349 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 QLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACA 559
            |.|||.||.:|...|..|....||.|:.||.|:||....::..    .:..|||.:::.|::...
  Rat    17 QDPGLHIWRVEKLKPVPIARENHGIFFSGDSYLVLHNGPEEAS----HLHLWIGQQSSRDEQGAC 77

  Fly   560 AIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGGRTATGFYTIEEMIH-------- 616
            |:.||:|...||.|....||.||:||:.|:|.|...:.|.|||        :|...|
  Rat    78 AVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPQGLKYREGG--------VESAFHKTTSGTTP 134

  Fly   617 --ITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKI 679
              |.:||.|.. ...|.....|.:..|.:....|:||||.:|:.|.|.:|.....:|||.:|..|
  Rat   135 AAIRKLYQVKG-KKNIRATERALSWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAI 198

  Fly   680 SKTERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQ-PRLYQVQLGMGY 743
            ..:||:.|.::::...|||.||..|.||  .:.|.....|:|.:..|....| ..||:|....|.
  Rat   199 RDSERQGKAQVEIITDGEEPAEMIQVLG--PKPALKEGNPEEDITADQTNAQAAALYKVSDATGQ 261

  Fly   744 LELPQVELPEQKLCHTLLNSKHVYILD---CYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRP 805
            :.|.:| .........||.....::||   | ..:::|.|:|:....|.||::::....:.|...
  Rat   262 MNLTKV-ADSSPFASELLIPDDCFVLDNGLC-GKIYIWKGRKANEKERQAALQVADGFISRMRYS 324

  Fly   806 DYALVMRVPEGNEMQIFRTKFAGW 829
            ....|..:|:|.|..||:..|..|
  Rat   325 PNTQVEILPQGRESPIFKQFFKDW 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	39/106 (37%)
		gelsolin_like	618..706	CDD:200436	29/87 (33%)
		gelsolin_S3_like	729..828	CDD:200448	26/102 (25%)
		gelsolin_like	920..1015	CDD:200436
		gelsolin_S5_like	1037..1141	CDD:200444
		gelsolin_S6_like	1151..1250	CDD:200447
Capg	NP_001013104.1	gelsolin_S1_like	17..120	CDD:200446	39/106 (37%)
		Gelsolin-like 1	28..107		27/82 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	138..147		3/9 (33%)
		gelsolin_S2_like	139..226	CDD:200445	29/87 (33%)
		Gelsolin-like 2	147..222		25/74 (34%)
		gelsolin_S3_like	247..347	CDD:200448	26/101 (26%)
		Gelsolin-like 3	264..342		19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820