DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fliI and Gsn

DIOPT Version :10

Sequence 1:NP_525097.1 Gene:fliI / 33110 FlyBaseID:FBgn0000709 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_001004080.1 Gene:Gsn / 296654 RGDID:1303089 Length:780 Species:Rattus norvegicus


Alignment Length:839 Identity:223/839 - (26%)
Similarity:352/839 - (41%) Gaps:151/839 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   459 AVPEDGKPESLKPK-RWDESLEKPQ---LDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGK 519
            |....|:.:...|: |..|:  :|.   :::.:|.:.  |:.|||.||.:|.|....:...::|.
  Rat    26 ATASRGRAQERAPQSRVSET--RPSTMVVEHPEFLKA--GKEPGLQIWRVEKFDLVPVPPNLYGD 86

  Fly   520 FYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDE 584
            |:.||.|::|||.....|.|.:::.:|:|||.:.|:...|||..|.|.::|..|....||.||.|
  Rat    87 FFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFE 151

  Fly   585 SEQFLSLFETEVIYIEGGRTATGF-YTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAF 648
            |..|...|::.:.|.:|| .|:|| :.:...:.:.||:.|.. ...:....|..:..|.:....|
  Rat   152 SSTFQGYFKSGLKYKKGG-VASGFKHVVPNEVVVQRLFQVKG-RRVVRATEVPVSWDSFNNGDCF 214

  Fly   649 VLDLGTHIYIWMGERSKNTLNSKARLMAEKISK----TERKNKCEIQLERQGEESAEFWQGLGMT 709
            :||||.:||.|.|..|    |...||.|.::||    .||..:.::.:..:|.|.....|.||  
  Rat   215 ILDLGNNIYQWCGSGS----NKFERLKATQVSKGIRDNERSGRAQVHVSEEGSEPEAMLQVLG-- 273

  Fly   710 SEEADAAEPPKEHVPEDYQPVQ---------PRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKH 765
                     ||..:|:..:...         .:||:|....|.:.:..| ..|.....:.|.|:.
  Rat   274 ---------PKPDLPQGTEDTAKEDAANRRLAKLYKVSNSGGSMSVSLV-ADENPFAQSALRSED 328

  Fly   766 VYILDCYTD--LFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAG 828
            .:|||...|  :|||.||::....|.||:|.:.:..:.|..|....|..:|||.|..:|:..|..
  Rat   329 CFILDHGRDGKIFVWKGKQANMDERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFKN 393

  Fly   829 WDEVMAVDFTRTAKSVAKTGANL----TQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNY 889
            |.:....|           |..|    :..|..:....|.|.|    .::..:|....::::...
  Rat   394 WRDPDQTD-----------GPGLSYLSSHIANVERVPFDAATL----HTSTAMAAQHGMDDDGTG 443

  Fly   890 DLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSAN 954
            ..::..   :|....|.:.....|:||.|:.|:.|..|       .:|...|.            
  Rat   444 QKQIWR---IEGSNKVLVDPATYGQFYGGDSYIILYNY-------RHGGRQGQ------------ 486

  Fly   955 NQPEDEIQCVVYFWQGRNA-----GNMGWLTFTFTLQKKFKAMFGEELEVV----RIFQQQENLK 1010
                     ::|.|||..:     .....||          |...|||...    |:.|.:|...
  Rat   487 ---------IIYNWQGAQSTQDEVAASAILT----------AQLDEELGGTPVQSRVVQGKEPAH 532

  Fly  1011 FMSHF--KRKFIIHTGKRKDKAHTAKGKSPVEFFHLR-SNGGALTTRLIQINPDAVHLNSTFCYI 1072
            .||.|  |...|...|..:|...|....:  ..|.:| |:.||  ||.:::.|.|..|||...::
  Rat   533 LMSLFGGKPMIIYKGGTSRDGGQTTPAST--RLFQVRASSSGA--TRAVEVMPKAGALNSNDAFV 593

  Fly  1073 LHVPFETEDDSQSGIVYVWIGSKACNEE----AKLVQDIAEQMFNSPWVSLQILNEGDEPENFFW 1133
            |..|         ...|:|:|:.|.:.|    .:|::.:..|       .:|: .||.||:. ||
  Rat   594 LKTP---------SAAYLWVGTGASDAEKTGALELLKVLRAQ-------HVQV-EEGSEPDG-FW 640

  Fly  1134 VALGGRKPYDTDAEYMNY------TRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHV 1192
            .||||:..|.|.....:.      .|||.|||..|.:.:.|...:..|:|||.||:|:||..:.|
  Rat   641 EALGGKTAYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLATDDVMLLDTWDQV 705

  Fly  1193 FLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNK--ESRRFTKCFHGW 1249
            |:|:|....|.|...|..||:.||:   .....|.|:..:|:..:  |...|...|.||
  Rat   706 FVWVGKDSQEEEKTEALTSAKRYIE---TDPANRDRRTPITVVRQGFEPPSFVGWFLGW 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fliINP_525097.1 leucine-rich repeat 7..30 CDD:275380
leucine-rich repeat 31..53 CDD:275380
LRR 33..405 CDD:443914
leucine-rich repeat 54..76 CDD:275380
leucine-rich repeat 77..101 CDD:275380
leucine-rich repeat 102..124 CDD:275380
leucine-rich repeat 125..148 CDD:275380
leucine-rich repeat 149..171 CDD:275380
leucine-rich repeat 172..195 CDD:275380
leucine-rich repeat 196..220 CDD:275380
leucine-rich repeat 221..243 CDD:275380
leucine-rich repeat 244..266 CDD:275380
leucine-rich repeat 267..289 CDD:275380
leucine-rich repeat 290..314 CDD:275380
leucine-rich repeat 315..335 CDD:275380
leucine-rich repeat 338..360 CDD:275378
gelsolin_S1_like 491..602 CDD:200446 39/110 (35%)
gelsolin_like 618..706 CDD:200436 26/91 (29%)
gelsolin_S3_like 729..828 CDD:200448 30/109 (28%)
gelsolin_like 920..1015 CDD:200436 20/103 (19%)
gelsolin_S5_like 1037..1141 CDD:200444 32/108 (30%)
gelsolin_S6_like 1151..1250 CDD:200447 36/107 (34%)
GsnNP_001004080.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..48 4/21 (19%)
Actin-severing. /evidence=ECO:0000255 51..174 43/125 (34%)
gelsolin_S1_like 57..169 CDD:200446 40/113 (35%)
Actin-actin interfilament contact point. /evidence=ECO:0000250 121..124 1/2 (50%)
gelsolin_S2_like 184..273 CDD:200445 26/93 (28%)
Gelsolin-like 2. /evidence=ECO:0000255 196..268 22/75 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..286 10/52 (19%)
gelsolin_S3_like 296..393 CDD:200448 30/97 (31%)
Gelsolin-like 3. /evidence=ECO:0000255 315..387 23/71 (32%)
Actin-binding, Ca-sensitive. /evidence=ECO:0000255 432..780 103/396 (26%)
gelsolin_S4_like 437..537 CDD:200449 26/140 (19%)
gelsolin_S5_like 559..647 CDD:200444 32/109 (29%)
gelsolin_S6_like 664..762 CDD:200447 36/101 (36%)
Blue background indicates that the domain is not in the aligned region.

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