DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and GSN

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_000168.1	Gene:	GSN / 2934	HGNCID:	4620	Length:	782	Species:	Homo sapiens

Alignment Length:	837	Identity:	224/837 - (26%)
Similarity:	352/837 - (42%)	Gaps:	150/837 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 NEAGA----VPEDGKPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEV 515
            ::|||    ||| .:|.|:            .:::.:|.:.  |:.|||.||.:|.|....:...
Human    35 SQAGAPQGRVPE-ARPNSM------------VVEHPEFLKA--GKEPGLQIWRVEKFDLVPVPTN 84

  Fly   516 VHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREE 580
            ::|.|:.||.|::|||.....|.|.:::.:|:|||.:.|:...|||..|.|.::|..|....||.
Human    85 LYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREV 149

  Fly   581 QGDESEQFLSLFETEVIYIEGGRTATGF-YTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDP 644
            ||.||..||..|::.:.|.:|| .|:|| :.:...:.:.||:.|.. ...:....|..:..|.:.
Human   150 QGFESATFLGYFKSGLKYKKGG-VASGFKHVVPNEVVVQRLFQVKG-RRVVRATEVPVSWESFNN 212

  Fly   645 RHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISK----TERKNKCEIQLERQGEESAEFWQG 705
            ...|:||||.:|:.|.|..|    |...||.|.::||    .||..:..:.:..:|.|.....|.
Human   213 GDCFILDLGNNIHQWCGSNS----NRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQV 273

  Fly   706 LGMTSEEADAAEPPKEHVPEDYQPVQ---------PRLYQVQLGMGYLELPQVELPEQKLCHTLL 761
            ||           ||..:|...:...         .:||:|..|.|.:.:..| ..|.......|
Human   274 LG-----------PKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLV-ADENPFAQGAL 326

  Fly   762 NSKHVYILDCYTD--LFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRT 824
            .|:..:|||...|  :|||.||::....|.||:|.:.:....||.|....|..:|||.|..:|:.
Human   327 KSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQ 391

  Fly   825 KFAGW---DEVMAVDFTRTAKSVAKTGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEE 886
            .|..|   |:...:..:..:..:|..          :....|.|.|    .::..:|....::::
Human   392 FFKNWRDPDQTDGLGLSYLSSHIANV----------ERVPFDAATL----HTSTAMAAQHGMDDD 442

  Fly   887 WNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKS 951
            .....::..   :|....|.:.....|:||.|:.|:.|..|       .:|...|.
Human   443 GTGQKQIWR---IEGSNKVPVDPATYGQFYGGDSYIILYNY-------RHGGRQGQ--------- 488

  Fly   952 SANNQPEDEIQCVVYFWQGRNA-----GNMGWLTFTFTLQKKFKAMFGEELEVV----RIFQQQE 1007
                        ::|.|||..:     .....||          |...|||...    |:.|.:|
Human   489 ------------IIYNWQGAQSTQDEVAASAILT----------AQLDEELGGTPVQSRVVQGKE 531

  Fly  1008 NLKFMSHF--KRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFC 1070
            ....||.|  |...|...|..::...||...:  ..|.:|:| .|..||.:::.|.|..|||...
Human   532 PAHLMSLFGGKPMIIYKGGTSREGGQTAPAST--RLFQVRAN-SAGATRAVEVLPKAGALNSNDA 593

  Fly  1071 YILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVA 1135
            ::|..|         ...|:|:|:.|...|....|::...:...|   :|:. ||.||:. ||.|
Human   594 FVLKTP---------SAAYLWVGTGASEAEKTGAQELLRVLRAQP---VQVA-EGSEPDG-FWEA 644

  Fly  1136 LGGRKPYDTDAEYMNY------TRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFL 1194
            |||:..|.|.....:.      .|||.|||:.|.:.:.|...:..|:|||.||:|:||..:.||:
Human   645 LGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFV 709

  Fly  1195 WMGPRCSEVEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNK--ESRRFTKCFHGW 1249
            |:|....|.|...|..||:.||:   .....|.|:..:|:..:  |...|...|.||
Human   710 WVGKDSQEEEKTEALTSAKRYIE---TDPANRDRRTPITVVKQGFEPPSFVGWFLGW 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	40/110 (36%)
		gelsolin_like	618..706	CDD:200436	25/91 (27%)
		gelsolin_S3_like	729..828	CDD:200448	32/109 (29%)
		gelsolin_like	920..1015	CDD:200436	20/103 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	31/103 (30%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/107 (34%)
GSN	NP_000168.1	Actin-severing. /evidence=ECO:0000255	53..176		44/125 (35%)
		gelsolin_S1_like	59..171	CDD:200446	41/113 (36%)
		Actin-actin interfilament contact point	123..126		1/2 (50%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	162..169		1/6 (17%)
		gelsolin_S2_like	186..275	CDD:200445	25/93 (27%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	188..196		3/8 (38%)
		Gelsolin-like 2	198..238		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..285		10/48 (21%)
		gelsolin_S3_like	295..395	CDD:200448	32/100 (32%)
		Gelsolin-like 3	314..356		13/42 (31%)
		Actin-binding, Ca-sensitive. /evidence=ECO:0000255	434..782		102/391 (26%)
		gelsolin_S4_like	439..539	CDD:200449	26/140 (19%)
		gelsolin_S5_like	561..649	CDD:200444	31/104 (30%)
		gelsolin_S6_like	666..764	CDD:200447	36/101 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820