DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Flii

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001008280.1	Gene:	Flii / 287375	RGDID:	1307590	Length:	1270	Species:	Rattus norvegicus

Alignment Length:	1286	Identity:	716/1286 - (55%)
Similarity:	930/1286 - (72%)	Gaps:	60/1286 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLPFVRGVDFTKNDF-SATFPSSMRQMSRVQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEK 66
            |||||||||.:.||| ...||.:::.|:.::||.|:||.|..:||||..||||||||::||.|..
  Rat     6 VLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTT 70

  Fly    67 IFGELTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLS 131
            :.|||:.|..||::..|.|.|||||:|.::|.|::|:.||||||:|.|.|..||.|||::|||||
  Rat    71 LHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLS 135

  Fly   132 NNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSL 196
            :|.|:|||..|||:|||||:||||.||||:||||.|||::|:||.|:.|||...||||||::.:|
  Rat   136 HNSIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMMAL 200

  Fly   197 EVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELTAGV 261
            :.|.:..||||..|.|||::.|:||.::|||.|.|.::|:|:|.:..|.|||||.|::.||:..:
  Rat   201 QTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPNLHRLNLSSNQIAELSLCI 265

  Fly   262 ELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLE 326
            :.|..||:||||||||.:||:|:|||.||::|.:|.|||:|:|:|||||||.:||.|.||||.||
  Rat   266 DQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAANNNLE 330

  Fly   327 MVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYN 391
            ::||.||||..|::|.|:.|||:|||:|||.|..::.||:|.||.|||||||::    .:.|:||
  Rat   331 LIPESLCRCPKLRKLVLNKNRLVTLPEAIHFLTEIEVLDVRENPSLVMPPKPAD----HTAEWYN 391

  Fly   392 IDFSLQTQLRLAGAAVPPSMPSSAT----PKDSTARKIRLRRGPRSEGDQDAAKVLKGMKDVAKD 452
            ||||||.|||||||: |.::.::|.    .||..|||:||||...|..|..|.:|||||.|||::
  Rat   392 IDFSLQNQLRLAGAS-PATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQE 455

  Fly   453 KDNEAGAVPEDGKPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVH 517
            | |:......|.:....|.:|||:.||||:||||:||.:|.|||||||||:||||:|..:||..|
  Rat   456 K-NKNQEESTDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFH 519

  Fly   518 GKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQG 582
            |||||.||||||||..||.|.|:|||::|||.||||||:||:|||||||||:|||.|||.|||.|
  Rat   520 GKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTAREEMG 584

  Fly   583 DESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLVHAYG-ATIHLEPVAPAITSLDPRH 646
            ||||.||.:|:.::.||||| ||:||||:|:..::||:|.|  || ..|.||||....||||||.
  Rat   585 DESEGFLQVFDNDISYIEGG-TASGFYTVEDTHYVTRMYRV--YGKKNIKLEPVPLKGTSLDPRF 646

  Fly   647 AFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSE 711
            .|:||.|..||:|.|.::..:..:||||.|||::|.|||.|.||.|..||:|..|||..||
  Rat   647 VFLLDQGLDIYVWRGAQATLSNTTKARLFAEKMNKNERKGKAEITLLVQGQEPPEFWDVLG---- 707

  Fly   712 EADAAEPP--KEHVPEDYQPVQPRLYQVQLGMGYLELPQVE---------------LPEQKLCHT 759
                .||.  |:|||:|:.|.||:||:|.||:|||||||:.               :|..:|..:
  Rat   708 ----GEPSEIKKHVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQS 768

  Fly   760 LLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRT 824
            ||:::.||||||::|:|:|.|:||.|||||||:||.:||..|:.||.:.:|.|..||.|.|:|:.
  Rat   769 LLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKA 833

  Fly   825 KFAGWDEVMAVDFTRTAKSVAK----TGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEE 885
            ||..||:|:.||:||.|::|.:    :|.......::.:.:.||.|||:|||..|||||||||.|
  Rat   834 KFKNWDDVLTVDYTRNAEAVLQGPGISGKVKRDTEKKDQMKADLTALFLPRQPPMPLAEAEQLME 898

  Fly   886 EWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIE-EPENGSEDGANPAA--- 946
            |||.||:.||.||||.:||.||.|||.|.|||.:||||||||.:|:| |.|...||....|:
  Rat   899 EWNEDLDGMEGFVLEGRKFTRLAEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKPEDKEGKASAEG 963

  Fly   947 ----DVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVRIFQQQE 1007
                :.:..:...|||::.||:|||||||.|.|||||||||:|||||:::|..:|||||:.||||
  Rat   964 REEEEAAAETEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQE 1028

  Fly  1008 NLKFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYI 1072
            |.||:||||||||||.||||    ..:...|. .:.:|:||.||.||.||||.|:..|||.||:|
  Rat  1029 NPKFLSHFKRKFIIHRGKRK----VTQTLQPT-LYQIRTNGSALCTRCIQINTDSSLLNSEFCFI 1088

  Fly  1073 LHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALG 1137
            |.||||:||:  .||||.|:|..:..:||||.:||...||: |..|.|::|||:||||||||.:|
  Rat  1089 LKVPFESEDN--QGIVYAWVGRASDPDEAKLAEDILNTMFD-PSYSKQVINEGEEPENFFWVGIG 1150

  Fly  1138 GRKPYDTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSE 1202
            .:||||.|||||.:|||||||||:||:.|.|||:|||||||||||||:||||:.|::|:|.:.|:
  Rat  1151 AQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQ 1215

  Fly  1203 VEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNKESRRFTKCFHGWSAFK 1253
            ||:||:.|:.||||||.|.|:.||||:|.|..|..|.|.||:|||.||.|:
  Rat  1216 VEIKLSLKACQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAWSTFR 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	11/23 (48%)
		leucine-rich repeat	31..53	CDD:275380	11/21 (52%)
		LRR_8	53..112	CDD:290566	32/58 (55%)
		leucine-rich repeat	54..76	CDD:275380	12/21 (57%)
		LRR_RI	70..304	CDD:238064	131/233 (56%)
		leucine-rich repeat	77..101	CDD:275380	12/23 (52%)
		LRR_8	101..159	CDD:290566	38/57 (67%)
		leucine-rich repeat	102..124	CDD:275380	13/21 (62%)
		leucine-rich repeat	125..148	CDD:275380	14/22 (64%)
		leucine-rich repeat	149..171	CDD:275380	17/21 (81%)
		LRR_8	152..231	CDD:290566	45/78 (58%)
		leucine-rich repeat	172..195	CDD:275380	13/22 (59%)
		leucine-rich repeat	196..220	CDD:275380	11/23 (48%)
		leucine-rich repeat	221..243	CDD:275380	9/21 (43%)
		LRR_8	243..300	CDD:290566	31/56 (55%)
		leucine-rich repeat	244..266	CDD:275380	10/21 (48%)
		leucine-rich repeat	267..289	CDD:275380	16/21 (76%)
		leucine-rich repeat	290..314	CDD:275380	15/23 (65%)
		LRR_8	315..370	CDD:290566	31/54 (57%)
		leucine-rich repeat	315..335	CDD:275380	13/19 (68%)
		leucine-rich repeat	338..360	CDD:275378	13/21 (62%)
		gelsolin_S1_like	491..602	CDD:200446	78/110 (71%)
		gelsolin_like	618..706	CDD:200436	46/88 (52%)
		gelsolin_S3_like	729..828	CDD:200448	54/113 (48%)
		gelsolin_like	920..1015	CDD:200436	56/102 (55%)
		gelsolin_S5_like	1037..1141	CDD:200444	55/103 (53%)
		gelsolin_S6_like	1151..1250	CDD:200447	63/98 (64%)
Flii	NP_001008280.1	LRR_RI	<2..139	CDD:238064	73/132 (55%)
		leucine-rich repeat	10..34	CDD:275380	11/23 (48%)
		LRR_8	33..91	CDD:290566	29/57 (51%)
		leucine-rich repeat	35..57	CDD:275380	11/21 (52%)
		leucine-rich repeat	58..80	CDD:275380	12/21 (57%)
		leucine-rich repeat	83..105	CDD:275380	10/21 (48%)
		LRR_RI	89..375	CDD:238064	165/285 (58%)
		leucine-rich repeat	106..128	CDD:275380	13/21 (62%)
		leucine-rich repeat	129..152	CDD:275380	14/22 (64%)
		LRR_8	131..186	CDD:290566	38/54 (70%)
		leucine-rich repeat	153..175	CDD:275380	17/21 (81%)
		leucine-rich repeat	176..199	CDD:275380	13/22 (59%)
		leucine-rich repeat	200..224	CDD:275380	11/23 (48%)
		LRR_8	223..281	CDD:290566	28/57 (49%)
		leucine-rich repeat	225..247	CDD:275380	9/21 (43%)
		leucine-rich repeat	248..270	CDD:275380	10/21 (48%)
		LRR_8	270..352	CDD:290566	51/81 (63%)
		leucine-rich repeat	271..318	CDD:275380	32/46 (70%)
		leucine-rich repeat	319..341	CDD:275380	15/21 (71%)
		gelsolin_S1_like	492..604	CDD:200446	78/111 (70%)
		gelsolin_like	619..703	CDD:200436	44/85 (52%)
		gelsolin_S3_like	723..837	CDD:200448	54/113 (48%)
		gelsolin_like	<976..1036	CDD:200436	41/59 (69%)
		gelsolin_S5_like	1054..1153	CDD:200444	55/102 (54%)
		gelsolin_S6_like	1164..1263	CDD:200447	63/98 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338117
Domainoid	1	1.000	391	1.000	Domainoid score	I754
eggNOG	1	0.900	-	-		E2759_KOG0444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11092
Inparanoid	1	1.050	1396	1.000	Inparanoid score	I112
OMA	1	1.010	-	-		QHG52569
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0007001
OrthoInspector	1	1.000	-	-		oto97859
orthoMCL	1	0.900	-	-		OOG6_106545
Panther	1	1.100	-	-	LDO	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5098
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770