DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and FLII

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_005256612.1	Gene:	FLII / 2314	HGNCID:	3750	Length:	1296	Species:	Homo sapiens

Alignment Length:	1310	Identity:	722/1310 - (55%)
Similarity:	935/1310 - (71%)	Gaps:	84/1310 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLPFVRGVDFTKNDF-SATFPSSMRQMSRVQWLTLDRTQLAEIPEELGHLQKLEHLSLNHNRLEK 66
            |||||||||.:.||| ...||.:::.|:.::||.|:||.|..:||||..||||||||::||.|..
Human     6 VLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTT 70

  Fly    67 IFGELTELSCLRSLDLRHNQLKNSGIPPELFHLEELTTLDLSHNKLKEVPEGLERAKNLIVLNLS 131
            :.|||:.|..||::..|.|.|||||:|.::|.|::|:.||||||:|.|.|..||.|||::|||||
Human    71 LHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLS 135

  Fly   132 NNQIESIPTPLFIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSHNPLELFQLRQLPSLQSL 196
            :|.|::||..|||:|||||:||||.||||:||||.|||::|:||.|:.|||...||||||::.:|
Human   136 HNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTAL 200

  Fly   197 EVLKMSGTQRTLLNFPTSIDSLANLCELDLSHNSLPKLPDCVYNVVTLVRLNLSDNELTELTAGV 261
            :.|.:..||||..|.|||::.|:||.::|||.|.|.::|:|:|.:.:|.|||||.|::|||:..:
Human   201 QTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCI 265

  Fly   262 ELWQRLESLNLSRNQLVALPAALCKLPKLRRLLVNDNKLNFEGIPSGIGKLGALEVFSAANNLLE 326
            :.|..:|:||||||||.:||:|:|||.||::|.:|.|||:|:|:|||||||..||.|.||||.||
Human   266 DQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLE 330

  Fly   327 MVPEGLCRCGALKQLNLSCNRLITLPDAIHLLEGLDQLDLRNNPELVMPPKPSEASKATSLEFYN 391
            :|||.||||..|::|.|:.|.|:|||:|||.|..::.||:|.||.|||||||::    .:.|:||
Human   331 LVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD----RAAEWYN 391

  Fly   392 IDFSLQTQLRLAGAAVPPSMPSSAT----PKDSTARKIRLRRGPRSEGDQDAAKVLKGMKDVAKD 452
            ||||||.|||||||: |.::.::|.    |||..|||:||||...|..|..|.:|||||.|||::
Human   392 IDFSLQNQLRLAGAS-PATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQE 455

  Fly   453 KDNEAGAVPEDGKPESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVH 517
            | |:......|.:..|.|.:|||:.||||:||||:||.:|.|||||||||:||||:|..:||..|
Human   456 K-NKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFH 519

  Fly   518 GKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQG 582
            |||||.||||||||..||.|.|:|||::|||.||||||:||:|||||||||:|||.|||||||.|
Human   520 GKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMG 584

  Fly   583 DESEQFLSLFETEVIYIEGGRTATGFYTIEEMIHITRLYLVHAYG-ATIHLEPVAPAITSLDPRH 646
            ||||:||.:|:.::.||||| ||:||||:|:..::||:|.|  || ..|.||||....||||||.
Human   585 DESEEFLQVFDNDISYIEGG-TASGFYTVEDTHYVTRMYRV--YGKKNIKLEPVPLKGTSLDPRF 646

  Fly   647 AFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKTERKNKCEIQLERQGEESAEFWQGLGMTSE 711
            .|:||.|..||:|.|.::..:..:||||.||||:|.|||.|.||.|..||:|..|||:.||
Human   647 VFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALG---- 707

  Fly   712 EADAAEPP--KEHVPEDYQPVQPRLYQVQLGMGYLELPQVE---------------LPEQKLCHT 759
                .||.  |:|||||:.|.||:||:|.||:|||||||:.               :|..:|..:
Human   708 ----GEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQS 768

  Fly   760 LLNSKHVYILDCYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRT 824
            ||:::.||||||::|:|:|.|:||.|||||||:||.:||..|:.||.:|.|.|..||.|.|:|:.
Human   769 LLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKA 833

  Fly   825 KFAGWDEVMAVDFTRTAKSVAK----TGANLTQWARQQETRTDLAALFMPRQSAMPLAEAEQLEE 885
            ||..||:|:.||:||.|::|.:    :|.......::.:.:.||.|||:|||..|.|||||||.|
Human   834 KFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLME 898

  Fly   886 EWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIE-EPENGSEDGANPA---- 945
            |||.||:.||.||||.|||.||||||.|.|||.:||||||||.:|:| |.|...||....|
Human   899 EWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKE 963

  Fly   946 -ADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVRIFQQQENL 1009
             .:.:..:...|||::.||:|||||||.|.|||||||||:|||||:::|..:|||||:.|||||.
Human   964 GEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENP 1028

  Fly  1010 KFMSHFKRKFIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLNSTFCYILH 1074
            ||:||||||||||.||||    ..:|......:.:|:||.||.||.||||.|:..|||.||:||.
Human  1029 KFLSHFKRKFIIHRGKRK----AVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILK 1089

  Fly  1075 VPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGR 1139
            ||||:||:  .||||.|:|..:..:||||.:||...||::.: |.|::|||:||||||||.:|.:
Human  1090 VPFESEDN--QGIVYAWVGRASDPDEAKLAEDILNTMFDTSY-SKQVINEGEEPENFFWVGIGAQ 1151

  Fly  1140 KPYDTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPRCSEVE 1204
            ||||.|||||.:|||||||||:||:.|.|||:|||||||||||||:||||:.|::|:|.:.|:||
Human  1152 KPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVE 1216

  Fly  1205 VKLAYKS---------------------------AQVYIQHMRIKQPERPRKLFLTMKNKESRRF 1242
            :||:.|:                           .||||||||.|:.||||:|.|..|..|...|
Human  1217 IKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQHMRSKEHERPRRLRLVRKGNEQHAF 1281

  Fly  1243 TKCFHGWSAF 1252
            |:|||.||||
Human  1282 TRCFHAWSAF 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	11/23 (48%)
		leucine-rich repeat	31..53	CDD:275380	11/21 (52%)
		LRR_8	53..112	CDD:290566	32/58 (55%)
		leucine-rich repeat	54..76	CDD:275380	12/21 (57%)
		LRR_RI	70..304	CDD:238064	130/233 (56%)
		leucine-rich repeat	77..101	CDD:275380	12/23 (52%)
		LRR_8	101..159	CDD:290566	37/57 (65%)
		leucine-rich repeat	102..124	CDD:275380	13/21 (62%)
		leucine-rich repeat	125..148	CDD:275380	13/22 (59%)
		leucine-rich repeat	149..171	CDD:275380	17/21 (81%)
		LRR_8	152..231	CDD:290566	45/78 (58%)
		leucine-rich repeat	172..195	CDD:275380	13/22 (59%)
		leucine-rich repeat	196..220	CDD:275380	11/23 (48%)
		leucine-rich repeat	221..243	CDD:275380	9/21 (43%)
		LRR_8	243..300	CDD:290566	31/56 (55%)
		leucine-rich repeat	244..266	CDD:275380	11/21 (52%)
		leucine-rich repeat	267..289	CDD:275380	15/21 (71%)
		leucine-rich repeat	290..314	CDD:275380	15/23 (65%)
		LRR_8	315..370	CDD:290566	31/54 (57%)
		leucine-rich repeat	315..335	CDD:275380	14/19 (74%)
		leucine-rich repeat	338..360	CDD:275378	12/21 (57%)
		gelsolin_S1_like	491..602	CDD:200446	79/110 (72%)
		gelsolin_like	618..706	CDD:200436	47/88 (53%)
		gelsolin_S3_like	729..828	CDD:200448	55/113 (49%)
		gelsolin_like	920..1015	CDD:200436	56/100 (56%)
		gelsolin_S5_like	1037..1141	CDD:200444	53/103 (51%)
		gelsolin_S6_like	1151..1250	CDD:200447	63/125 (50%)
FLII	XP_005256612.1	LRR_RI	<2..139	CDD:238064	73/132 (55%)
		leucine-rich repeat	10..34	CDD:275380	11/23 (48%)
		LRR_8	33..91	CDD:290566	29/57 (51%)
		leucine-rich repeat	35..57	CDD:275380	11/21 (52%)
		leucine-rich repeat	58..80	CDD:275380	12/21 (57%)
		leucine-rich repeat	83..105	CDD:275378	10/21 (48%)
		LRR_RI	89..374	CDD:238064	163/284 (57%)
		leucine-rich repeat	106..128	CDD:275380	13/21 (62%)
		leucine-rich repeat	129..152	CDD:275380	13/22 (59%)
		LRR_8	131..186	CDD:290566	37/54 (69%)
		leucine-rich repeat	153..175	CDD:275380	17/21 (81%)
		leucine-rich repeat	176..199	CDD:275380	13/22 (59%)
		leucine-rich repeat	200..224	CDD:275380	11/23 (48%)
		LRR_8	223..281	CDD:290566	28/57 (49%)
		leucine-rich repeat	225..247	CDD:275380	9/21 (43%)
		leucine-rich repeat	248..270	CDD:275380	11/21 (52%)
		leucine-rich repeat	271..293	CDD:275380	15/21 (71%)
		leucine-rich repeat	294..318	CDD:275380	15/23 (65%)
		leucine-rich repeat	319..339	CDD:275380	14/19 (74%)
		leucine-rich repeat	342..355	CDD:275378	5/12 (42%)
		gelsolin_S1_like	492..604	CDD:200446	79/111 (71%)
		gelsolin_like	619..706	CDD:200436	47/88 (53%)
		gelsolin_S3_like	723..837	CDD:200448	55/113 (49%)
		gelsolin_like	<974..1034	CDD:200436	41/59 (69%)
		gelsolin_S5_like	1053..1152	CDD:200444	53/101 (52%)
		gelsolin_S6_like	1163..1289	CDD:200447	63/125 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144407
Domainoid	1	1.000	396	1.000	Domainoid score	I755
eggNOG	1	0.900	-	-		E2759_KOG0444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11092
Inparanoid	1	1.050	1408	1.000	Inparanoid score	I119
Isobase	1	0.950	-	0	Normalized mean entropy	S2261
OMA	1	1.010	-	-		QHG52569
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0007001
OrthoInspector	1	1.000	-	-		oto90756
orthoMCL	1	0.900	-	-		OOG6_106545
Panther	1	1.100	-	-	LDO	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2528
SonicParanoid	1	1.000	-	-		X5098
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750