DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fliI and Gsn

DIOPT Version :9

Sequence 1:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_006498053.1	Gene:	Gsn / 227753	MGIID:	95851	Length:	802	Species:	Mus musculus

Alignment Length:	897	Identity:	239/897 - (26%)
Similarity:	371/897 - (41%)	Gaps:	173/897 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 LRLAGAAVPPSMPSSATPKDSTARKIRLRRGPRSEGDQDAAKVLKGMKDVAKDKDNEAGAVPEDG 464
            |.||..|:.||  .:||    |:|.....|.|:|.              |::.:.:..|  |...
Mouse    13 LLLALCALSPS--HAAT----TSRGRAQERAPQSR--------------VSEARVSARG--PRGS 55

  Fly   465 K-------PESLKPKRWDESLEKPQLDYSKFFEKDDGQLPGLTIWEIENFLPNKIEEVVHGKFYE 522
            .       |.||:|...       .:::.:|.:.  |:.|||.||.:|.|....:...::|.|:.
Mouse    56 PSNCLLFCPVSLQPSTM-------VVEHPEFLKA--GKEPGLQIWRVEKFDLVPVPPNLYGDFFT 111

  Fly   523 GDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRACAAIHAVNLRNFLGARCRTVREEQGDESEQ 587
            ||.|::|||.....|.|.:::.:|:|||.:.|:...|||..|.|.::|..|....||.||.||..
Mouse   112 GDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESST 176

  Fly   588 FLSLFETEVIYIEGGRTATGF-YTIEEMIHITRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLD 651
            |...|::.:.|.:|| .|:|| :.:...:.:.||:.|.. ...:....|..:..|.:....|:||
Mouse   177 FSGYFKSGLKYKKGG-VASGFKHVVPNEVVVQRLFQVKG-RRVVRATEVPVSWDSFNNGDCFILD 239

  Fly   652 LGTHIYIWMGERSKNTLNSKARLMAEKISK----TERKNKCEIQLERQGEESAEFWQGLGMTSEE 712
            ||.:||.|.|..|    |...||.|.::||    .||..:.::.:..:|.|.....|.||
Mouse   240 LGNNIYQWCGSGS----NKFERLKATQVSKGIRDNERSGRAQVHVSEEGGEPEAMLQVLG----- 295

  Fly   713 ADAAEPPKEHVPEDYQPVQ---------PRLYQVQLGMGYLELPQVELPEQKLCHTLLNSKHVYI 768
                  ||..:||..:...         .:||:|..|.|.:.:..| ..|.......|.|:..:|
Mouse   296 ------PKPALPEGTEDTAKEDAANRRLAKLYKVSNGAGSMSVSLV-ADENPFAQGALRSEDCFI 353

  Fly   769 LDCYTD--LFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALVMRVPEGNEMQIFRTKFAGWDE 831
            ||...|  :|||.||::....|.||:|.:.:..:.|..|....|..:|||.|..:|:..|..|.:
Mouse   354 LDHGRDGKIFVWKGKQANMEERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFKNWRD 418

  Fly   832 VMAVDFTRTAKSVAKTGANL----TQWARQQETRTDLAALFMPRQSAMPLAEAEQLEEEWNYDLE 892
            ....|           |..|    :..|..:....|.|.|    .::..:|....::::.....:
Mouse   419 PDQTD-----------GPGLGYLSSHIANVERVPFDAATL----HTSTAMAAQHGMDDDGTGQKQ 468

  Fly   893 MMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENGSEDGANPAADVSKSSANNQP 957
            :..   :|....|.:.....|:||.|:.|:.|..|       .:|...|.
Mouse   469 IWR---IEGSNKVPVDPATYGQFYGGDSYIILYNY-------RHGGRQGQ--------------- 508

  Fly   958 EDEIQCVVYFWQGRNA-----GNMGWLTFTFTLQKKFKAMFGEELEVV----RIFQQQENLKFMS 1013
                  ::|.|||..:     .....||          |...|||...    |:.|.:|....||
Mouse   509 ------IIYNWQGAQSTQDEVAASAILT----------AQLDEELGGTPVQSRVVQGKEPAHLMS 557

  Fly  1014 HF--KRKFIIHTGKRKDKAHTAKGKSPVEFFHLR-SNGGALTTRLIQINPDAVHLNSTFCYILHV 1075
            .|  |...|...|..:|...||  .:.:..|.:| |:.||  ||.:::.|.:..|||...::|..
Mouse   558 LFGGKPMIIYKGGTSRDGGQTA--PASIRLFQVRASSSGA--TRAVEVMPKSGALNSNDAFVLKT 618

  Fly  1076 PFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENFFWVALGGRK 1140
            |         ...|:|:|:.|...|....|::. ::..|..|.::   ||.||: .||.||||:.
Mouse   619 P---------SAAYLWVGAGASEAEKTGAQELL-KVLRSQHVQVE---EGSEPD-AFWEALGGKT 669

  Fly  1141 PYDTDAEYMNY------TRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGEHVFLWMGPR 1199
            .|.|.....:.      .|||.|||..|.:.:.|...:..|:|||.||:|:||..:.||:|:|..
Mouse   670 AYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKD 734

  Fly  1200 CSEVEVKLAYKSAQVYIQHMRIKQPERPRKLFLTMKNK--ESRRFTKCFHGW 1249
            ..|.|...|..||:.||:   .....|.|:..:|:..:  |...|...|.||
Mouse   735 SQEEEKTEALTSAKRYIE---TDPANRDRRTPITVVRQGFEPPSFVGWFLGW 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR_8	53..112	CDD:290566
		leucine-rich repeat	54..76	CDD:275380
		LRR_RI	70..304	CDD:238064
		leucine-rich repeat	77..101	CDD:275380
		LRR_8	101..159	CDD:290566
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		LRR_8	152..231	CDD:290566
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		LRR_8	243..300	CDD:290566
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		LRR_8	315..370	CDD:290566
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	39/110 (35%)
		gelsolin_like	618..706	CDD:200436	26/91 (29%)
		gelsolin_S3_like	729..828	CDD:200448	31/109 (28%)
		gelsolin_like	920..1015	CDD:200436	20/103 (19%)
		gelsolin_S5_like	1037..1141	CDD:200444	31/104 (30%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/107 (34%)
Gsn	XP_006498053.1	gelsolin_S1_like	79..191	CDD:200446	40/113 (35%)
		gelsolin_S2_like	206..295	CDD:200445	26/93 (28%)
		gelsolin_S3_like	318..415	CDD:200448	31/97 (32%)
		gelsolin_S4_like	459..559	CDD:200449	26/140 (19%)
		gelsolin_S5_like	581..669	CDD:200444	31/103 (30%)
		gelsolin_S6_like	686..784	CDD:200447	36/101 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820